Alyson Fox

TL;DR: It is demonstrated that Balb/c mice lacking the GABA(B(1)) subunit are viable, exhibit spontaneous seizures, hyperalgesia, hyperlocomotor activity, and memory impairment, and casts doubt on the existence of proposed receptor subtypes.

TL;DR: An analysis of pain related behaviours in two models of OA in the rat: partial medial meniscectomy and iodoacetate injection provides a basis for studies on the mechanisms of pain in OA, and for development of novel therapeutic analgesics.

TL;DR: It is shown that RNAi can block a pathophysiological pain response and provide relief from neuropathic pain in a rat disease model by down regulating an endogenous, neuronally expressed gene.

TL;DR: Examination of the expression of the sensory neuron‐specific cation channel Vanilloid Receptor 1 (VR1), an important transducer of noxious stimuli, in three models of nerve injury in the rat found that VR1‐IR persisted in the transected sciatic nerve proximal to the lesion, despite its down‐regulation in the damaged neuronal somata.

TL;DR: The data show that VR1 antagonists have antihyperalgesic activity in animal models of chronic inflammatory and neuropathic pain, and illustrate species differences in the in vivo pharmacology of VR1 that correlate with differences in pharmacology previously seen in vitro.