Amanda Woodward-Davis

TL;DR: For example, resident memory T cells (Trm) as mentioned in this paper were found to persist in the brain after removal of a virus from the tissue and after adoptive transfer into the bloodstream of antigen-challenged recipients.

TL;DR: Comparing the gene expression profiles of Trm cells isolated from the brain with those of circulating memory T cellsisolated from the spleen after an acute virus infection indicates that Trm Cells are a distinct memory T cell population disconnected from the circulatingMemory T cell pool and display a unique molecular signature that likely results in optimal survival and function within their local environment.

TL;DR: An innate role for memoryCD8 T cells in the early immune response before the onset of a de novo generated, antigen-specific CD8 T cell response is suggested.

TL;DR: It is demonstrated that inflammatory cytokines were sufficient to induce CTLA-4 expression on the MAIT cell surface in the absence of TCR signals, and it is proposed that this mechanism serves to limitMAIT cell–mediated tissue damage.

TL;DR: In this article, the authors examined the T cell compartment in healthy human cervicovaginal tissue (CVT) and found that most CD8 T cells were granzyme B+ and TCF-1- to address if this phenotype is driven by CVT tissue residence, using a mouse model to control for environmental factors.