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Amaia Azqueta
Researcher at University of Navarra
Publications - 21
Citations - 985
Amaia Azqueta is an academic researcher from University of Navarra. The author has contributed to research in topics: Comet assay & Cytotoxicity. The author has an hindex of 16, co-authored 21 publications receiving 916 citations. Previous affiliations of Amaia Azqueta include Counterintelligence Field Activity & University of the Republic.
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Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships.
Mauricio Cabrera,Macarena Simoens,Gabriela Falchi,M. Laura Lavaggi,Oscar E. Piro,Eduardo E. Castellano,Anabel Vidal,Amaia Azqueta,Antonio Monge,Adela López de Cerain,Gabriel Sagrera,Gustavo Seoane,Hugo Cerecetto,Mercedes González +13 more
TL;DR: A series of synthetic chalcones, flavanones, and flavones has been synthesized and evaluated for antitumor activity against the human kidney carcinoma cells TK-10, human mammary adenocarcinoma cells MCF-7 (estrogen receptor-positive), and human colon adenOCarcinomas cells HT-29.
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Vanadium(V) complexes with salicylaldehyde semicarbazone derivatives bearing in vitro anti-tumor activity toward kidney tumor cells (TK-10): crystal structure of [VVO2(5-bromosalicylaldehyde semicarbazone)].
Pabla Noblía,Marisol Vieites,Beatriz S. Parajón-Costa,E. J. Baran,Hugo Cerecetto,Patricia Draper,Mercedes González,Oscar E. Piro,Eduardo E. Castellano,Amaia Azqueta,Adela López de Cerain,Antonio Monge-Vega,Dinorah Gambino +12 more
TL;DR: Results showed that structural modifications on the semicarbazone moiety could have a significant effect on the anti-tumor activity of the vanadium complexes, and no apparent correlation could be demonstrated between reduction potentials of the complexes and their anti-Tumor activities.
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Oxidative DNA damage induced by Ochratoxin A in the HK-2 human kidney cell line: evidence of the relationship with cytotoxicity.
TL;DR: Data suggest that OTA is not acting as a direct genotoxic carcinogen and that oxidative stress is implicated in the genotoxicity and cytotoxicity observed in these human renal cells.
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Indazole N-oxide derivatives as antiprotozoal agents: synthesis, biological evaluation and mechanism of action studies
Alejandra Gerpe,Gabriela Aguirre,Lucía Boiani,Hugo Cerecetto,Mercedes González,Claudio Olea-Azar,Carolina Rigol,Juan Diego Maya,Antonio Morello,Oscar E. Piro,Vicente J. Arán,Amaia Azqueta,Adela López de Cerain,Antonio Monge,María Antonieta Rojas,Gloria Yaluff +15 more
TL;DR: 3-Cyano-2-(4-iodophenyl)-2H-indazole N1-oxide exhibited interesting antichagasic activity on the two parasitic strains and theTwo parasitic stages evaluated, besides its trypanocidal activity.
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In vitro gene expression data supporting a DNA non-reactive genotoxic mechanism for ochratoxin A.
TL;DR: Results support a DNA non-reactive mechanism of OTA genotoxicity, and up-regulation of genes implicated in DNA damage response, as cell cycle control or apoptosis, was not detected at any exposure time.