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Amit B. Patel

Bio: Amit B. Patel is an academic researcher from Sardar Vallabhbhai National Institute of Technology, Surat. The author has contributed to research in topics: Antimycobacterial & Quinazoline. The author has an hindex of 8, co-authored 18 publications receiving 144 citations. Previous affiliations of Amit B. Patel include Government College & Kadi Sarva Vishwavidyalaya.

Papers
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Journal ArticleDOI
TL;DR: Two series of bis(3, 5-dimethylpiperidinyl)-1,3,5-triazinyl)-N-(phenyl/benzothiazolyl)-acetamides were synthesized so as to investigate their antimicrobial and antimycobacterial actions.
Abstract: Two series of bis(3,5-dimethylpiperidinyl)-1,3,5-triazinyl)-N-(phenyl/benzothiazolyl)-acetamides were synthesized so as to investigate their antimicrobial and antimycobacterial actions. Intermediate 4-(4,6-bis(3,5-dimethylpiperidin-1-yl)-1,3,5-triazin-2-yl)aniline was synthesized by palladium-catalyzed Suzuki cross-coupling reaction to furnish C–C bond formation to s-triazine ring. Pharmacological screening against eight bacteria (S. aureus, B. cereus, E. coli, P. aeruginosa, K. pneumoniae, S. typhi, P. vulgaris, and S. flexneri), four fungi (A. niger, A. fumigatus, A. clavatus, and C. albicans), and Mycobacterium tuberculosis H37Rv was examined and the effects of various substituents on biological profiles (MIC, 1.56–50 μg/mL) of final analogues were investigated. Four (8c, 8i, 9d, 9j) of the final analogues displayed antimycobacterial activity (3.12–6.25 μg/mL) equipotent to standard drugs.

32 citations

Journal ArticleDOI
TL;DR: The best results were observed amongst the nicotinonitrile substituted s-triazine analogs and it could be a potential starting point to develop new lead compounds in the fight against M. tuberculosis H37Rv.

29 citations

Journal ArticleDOI
TL;DR: It was observed that, both benzonitrile and nicotinonitrile are essential to increase the different pharmacological activities as well as in vitro antimicrobial and anticancer efficacy against prostate cancer PC3 cells.

18 citations

Journal ArticleDOI
TL;DR: In this paper, a new series of 3-(5-sulfanyl-1,3,4-oxadiazol-2,yl)-2H-chromen-2-ones based on various substituted piperazines and piperidines incorporating a 1,3-5-triazine moiety are reported.
Abstract: Synthesis and antimicrobial activity of a new series of 3-(5-sulfanyl-1,3,4-oxadiazol-2-yl)-2H-chromen-2-ones based on various substituted piperazines and piperidines incorporating a 1,3,5-triazine moiety are reported in this article. 3-{5-[(4,6-dichloro-1,3,5-triazin-2-yl)sulfanyl]-1,3,4-oxadiazol-2-yl}-2H-chromen-2-one 3 was obtained by the reaction of 2,4,6-trichloro-1,3,5-triazine 1 with 3-(5-sulfanyl-1,3,4-oxadiazol-2-yl)-2H-chromen-2-one 2 which was obtained by following the method reported in the literature. Intermediate 3 was then condensed with 8-hydroxyquinoline 4 to form 3-(5-{[4-chloro-6-(quinolin-4-yloxy)-1,3,5-triazin-2-yl]sulfanyl}-1,3,4-oxadiazol-2-yl)-2H-chromen-2-one 5. This was further treated with various substituted piperazines and piperidines to obtain the title compounds 7a–u, which were then subjected to determine their in vitro biological efficacy against bacterial and fungal strains as two Gram-positive bacteria (S. aureus, B. cereus), six Gram-negative bacteria (E. coli, P. aeruginosa, K. pneumoniae, S. typhi, P. vulgaris, and S. flexneria) and two fungal species (A. niger, and C. albicans) with an intent to develop novel class of antimicrobial agents. The results indicate that some of the novel s-triazines have noteworthy activity in MIC (μg/ml) and zone of inhibition (mm) indicating potential leads for further drug discovery study. All the final compounds were structurally elucidated on the basis of IR, 1H NMR, 13C NMR, 19F NMR spectroscopy, and elemental analysis.

17 citations

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TL;DR: In this article, the anion recognition ability of a novel azo dye derived from 4-hydroxycuomarin (L) was investigated by experimental (UV-vis, fluorescence and 1H NMR) and theoretical (B3LYP/6-31G(d,p)] methods).

15 citations


Cited by
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Journal ArticleDOI
TL;DR: This work systematically gives a comprehensive review in current developments of BTA-based compounds in the whole range of medicinal chemistry as anticancer, antibacterial, antifungal, antiinflammatory, analgesic, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial and other medicinal agents.

337 citations

Journal ArticleDOI
TL;DR: Recent developments in the eco-friendly and green procedures for the construction of highly challenging and potentially bioactive quinazoline and quinzolinone compounds are recapitulate in order to help medicinal chemists in designing and synthesizing novel and potent compounds for the treatment of different disorders.

281 citations

Journal ArticleDOI
TL;DR: This review provides readers with an overview of the main synthetic methodologies for 1,3,4-oxadiazole derivatives, and of their broad spectrum of pharmacological activities as reported over the past twelve years.
Abstract: This review provides readers with an overview of the main synthetic methodologies for 1,3,4-oxadiazole derivatives, and of their broad spectrum of pharmacological activities as reported over the past twelve years.

190 citations

Journal ArticleDOI
TL;DR: The review here highlights the therapeutic significance of piperazine derivatives, which have made them indispensable anchors for the development of novel therapeutic agents.

138 citations

Journal ArticleDOI
TL;DR: The synthesis of a series of push-pull arylvinyl (styryl), aryl, and arylethynyl quinazoline derivatives by means of different straightforward protocols is reported, and the photophysical properties of the compounds are described.
Abstract: The synthesis of a series of push–pull arylvinyl (styryl), aryl, and arylethynyl quinazoline derivatives by means of different straightforward protocols is reported. The photophysical properties of the compounds are described. The preparation of arylvinylquinazolines was performed by aldol condensation of the appropriate methylquinazoline and functionalized benzaldehyde. Suzuki and Sonogashira cross-coupling reactions were used to prepare the aryl and arylethynyl compounds, respectively, starting from chloroquinazolines. Optical studies revealed that all of the compounds reported here behave in a way similar to that of their pyrimidine counterparts, with absorption bands in the UV or visible region and the emission of green light upon irradiation. Large red shifts were observed in the fluorescence emission maxima upon increasing the solvent polarity. This strong emission solvatochromism suggests the formation of an intramolecular charge-separated emitting state. The materials can be easily and reversibly ...

99 citations