Author
Alvaro Mailhos
Other affiliations: Max Planck Society
Bio: Alvaro Mailhos is an academic researcher from University of the Republic. The author has contributed to research in topics: Medicine & Homeobox. The author has an hindex of 8, co-authored 15 publications receiving 2653 citations. Previous affiliations of Alvaro Mailhos include Max Planck Society.
Papers
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University of California, Santa Barbara1, University of Texas at Austin2, University of Wrocław3, Dresden University of Technology4, University of Tartu5, Gulu University6, Middle East University7, Stockholm University8, University of the Punjab9, University of Nigeria, Nsukka10, Istanbul University11, Franklin & Marshall College12, Norwegian University of Science and Technology13, University of Algiers14, Australian National University15, Russian Academy of Sciences16, Russian State University for the Humanities17, İzmir University of Economics18, University of Social Sciences and Humanities19, Université catholique de Louvain20, Ankara University21, Pontifical Catholic University of Peru22, Cumhuriyet University23, University of the Republic24, ISCTE – University Institute of Lisbon25, The Chinese University of Hong Kong26, National Autonomous University of Mexico27, University of Pécs28, University of Constantine the Philosopher29, University of Maribor30, University of Zagreb31, University of Malaya32, Central University of Finance and Economics33, University of Crete34, University of Primorska35, Institute of Molecular and Cell Biology36, University of Amsterdam37, Catholic University of the Sacred Heart38, VU University Amsterdam39, University of Granada40, University of Delhi41, University of Havana42, Pontifical Catholic University of Rio de Janeiro43, University of Vienna44, Universiti Utara Malaysia45, Vilnius University46, University of British Columbia47, University of Sussex48, Romanian Academy49, Slovak Academy of Sciences50, Comenius University in Bratislava51, University of Monterrey52, SAS Institute53, DHA Suffa University54, Pontifical Catholic University of Chile55, South-West University "Neofit Rilski"56, University of São Paulo57, Kyung Hee University58, University of Ljubljana59
TL;DR: This work combines this large cross-cultural sample with agent-based models to compare eight hypothesized models of human mating markets and finds that this cross-culturally universal pattern of mate choice is most consistent with a Euclidean model of mate preference integration.
Abstract: Humans express a wide array of ideal mate preferences. Around the world, people desire romantic partners who are intelligent, healthy, kind, physically attractive, wealthy, and more. In order for these ideal preferences to guide the choice of actual romantic partners, human mating psychology must possess a means to integrate information across these many preference dimensions into summaries of the overall mate value of their potential mates. Here we explore the computational design of this mate preference integration process using a large sample of n = 14,487 people from 45 countries around the world. We combine this large cross-cultural sample with agent-based models to compare eight hypothesized models of human mating markets. Across cultures, people higher in mate value appear to experience greater power of choice on the mating market in that they set higher ideal standards, better fulfill their preferences in choice, and pair with higher mate value partners. Furthermore, we find that this cross-culturally universal pattern of mate choice is most consistent with a Euclidean model of mate preference integration.
1,827 citations
TL;DR: The isolation of a sequence-related gene referred to as Six3 is reported, which is one of the most anterior homeobox gene reported to date and supports the idea that mammals and insects share control genes such as eyeless/Pax6 and also possibly other members of the regulatory cascade required for eye morphogenesis.
Abstract: The Drosophila sine oculis homeobox-containing gene is known to play an essential role in controlling the initial events of pattern formation in the eye disc and is also required for the development of other parts of the fly visual system including the optic lobes. In this paper, we report the isolation of a sequence-related gene referred to as Six3. Based on its amino acid sequence, this gene can be included in the new Six/sine oculis subclass of homeobox genes. Early on, Six3 expression is restricted to the anterior neural plate including areas that later will give rise to ectodermal and neural derivatives. Later, once the longitudinal axis of the brain bends, Six3 mRNA is also found in structures derived from the anterior neural plate: ectoderm of nasal cavity, olfactory placode and Rathke9s pouch, and also the ventral forebrain including the region of the optic recess, hypothalamus and optic vesicles. Based on this expression pattern, we conclude that Six3 is one of the most anterior homeobox gene reported to date. The high sequence similarity of Six3 with the Drosophila sine oculis, and its expression during eye development, suggests that this gene is the likely murine homologue. This finding supports the idea that mammals and insects share control genes such as eyeless/Pax6 (Halder, G., Callaerts, P. and Gehring, W. J. (1995) Science 267, 1788–1792), and also possibly other members of the regulatory cascade required for eye morphogenesis. In Small eye (Pax6) mouse mutants Six3 expression is not affected. Finally, based on the chromosomal localization and the expression pattern of the mouse Six3 gene, the human Six3 cognate could be a good candidate to be at least one of the genes affected in patients with holoprosencephaly type 2 due to an interstitial deletion of 2p21-p22. This region shares a homology with the distal region of mouse chromosome 17 where Six3 has been mapped.
