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Amandine Pignarre
Researcher at University of Rennes
Publications - 6
Citations - 113
Amandine Pignarre is an academic researcher from University of Rennes. The author has contributed to research in topics: Gene & Immunoglobulin class switching. The author has an hindex of 4, co-authored 5 publications receiving 79 citations. Previous affiliations of Amandine Pignarre include French Institute of Health and Medical Research.
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Journal ArticleDOI
Cell-Cycle-Dependent Reconfiguration of the DNA Methylome during Terminal Differentiation of Human B Cells into Plasma Cells.
Gersende Caron,Mourad Hussein,Mourad Hussein,Marta Kulis,Céline Delaloy,Céline Delaloy,Fabrice Chatonnet,Amandine Pignarre,Amandine Pignarre,Stéphane Avner,Stéphane Avner,Maud Lemarié,Maud Lemarié,Elise A. Mahé,Elise A. Mahé,Núria Verdaguer-Dot,Ana C. Queirós,Karin Tarte,José I. Martín-Subero,Gilles Salbert,Gilles Salbert,Thierry Fest +21 more
TL;DR: Remarkably, hydroxymethylation of PRDM1, a gene essential for plasma cell fate, was coupled to progression in S phase, revealing an intricate connection among cell cycle, DNA (hydroxy)methylation, and cell fate determination.
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The hydroxymethylome of multiple myeloma identifies FAM72D as a 1q21 marker linked to proliferation
Fabrice Chatonnet,Amandine Pignarre,Aurélien A. Sérandour,Gersende Caron,Stéphane Avner,Nicolas Robert,Alboukadel Kassambara,Audrey Laurent,Maud Bizot,Xabier Agirre,Felipe Prosper,José I. Martín-Subero,Jérôme Moreaux,Thierry Fest,Gilles Salbert +14 more
TL;DR: The definition of a MM-specific 5hmC signature was identified and it was uncovered that FAM72D functions as part of the FOXM1 transcription factor network controlling cell proliferation and survival and an increased sensitivity of cells expressing high levels ofFOXM1 and FAM72 to epigenetic drugs targeting histone deacetylases and DNA methyltransferases.
Journal ArticleDOI
Locus suicide recombination actively occurs on the functionally rearranged IgH allele in B-cells from inflamed human lymphoid tissues.
Iman Dalloul,François Boyer,Zeinab Dalloul,Amandine Pignarre,Gersende Caron,Thierry Fest,Fabrice Chatonnet,Céline Delaloy,Anne Durandy,Robin Jeannet,Emilie Lereclus,Hend Boutouil,Jean-Claude Aldigier,Sophie Péron,Sandrine Le Noir,Jeanne Cook-Moreau,Michel Cogné,Michel Cogné +17 more
TL;DR: It is shown that AID-mediated LSR is evolutionarily conserved and also actively occurs in humans, providing an activation-induced cell death pathway in multiple conditions of B-cell activation.
Journal ArticleDOI
Plasmablasts derive from CD23– activated B cells after the extinction of IL-4/STAT6 signaling and IRF4 induction
Amandine Pignarre,Fabrice Chatonnet,Gersende Caron,Marion Haas,Fabienne Desmots,Thierry Fest +5 more
TL;DR: The results provide an unprecedented genomic characterization of the fate decision between activated B cells and plasmablast, which gives new insights in pathological mechanisms driving lymphoma biology.
Journal ArticleDOI
Pivotal role of PIM2 kinase in plasmablast generation and plasma cell survival, opening new treatment options in myeloma.
Marion Bertrand-de Haas,Gersende Caron,Fabrice Chatonnet,Stéphane Manenti,Elina Alaterre,Julie Devin,Celine Delaloy,Giulia Bertolin,Roselyne Viel,Amandine Pignarre,Francisco Llamas Gutierrez,Anne Marchalot,Olivier Decaux,Karin Tarte,Laurent Delpy,Jérôme Moreaux,Thierry Fest +16 more
TL;DR: A cell-autonomous function that links kinase activity to the PBs' newly acquired secretion ability and the adaptability observed in both normal and malignant PCs is highlighted, and should prompt the reconsideration of PIM2 as a therapeutic target in multiple myeloma.