Author
Amir Erfanparast
Bio: Amir Erfanparast is an academic researcher from Urmia University. The author has contributed to research in topics: (+)-Naloxone & Orofacial pain. The author has an hindex of 10, co-authored 28 publications receiving 370 citations.
Topics: (+)-Naloxone, Orofacial pain, Opioid, Histamine, Safranal
Papers
More filters
TL;DR: Anti-inflammatory and antinociceptive activities for crocin, safranal and diclofenac in carrageenan model of local inflammation and inflammatory pain were showed.
85 citations
TL;DR: Safranal and lansoprazole normalized gastric volume and pH, reduced gastric ulcer area and produced gastric protection, suggesting the involvement of anti-secretory, anti-oxidant,Anti-inflammatory and anti-apoptotic mechanisms in gastro-protective effect of safranal.
44 citations
TL;DR: Inhibition of oxidative stress pathway may be involved in improving effects of safranal and vitamin E on functions and histopathology of an injured peripheral nerve.
43 citations
TL;DR: The results of the present study indicate that at the level of the hippocampus, histamine through its H(1) and H(2) receptors, mediates orofacial region pain, and morphine via a naloxone-reversible mechanism produces analgesia.
34 citations
TL;DR: Results indicate that the activation of brain neuronal histamine at the levels of the hippocampus may produce antinociception, and may be mediated thorough its H(1) and H(2) receptors.
33 citations
Cited by
More filters
TL;DR: This paper is the thirty-seventh consecutive installment of the annual review of research concerning the endogenous opioid system and summarizes papers published during 2014 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists.
111 citations
TL;DR: A review found that the C. sativus and its main constituents such as safranal, crocins, and crocetin could be effective against various diseases because of their antioxidant, anti‐inflammation, and immunomodulatory effects.
Abstract: Crocus sativus L. (C. sativus), commonly known as saffron, is used as a food additive, preservative, and medicinal herb. Traditionally, it has been used as an alternative treatment for different diseases. C. sativus' medicinal effects are related to its major constituents like crocins, crocetin, and safranal. According to the literature, C. sativus and its constituents could be considered as an effective treatment for neurodegenerative disorders, coronary artery diseases, asthma, bronchitis, colds, fever, diabetes, and so on. Recently, numerous studies have reported such medicinal properties and found that the underlying mechanisms of action may be mediated by antioxidant, inflammatory, and immunomodulatory effects. C. sativus enhances the antioxidant capacity and acts as a free radical scavenger. As an antiinflammatory and immunomodulatory agent, it modulates inflammatory mediators, humoral immunity, and cell-mediated immunity responses. This review highlights in vitro and animal findings regarding antiinflammatory, antioxidant, and immunomodulatory effects of C. sativus and its constituents. Present review found that the C. sativus and its main constituents such as safranal, crocins, and crocetin could be effective against various diseases because of their antioxidant, anti-inflammation, and immunomodulatory effects. Copyright © 2016 John Wiley & Sons, Ltd.
109 citations
TL;DR: It is suggested that after randomised clinical trials, saffron may be implicated as a preventive or therapeutic agent against metabolic syndrome.
Abstract: Metabolic syndrome is a disorder which encompasses obesity, high blood glucose, high cholesterol levels and high blood pressure. Moreover, metabolic syndrome is considered as the most important risk factor for cardiovascular disease (CVD). CVD is the leading cause of mortality in the world for both men and women. Several chemical drugs are available to treat metabolic risk factors, but because of the safety, efficacy, cultural acceptability and lesser side effects, nowadays herbal therapy has a critical role in the treatment of these CVD risk factors. Crocus sativus L. (saffron) is a perennial herb that belongs to the Iridaceae family. Saffron is an extensively used food additive for its colour and taste and has been widely used in traditional as well as modern medicine to treat several illnesses including cardiovascular diseases. Most of the unique properties of this plant are attributed to the presence of three major components, including crocin, safranal and crocetin. It has been proved that saffron has an important role in the management of metabolic syndrome because of its marvelous activities including anti-diabetic, anti-obesity, hypotensive and hypolipidaemic properties. In this review article, we discuss the beneficial properties of saffron and its active components to treat different components of metabolic syndrome and most relevant animal and human studies regarding the use of this plant in cardiovascular disease, with focus on the metabolic risk factors. This review also suggests that after randomised clinical trials, saffron may be implicated as a preventive or therapeutic agent against metabolic syndrome. © 2016 Society of Chemical Industry.
105 citations
TL;DR: An attempt has been made to elucidate the molecular mode of action of various plant products, and synthetic drugs investigated in various preclinical and clinical tests in AD, and discusses current attempts to formulate a comprehensive CDMT strategy to counter complex pathogenesis in AD.
94 citations
TL;DR: In addition to W/O micro-emulsions, spontaneous method could be used for preparing stable O/W micro- emulsions and showed the high effect of PGPR on rheological properties.
94 citations