Amit Gupta

Bio: Amit Gupta is an academic researcher from Sanjay Gandhi Post Graduate Institute of Medical Sciences. The author has contributed to research in topics: Medicine & Peritoneal dialysis. The author has an hindex of 42, co-authored 226 publications receiving 7973 citations. Previous affiliations of Amit Gupta include Stanford University & Northwestern University.

Peritoneal dialysis-related infections recommendations: 2010 update

Abstract: Department of Medicine and Therapeutics,1 Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong; University of Pittsburgh School of Medicine,2 Pittsburgh, PA, USA; Faculdade de Enfermagem, Nutrição e Fisioterapia,3 Pontifícia Universidade Católica do Rio Grande do Sul, Brazil; Sanjay Gandhi Postgraduate Institute of Medical Sciences,4 Lucknow, India; Department of Nephrology,5 Princess Alexandra Hospital, and School of Medicine, University of Queensland, Brisbane, Australia; Department of Medical Microbiology,6 Leiden University Medical Center, Leiden, The Netherlands; Centre for Kidney Diseases,7 Mount Elizabeth Medical Centre, Singapore; Section of Infectious Disease,8 Department of Internal Medicine, University of Missouri-Columbia School of Medicine, Columbia, MO, USA; Pediatric Nephrology Division,9 University Children’s Hospital, Heidelberg, Germany; Dianet Dialysis Centers,10 Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Peritoneal dialysis-related infections recommendations: 2005 update

Abstract: Peritonitis remains a leading complication of peritoneal dialysis (PD). It contributes to technique failure and hospitalization, and sometimes is associated with death of the patient. Severe and prolonged peritonitis can lead to peritoneal membrane failure. Therefore, the PD community continues to focus attention on prevention and treatment of PD-related infections.

Single virus particle mass detection using microresonators with nanoscale thickness

Abstract: In this letter, we present the microfabrication and application of arrays of silicon cantilever beams as microresonator sensors with nanoscale thickness to detect the mass of individual virus particles. The dimensions of the fabricated cantilever beams were in the range of 4–5 μm in length, 1–2 μm in width and 20–30 nm in thickness. The virus particles we used in the study were vaccinia virus, which is a member of the Poxviridae family and forms the basis of the smallpox vaccine. The frequency spectra of the cantilever beams, due to thermal and ambient noise, were measured using a laser Doppler vibrometer under ambient conditions. The change in resonant frequency as a function of the virus particle mass binding on the cantilever beam surface forms the basis of the detection scheme. We have demonstrated the detection of a single vaccinia virus particle with an average mass of 9.5 fg. These devices can be very useful as components of biosensors for the detection of airborne virus particles.

Object-oriented Programming Paradigms for Molecular Modeling

Abstract: This paper discusses the application of object-oriented programming (OOP) design concepts to the development of molecular simulation code. A number of new languages such as Fortran 90 (F90) have been developed over the last decade that support the OOP design philosophy. We briefly describe the salient features of F90 and some basic object-oriented design principles. As an illustration of the design concepts we implement a general interface in F90 for calculating pairwise interactions that can be extended easily to any number of different forcefield models. The ideas presented here are used in the development of a mu ltipurpose si mulation c ode, named Music. An example of the use of Music for grand canonical Monte Carlo (GCMC) simulations of flexible sorbate molecules in zeolites is given. The example illustrates how OOP allowed existing code for molecular dynamics and GCMC to be easily combined to perform hybrid GCMC simulations with minimal coding effort.

What do we know about chronic kidney disease in India: first report of the Indian CKD registry.

Abstract: There are no national data on the magnitude and pattern of chronic kidney disease (CKD) in India. The Indian CKD Registry documents the demographics, etiological spectrum, practice patterns, variations and special characteristics. Data was collected for this cross-sectional study in a standardized format according to predetermined criteria. Of the 52,273 adult patients, 35.5%, 27.9%, 25.6% and 11% patients came from South, North, West and East zones respectively. The mean age was 50.1 ± 14.6 years, with M:F ratio of 70:30. Patients from North Zone were younger and those from the East Zone older. Diabetic nephropathy was the commonest cause (31%), followed by CKD of undetermined etiology (16%), chronic glomerulonephritis (14%) and hypertensive nephrosclerosis (13%). About 48% cases presented in Stage V; they were younger than those in Stages III-IV. Diabetic nephropathy patients were older, more likely to present in earlier stages of CKD and had a higher frequency of males; whereas those with CKD of unexplained etiology were younger, had more females and more frequently presented in Stage V. Patients in lower income groups had more advanced CKD at presentation. Patients presenting to public sector hospitals were poorer, younger, and more frequently had CKD of unknown etiology. This report confirms the emergence of diabetic nephropathy as the pre-eminent cause in India. Patients with CKD of unknown etiology are younger, poorer and more likely to present with advanced CKD. There were some geographic variations.

