Ami Graham

TL;DR: It is shown that molecular recapitulations of three prototypical adaptations associated with the unsusceptible phenotype are each sufficient to promote resistant behavior and validate a multidisciplinary approach to examine the neurobiological mechanisms of variations in stress resistance.

TL;DR: It is shown that mice carrying a mutation in the Clock gene display an overall behavioral profile that is strikingly similar to human mania, including hyperactivity, decreased sleep, lowered depression-like behavior, lower anxiety, and an increase in the reward value for cocaine, sucrose, and medial forebrain bundle stimulation.

TL;DR: It is suggested that proper balance of histone acetylation is a crucial factor in the saliency of a given stimulus and that disruption of this balance is involved in the transition from an acute adaptive response to a chronic psychiatric illness.

TL;DR: A direct role is established for NFκB pathways in the NAc to regulate structural and behavioral plasticity to cocaine and the ability of previous cocaine exposure to increase an animal's preference for cocaine.

TL;DR: In this paper, the authors used RNA interference and viral-mediated gene transfer to knock down Clock expression specifically in the ventral tegmental area (VTA) of mice, and found that knockdown of Clock, particularly in the VTA, results in hyperactivity and a reduction in anxiety-related behavior, which is similar to the phenotype of the Clock Δ19 mice.