A
Alun Thomas
Researcher at University of Utah
Publications - 139
Citations - 10540
Alun Thomas is an academic researcher from University of Utah. The author has contributed to research in topics: Population & Gene. The author has an hindex of 32, co-authored 136 publications receiving 10091 citations. Previous affiliations of Alun Thomas include University of Cambridge & University of Bath.
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Journal ArticleDOI
A draft sequence of the rice genome (Oryza sativa L. ssp indica)
Stephen A. Goff,Darrell O. Ricke,Tien-Hung Lan,Gernot G. Presting,Ronglin Wang,Molly Dunn,Jane Glazebrook,Allen Sessions,Paul Oeller,Hemant Varma,David Hadley,Don Hutchison,Christopher M. Martin,Fumiaki Katagiri,B. Markus Lange,Todd Moughamer,Yu Xia,Paul Budworth,Jingping Zhong,Trini Miguel,Uta Paszkowski,Shiping Zhang,Michelle Colbert,Wei-lin Sun,Lili Chen,Bret Cooper,Sylvia Park,Todd Charles Wood,Long Mao,Peter H. Quail,Rod A. Wing,Ralph A. Dean,Yeisoo Yu,Andrey Zharkikh,Richard Shen,Sudhir Sahasrabudhe,Alun Thomas,Rob Cannings,Alexander Gutin,Dmitry Pruss,Julia Reid,Sean V. Tavtigian,J.T. Mitchell,Glenn Eldredge,Terri Scholl,Rose Mary Miller,Satish Bhatnagar,Nils Adey,Todd Rubano,Nadeem Tusneem,Rosann Robinson,Jane Feldhaus,Teresita Macalma,Arnold R. Oliphant,Steven P. Briggs +54 more
TL;DR: A draft sequence of the rice genome for the most widely cultivated subspecies in China, Oryza sativa L. ssp.indica, by whole-genome shotgun sequencing is produced, with a large proportion of rice genes with no recognizable homologs due to a gradient in the GC content of rice coding sequences.
Journal ArticleDOI
The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.
Sean V. Tavtigian,Jacques Simard,Johanna M. Rommens,Fergus J. Couch,Donna M Shattuck-Eidens,Susan L. Neuhausen,Sofia D. Merajver,Steinunn Thorlacius,Kenneth Offit,Dominique Stoppa-Lyonnet,Carole Bélanger,Russell Bell,Simin Berry,Robert Bogden,Qian Chen,Thaylon Davis,Martine Dumont,Cheryl Frye,T. Hattier,Srikanth Jammulapati,Teresa Janecki,Ping Jiang,Robert Kehrer,J.-F. Leblanc,J.T. Mitchell,Jodi Mcarthur-Morrison,K. Nguyen,Yi Peng,Chantal Samson,Marianne Schroeder,S.C. Snyder,Linda Steele,M. Stringfellow,C. Stroup,Bradley D. Swedlund,J. Swense,David H. F. Teng,Alun Thomas,T.D. Tran,Martine Tranchant,Jane Weaver-Feldhaus,Alexander K. C. Wong,Hiroaki Shizuya,Jorunn E. Eyfjord,Lisa A. Cannon-Albright,Fernand Labrie,Mark H. Skolnick,Mark H. Skolnick,Barbara L. Weber,Alexander Kamb,David E. Goldgar,David E. Goldgar +51 more
TL;DR: The complete coding sequence and exonic structure of BRCA2 is determined, and its pattern of expression is examined, and a mutational analysis of B RCA2 in families selected on the basis of linkage analysis and/or the presence of one or more cases of male breast cancer is reported.
Journal ArticleDOI
Comprehensive statistical study of 452 BRCA1 missense substitutions with classification of eight recurrent substitutions as neutral
Sean V. Tavtigian,Amie M. Deffenbaugh,Luo Yin,Thaddeus Judkins,Thomas Scholl,Paul B. Samollow,Deepika de Silva,Andrey Zharkikh,Alun Thomas +8 more
TL;DR: Odds ratios estimated for sets of substitutions grouped by A-GVGD scores are consistent with the hypothesis that most unclassified substitutions that are within the cross-species range of variation at their position in BRCA1 are also neutral.
Journal ArticleDOI
A candidate prostate cancer susceptibility gene at chromosome 17p.
Sean V. Tavtigian,Jacques Simard,David H. F. Teng,Vicki Abtin,Michelle Baumgard,Audrey Beck,Nicola J. Camp,Nicola J. Camp,Arlene Carillo,Yang Chen,Priya Dayananth,Marc Desrochers,Martine Dumont,James M. Farnham,David A. Frank,Cheryl Frye,Siavash Ghaffari,Jamila Gupte,Rong Hu,Diana Iliev,Teresa Janecki,Edward N. Kort,Kirsten Laity,Amber Leavitt,Gilles Leblanc,Jodi Mcarthur-Morrison,Amy Pederson,Brandon Penn,Kelly T. Peterson,Julia Reid,Sam Richards,Marianne Schroeder,Richard D. Smith,Sarah C. Snyder,Brad Swedlund,Jeff Swensen,Alun Thomas,Martine Tranchant,Ann Marie Woodland,Fernand Labrie,Mark H. Skolnick,Susan L. Neuhausen,Johanna M. Rommens,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright +44 more
TL;DR: A genome-wide scan of large, high-risk pedigrees from Utah has provided evidence for linkage to a locus on chromosome 17p, identifying a gene, ELAC2, harboring mutations (including a frameshift and a nonconservative missense change) that segregate with prostate cancer in two pedigree.
Journal ArticleDOI
Sequence analysis of BRCA1 and BRCA2: correlation of mutations with family history and ovarian cancer risk.
Thomas S. Frank,S A Manley,Olufunmilayo I. Olopade,Shelly Cummings,Judy Garber,Barbara A. Bernhardt,Karen H. Antman,Donna Russo,Marie Wood,L Mullineau,Claudine Isaacs,Beth N. Peshkin,Saundra S. Buys,Vickie L. Venne,Peter T. Rowley,S Loader,Kenneth Offit,Mark E. Robson,Heather Hampel,D Brener,Eric P. Winer,Shelly Clark,Bernhard H. F. Weber,Louise C. Strong,Alun Thomas +24 more
TL;DR: Analysis of these genes should be considered for women diagnosed with breast cancer who have a high probability of carrying a mutation according to the statistical model developed with these data.