690 citations
University of California, Santa Barbara1, University of Texas at Austin2, Dresden University of Technology3, University of Wrocław4, Opole University5, University of Tartu6, Gulu University7, Middle East University8, Stockholm University9, University of the Punjab10, University of Nigeria, Nsukka11, Istanbul University12, Franklin & Marshall College13, Norwegian University of Science and Technology14, University of Algiers15, Australian National University16, Russian State University for the Humanities17, Russian Academy of Sciences18, İzmir University of Economics19, University of Social Sciences and Humanities20, Université catholique de Louvain21, Ankara University22, Pontifical Catholic University of Peru23, Cumhuriyet University24, University of the Republic25, ISCTE – University Institute of Lisbon26, The Chinese University of Hong Kong27, National Autonomous University of Mexico28, University of Pécs29, University of Maribor30, University of Zagreb31, University of Malaya32, Central University of Finance and Economics33, University of Crete34, University of Primorska35, University of Amsterdam36, Catholic University of the Sacred Heart37, VU University Amsterdam38, University of Granada39, University of Delhi40, University of Havana41, Pontifical Catholic University of Rio de Janeiro42, University of Vienna43, Universiti Utara Malaysia44, Vilnius University45, University of British Columbia46, Centre national de la recherche scientifique47, Romanian Academy48, Comenius University in Bratislava49, Slovak Academy of Sciences50, University of Monterrey51, DHA Suffa University52, Pontifical Catholic University of Chile53, South-West University "Neofit Rilski"54, University of São Paulo55, Kyung Hee University56, University of Ljubljana57
TL;DR: Using a new 45-country sample (N = 14,399), this work attempted to replicate classic studies and test both the evolutionary and biosocial role perspectives, finding neither pathogen prevalence nor gender equality robustly predicted sex differences or preferences across countries.
Abstract: Considerable research has examined human mate preferences across cultures, finding universal sex differences in preferences for attractiveness and resources as well as sources of systematic cultural variation. Two competing perspectives-an evolutionary psychological perspective and a biosocial role perspective-offer alternative explanations for these findings. However, the original data on which each perspective relies are decades old, and the literature is fraught with conflicting methods, analyses, results, and conclusions. Using a new 45-country sample (N = 14,399), we attempted to replicate classic studies and test both the evolutionary and biosocial role perspectives. Support for universal sex differences in preferences remains robust: Men, more than women, prefer attractive, young mates, and women, more than men, prefer older mates with financial prospects. Cross-culturally, both sexes have mates closer to their own ages as gender equality increases. Beyond age of partner, neither pathogen prevalence nor gender equality robustly predicted sex differences or preferences across countries.
129 citations
TL;DR: Data suggest that, contrary to what is found for the majority of the more complex metazoans, Platyhelminthes contain few homeobox genes belonging to the Antennapedia-type.
43 citations
University of California, Santa Barbara1, California State University, Fullerton2, University of Texas at Austin3, Dresden University of Technology4, University of Wrocław5, University of Tartu6, Gulu University7, Middle East University8, Stockholm University9, University of the Punjab10, University of Nigeria, Nsukka11, Istanbul University12, Franklin & Marshall College13, Norwegian University of Science and Technology14, University of Algiers15, Catholic University of the Sacred Heart16, Australian National University17, Russian Academy of Sciences18, Russian State University for the Humanities19, İzmir University of Economics20, University of Social Sciences and Humanities21, Université catholique de Louvain22, Ankara University23, Pontifical Catholic University of Peru24, Cumhuriyet University25, University of the Republic26, ISCTE – University Institute of Lisbon27, The Chinese University of Hong Kong28, National Autonomous University of Mexico29, University of Pécs30, University of Constantine the Philosopher31, University of Maribor32, University of Zagreb33, University of Malaya34, Central University of Finance and Economics35, University of Crete36, University of Primorska37, University of Amsterdam38, VU University Amsterdam39, University of Granada40, University of Delhi41, University of Havana42, Pontifical Catholic University of Rio de Janeiro43, University of Vienna44, Vilnius University45, University of Minho46, University of Sussex47, Romanian Academy48, Comenius University in Bratislava49, Slovak Academy of Sciences50, SAS Institute51, DHA Suffa University52, Pontifical Catholic University of Chile53, South-West University "Neofit Rilski"54, University of São Paulo55, Kyung Hee University56, University of Ljubljana57
TL;DR: This work uses agent-based models to demonstrate that assortative mating causes the evolution of a positive manifold of desirability, d, such that an individual who is desirable as a mate along any one dimension tends to be desirable across all other dimensions.
