A
Amir Abdollahi
Researcher at German Cancer Research Center
Publications - 208
Citations - 7115
Amir Abdollahi is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 40, co-authored 175 publications receiving 5709 citations. Previous affiliations of Amir Abdollahi include University Hospital Heidelberg & Heidelberg University.
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Journal ArticleDOI
Endostatin's antiangiogenic signaling network
Amir Abdollahi,Philip Hahnfeldt,Christian Maercker,Hermann Josef Gröne,Juergen Debus,Wilhelm Ansorge,Judah Folkman,Lynn Hlatky,Peter E. Huber +8 more
TL;DR: It is here demonstrated that the set of gene expressions underlying the angiogenic balance in tissues can be molecularly reset en masse by a single protein, resulting in a unique alignment between the direction of gene regulation andAngiogenic status.
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Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis
Amir Abdollahi,Minglun Li,Minglun Li,Gong Ping,Gong Ping,Christian Plathow,Sophie Domhan,Sophie Domhan,Fabian Kiessling,Leslie B. Lee,Gerald McMahon,Hermann Josef Gröne,Kenneth E. Lipson,Peter E. Huber +13 more
TL;DR: It is indicated that inhibition of fibrogenesis, rather than inflammation, is critical to antifibrotic treatment and points the way to a potential new approach for treating idiopathic or therapy-related forms of lung fibrosis.
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Transcriptional Switch of Dormant Tumors to Fast-Growing Angiogenic Phenotype
Nava Almog,Lili Ma,Raktima Raychowdhury,Christian Schwager,Ralf Erber,Sarah Short,Lynn Hlatky,Peter Vajkoczy,Peter E. Huber,Judah Folkman,Amir Abdollahi +10 more
TL;DR: It is hypothesized that dormant tumors undergo a stable genetic reprogramming during their switch to the fast-growing phenotype, and novel dormancy-specific biomarkers such as H2BK and Eph receptor A5 (EphA5) were discovered.
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Inhibition of αvβ3 Integrin Survival Signaling Enhances Antiangiogenic and Antitumor Effects of Radiotherapy
Amir Abdollahi,David W. Griggs,Heike Zieher,Alexandra Roth,Kenneth E. Lipson,Rainer Saffrich,Hermann Josef Gröne,Dennis E. Hallahan,Ralph A. Reisfeld,Juergen Debus,Andreas G. Niethammer,Peter E. Huber +11 more
TL;DR: It is shown that combined treatment with S247, an Arg-Gly-Glu peptidomimetic antagonist of αvβ3 integrin, and external beam radiotherapy are beneficial in local tumor therapy and that the combination of integrin antagonists and radiotherapy represents a rational approach in local cancer therapy.
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Trimodal Cancer Treatment: Beneficial Effects of Combined Antiangiogenesis, Radiation, and Chemotherapy
Peter E. Huber,Marc Bischof,Jürgen Jenne,Sabine Heiland,Peter Peschke,Rainer Saffrich,Hermann Josef Gröne,Jürgen Debus,Kenneth E. Lipson,Amir Abdollahi +9 more
TL;DR: It is concluded that trimodal cancer therapy combining antiangiogenesis, chemotherapy, and radiotherapy has beneficial molecular and physiologic effects to emerge as a clinically relevant antitumor strategy.