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Amar K. Chandra

Other affiliations: Tripura University
Bio: Amar K. Chandra is an academic researcher from University of Calcutta. The author has contributed to research in topics: Thyroid & Goiter. The author has an hindex of 21, co-authored 71 publications receiving 1161 citations. Previous affiliations of Amar K. Chandra include Tripura University.


Papers
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TL;DR: Raw, boiled and cooked extracts of the plants showed anti-thyroidal activity in vitro, and excess iodide reversed the anti-TPO activity to same extent but could not neutralise it.
Abstract: from iodide. The anti-TPO activities of the plants were assayed after adding raw, boiled and cooked extracts in the assay medium with and without extra iodide. Relative antithyroidal potency of the plant extracts was also evaluated in terms of the concentration (IC 50 ) necessary to produce 50 per cent inhibition of TPO activity. PTU equivalence of the plant foods was also determined. Results: Cabbage and cauliflower were rich in glucosinolates, bamboo shoot and cassava were rich in cyanogenic glucosides, mustard, turnip and radish were relatively rich in thiocyanate however all the constituents were present in each plant. Boiled extracts showed maximum inhibition of TPO activity followed by cooked and raw extracts. Excess iodide was found relatively effective for raw extract but less effective for boiled and cooked extracts in reversing anti-TPO activity. Inhibition constant (IC 50 ) was found highest with bamboo shoot and least with cabbage. Interpretation & conclusion: Raw, boiled and cooked extracts of the plants showed anti-thyroidal activity in vitro. Excess iodide reversed the anti-TPO activity to same extent but could not neutralise it.

80 citations

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TL;DR: Simultaneous oral supplementation of vitamin E in Cr exposed rats showed less oxidative damage and restored the otherwise altered testicular activities and Epididymal sperm number was also restored in vitamin E-supplemented group than Cr induced rats.

61 citations

Journal Article
TL;DR: The results suggests that the changes that occurred after excessive magnesium in testis were not for the enhanced adrenocortical activities or for the generation of oxidative stress in reproductive organs, but for the direct action of excess magnesium on male gonads.
Abstract: The available information on the effect of excess dietary magnesium on male reproduction is inadequate, though consumption of hard water rich in magnesium salt is not uncommon in many geographical areas. The present study has thus been undertaken to evaluate the morphological as well as cytological and functional changes in testis of magnesium administered sexually mature male Wistar rats. Significant increase in the activities of androgenic enzymes viz. delta(5)3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase with concomitant increase in serum testosterone level, followed by progressive development in cytoarchitechture of genital organs, without any significant alteration in quantitative spermatogenesis were observed. The results were more marked in the groups treated for longer duration. The results further suggests that the changes that occurred after excessive magnesium in testis were not for the enhanced adrenocortical activities or for the generation of oxidative stress in reproductive organs, but for the direct action of excess magnesium on male gonads. Magnesium supplementation thus has an apparent beneficial effect on male gonadal system.

59 citations

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TL;DR: The results suggest that an increase in free radical formation relative to loss of antioxidant defense system during vanadium exposure may render testis more susceptible to oxidative damage leading to their functional inactivation.

58 citations

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TL;DR: It is suggested that curcumin may have a protective role against chromium(VI) induced oxidative damage in male reproductive system.

57 citations


Cited by
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TL;DR: The overall findings indicate that rats grow rapidly during their childhood and become sexually mature at about the sixth week, but attain social maturity 5-6 months later, which must be taken into consideration while analyzing the results or selecting the dose of any research in rats when age is a crucial factor.
Abstract: By late 18th or early 19th century, albino rats became the most commonly used experimental animals in numerous biomedical researches, as they have been recognized as the preeminent model mammalian system. But, the precise correlation between age of laboratory rats and human is still a subject of debate. A number of studies have tried to detect these correlations in various ways, But, have not successfully provided any proper association. Thus, the current review attempts to compare rat and human age at different phases of their life. The overall findings indicate that rats grow rapidly during their childhood and become sexually mature at about the sixth week, but attain social maturity 5-6 months later. In adulthood, every day of the animal is approximately equivalent to 34.8 human days (i.e., one rat month is comparable to three human years). Numerous researchers performed experimental investigations in albino rats and estimated, in general, while considering their entire life span, that a human month resembles every-day life of a laboratory rat. These differences signify the variations in their anatomy, physiology and developmental processes, which must be taken into consideration while analyzing the results or selecting the dose of any research in rats when age is a crucial factor.

1,408 citations

01 Jan 2007
TL;DR: The terms "antioxidant", "oxidative stress" and "oxoidative damage" are widely used but rarely defined as discussed by the authors, and a brief review attempts to define them and to examine the ways in which oxidative stress and oxidative damage can affect cell behaviour both in vivo and in cell culture, using cancer as an example.
Abstract: The terms 'antioxidant', 'oxidative stress' and 'oxidative damage' are widely used but rarely defined. This brief review attempts to define them and to examine the ways in which oxidative stress and oxidative damage can affect cell behaviour both in vivo and in cell culture, using cancer as an example.

1,309 citations

01 Jan 2016
TL;DR: Methods Of Enzymatic Analysis is universally compatible behind any devices to read, and in the authors' digital library an online admission to it is set as public appropriately so you can download it instantly.
Abstract: Rather than enjoying a fine ebook as soon as a mug of coffee in the afternoon, instead they juggled when some harmful virus inside their computer. Methods Of Enzymatic Analysis is clear in our digital library an online admission to it is set as public appropriately you can download it instantly. Our digital library saves in complex countries, allowing you to get the most less latency period to download any of our books considering this one. Merely said, the Methods Of Enzymatic Analysis is universally compatible behind any devices to read.

1,136 citations

Journal ArticleDOI
TL;DR: The testes contain an elaborate array of antioxidant enzymes and free radical scavengers to ensure that the twin spermatogenic and steroidogenic functions of this organ are not impacted by oxidative stress.
Abstract: Spermatogenesis is an extremely active replicative process capable of generating approxi mately 1,000 sperm a second. The high rates of cell division inherent in this process imply correspondingly high rates of mitochondrial oxygen consumption by the germinal epithelium. However, the poor vascularization of the testes means that oxygen tensions in this tissue are low1 and that competition for this vital element within the testes is extremely intense. Since both spermatogenesis2 and Leydig cell steroidogenesis3,4 are vulnerable to oxidative stress, the low oxygen tension that characterizes this tissue may be an important component of the mechanisms by which the testes protects itself from free radical-mediated damage. In addition, the testes contain an elaborate array of antioxidant enzymes and free radical scavengers to ensure that the twin spermatogenic and steroidogenic functions of this organ are not impacted by oxidative stress. These antioxidant defence systems are of major importance because peroxidative damage is currently regarded as the single most important cause of impaired testicular function underpinning the pathological consequences of a wide range of conditions from testicular torsion to diabetes and xenobiotic exposure. This chapter sets out the specific nature of these antioxidant defence systems and also reviews the factors that have been found to impair their activity, precipitating a state of oxidative stress in the testes and impairing the latter’s ability to produce viable spermatozoa capable of initiating and supporting embryonic development.

731 citations