27 citations
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01 Jan 2010
TL;DR: In this paper, the authors show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait, revealing patterns with important implications for genetic studies of common human diseases and traits.
Abstract: Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P < 0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.
1,751 citations
TL;DR: By targeted expression of the ey complementary DNA in various imaginal disc primordia of Drosophila, ectopic eye structures were induced on the wings, the legs, and on the antennae and support the proposition that ey is the master control gene for eye morphogenesis.
Abstract: The Drosophila gene eyeless (ey) encodes a transcription factor with both a paired domain and a homeodomain. It is homologous to the mouse Small eye (Pax-6) gene and to the Aniridia gene in humans. These genes share extensive sequence identity, the position of three intron splice sites is conserved, and these genes are expressed similarly in the developing nervous system and in the eye during morphogenesis. Loss-of-function mutations in both the insect and in the mammalian genes have been shown to lead to a reduction or absence of eye structures, which suggests that ey functions in eye morphogenesis. By targeted expression of the ey complementary DNA in various imaginal disc primordia of Drosophila, ectopic eye structures were induced on the wings, the legs, and on the antennae. The ectopic eyes appeared morphologically normal and consisted of groups of fully differentiated ommatidia with a complete set of photoreceptor cells. These results support the proposition that ey is the master control gene for eye morphogenesis. Because homologous genes are present in vertebrates, ascidians, insects, cephalopods, and nemerteans, ey may function as a master control gene throughout the metazoa.
1,567 citations
TL;DR: Differences in the expression topography of Tbr‐1 and Emx‐1 suggest the existence of a novel “ventral pallium” subdivision, which is an EmX‐1‐negative pallial territory intercalated between the striatum and the lateral pallium.
Abstract: Pallial and subpallial morphological subdivisions of the developing chicken telencephalon were examined by means of gene markers, compared with their expression pattern in the mouse. Nested expression domains of the genes Dlx-2 and Nkx-2.1, plus Pax-6-expressing migrated cells, are characteristic for the mouse subpallium. The genes Pax-6, Tbr-1, and Emx-1 are expressed in the pallium. The pallio-subpallial boundary lies at the interface between the Tbr-1 and Dlx-2 expression domains. Differences in the expression topography of Tbr-1 and Emx-1 suggest the existence of a novel “ventral pallium” subdivision, which is an Emx-1-negative pallial territory intercalated between the striatum and the lateral pallium. Its derivatives in the mouse belong to the claustroamygdaloid complex. Chicken genes homologous to these mouse genes are expressed in topologically comparable patterns during development. The avian subpallium, called “paleostriatum,” shows nested Dlx-2 and Nkx-2.1 domains and migrated Pax-6-positive neurons; the avian pallium expresses Pax-6, Tbr-1, and Emx-1 and also contains a distinct Emx-1-negative ventral pallium, formed by the massive domain confusingly called “neostriatum.” These expression patterns extend into the septum and the archistriatum, as they do into the mouse septum and amygdala, suggesting that the concepts of pallium and subpallium can be extended to these areas. The similarity of such molecular profiles in the mouse and chicken pallium and subpallium points to common sets of causal determinants. These may underlie similar histogenetic specification processes and field homologies, including some comparable connectivity patterns. J. Comp. Neurol. 424: 409 ‐ 438, 2000. © 2000 Wiley-Liss, Inc.
918 citations
TL;DR: It is demonstrated that Pax6 directly controls the transcriptional activation of Retinogenic bHLH factors that bias subsets of RPCs toward the different retinal cell fates, thereby mediating the full retinogenic potential of RPC's.
873 citations
TL;DR: The authors investigated whether a default mechanism of neural specification could regulate the acquisition of neural stem cell identity directly from embryonic stem (ES) cells, and found that the default mechanism is negatively regulated by TGFβ-related signaling.
796 citations