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Amar Sahay
Researcher at Harvard University
Publications - 49
Citations - 7750
Amar Sahay is an academic researcher from Harvard University. The author has contributed to research in topics: Neurogenesis & Dentate gyrus. The author has an hindex of 30, co-authored 46 publications receiving 6645 citations. Previous affiliations of Amar Sahay include Broad Institute & Johns Hopkins University School of Medicine.
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Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation.
Amar Sahay,Kimberly N. Scobie,Alexis S. Hill,C. O'Carroll,Mazen A. Kheirbek,Nesha S. Burghardt,André A. Fenton,Alex Dranovsky,René Hen +8 more
TL;DR: It is shown that inducible genetic expansion of the population of adult-born neurons through enhancing their survival improves performance in a specific cognitive task in which two similar contexts need to be distinguished, which is indicative of enhanced pattern separation.
Journal ArticleDOI
Adult hippocampal neurogenesis in depression.
Amar Sahay,René Hen +1 more
TL;DR: The functional differentiation of the hippocampus along the septo-temporal axis is revisited and it is suggested that neurogenesis in the ventral dentate gyrus may be preferentially involved in regulation of emotion.
Journal ArticleDOI
Dedifferentiation of committed epithelial cells into stem cells in vivo
Purushothama Rao Tata,Hongmei Mou,Ana Pardo-Saganta,Rui Zhao,Mythili Prabhu,Brandon M. Law,Vladimir Vinarsky,Josalyn L. Cho,Sylvie Breton,Amar Sahay,Benjamin D. Medoff,Jayaraj Rajagopal +11 more
TL;DR: Evidence is presented that differentiated airway epithelial cells can revert into stable and functional stem cells in vivo, and this capacity of committed cells to dedifferentiate into stem cells may have a more general role in the regeneration of many tissues and in multiple disease states, notably cancer.
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Pattern separation: a common function for new neurons in hippocampus and olfactory bulb.
TL;DR: It is proposed that new granule cells in the OB and DG may function as modulators of principal neurons to influence pattern separation and that adult neurogenesis constitutes an adaptive mechanism to optimally encode contextual or olfactory information.
Journal ArticleDOI
Neuropilin-2 Is Required In Vivo for Selective Axon Guidance Responses to Secreted Semaphorins
Roman J. Giger,Jean-François Cloutier,Amar Sahay,Rab K. Prinjha,Dorothy V. Levengood,Stephen E. Moore,Susan J. Pickering,David Simmons,Sohaila Rastan,Frank S. Walsh,Alex L. Kolodkin,David D. Ginty,Martin Geppert +12 more
TL;DR: The results show that Npn-2 is a selective receptor for class 3 semaphorins in vivo and thatNpn-1 and NPN-2 are required for development of an overlapping but distinct set of CNS and PNS projections.