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

Emerging applications of stimuli-responsive polymer materials

Abstract: Responsive polymer materials can adapt to surrounding environments, regulate transport of ions and molecules, change wettability and adhesion of different species on external stimuli, or convert chemical and biochemical signals into optical, electrical, thermal and mechanical signals, and vice versa. These materials are playing an increasingly important part in a diverse range of applications, such as drug delivery, diagnostics, tissue engineering and 'smart' optical systems, as well as biosensors, microelectromechanical systems, coatings and textiles. We review recent advances and challenges in the developments towards applications of stimuli-responsive polymeric materials that are self-assembled from nanostructured building blocks. We also provide a critical outline of emerging developments.

Nanostructures in Biodiagnostics

Abstract: In the last 10 years the field of molecular diagnostics has witnessed an explosion of interest in the use of nanomaterials in assays for gases, metal ions, and DNA and protein markers for many diseases. Intense research has been fueled by the need for practical, robust, and highly sensitive and selective detection agents that can address the deficiencies of conventional technologies. Chemists are playing an important role in designing and fabricating new materials for application in diagnostic assays. In certain cases assays based upon nanomaterials have offered significant advantages over conventional diagnostic systems with regard to assay sensitivity, selectivity, and practicality. Some of these new methods have recently been reviewed elsewhere with a focus on the materials themselves or as subclassifications in more generalized overviews of biological applications of nanomaterials.1-7 We intend to review some of the major advances and milestones in the field of detection systems based upon nanomaterials and their roles in biodiagnostic screening for nucleic acids, * To whom correspondence should be addressed. Phone: 847-4913907. Fax: 847-467-5123. E-mail: chadnano@northwestern.edu. Nathaniel L. Rosi earned his B.A. degree at Grinnell College (1999) and his Ph.D. degree from the University of Michigan (2003), where he studied the design, synthesis, and gas storage applications of metal−organic frameworks under the guidance of Professor Omar M. Yaghi. In 2003 he began postdoctoral studies as a member of Professor Mirkin’s group at Northwestern University. His current research focuses on the rational assembly of DNA-modified nanostructures into larger-scale materials.

Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology†

Abstract: Hydrophilic polymers are the center of research emphasis in nanotechnology because of their perceived “intelligence”. They can be used as thin films, scaffolds, or nanoparticles in a wide range of biomedical and biological applications. Here we highlight recent developments in engineering uncrosslinked and crosslinked hydrophilic polymers for these applications. Natural, biohybrid, and synthetic hydrophilic polymers and hydrogels are analyzed and their thermodynamic responses are discussed. In addition, examples of the use of hydrogels for various therapeutic applications are given. We show how such systems’ intelligent behavior can be used in sensors, microarrays, and imaging. Finally, we outline challenges for the future in integrating hydrogels into biomedical applications.

Principles and Practices of Interconnection Networks

Abstract: One of the greatest challenges faced by designers of digital systems is optimizing the communication and interconnection between system components. Interconnection networks offer an attractive and economical solution to this communication crisis and are fast becoming pervasive in digital systems. Current trends suggest that this communication bottleneck will be even more problematic when designing future generations of machines. Consequently, the anatomy of an interconnection network router and science of interconnection network design will only grow in importance in the coming years. This book offers a detailed and comprehensive presentation of the basic principles of interconnection network design, clearly illustrating them with numerous examples, chapter exercises, and case studies. It incorporates hardware-level descriptions of concepts, allowing a designer to see all the steps of the process from abstract design to concrete implementation. ·Case studies throughout the book draw on extensive author experience in designing interconnection networks over a period of more than twenty years, providing real world examples of what works, and what doesn't. ·Tightly couples concepts with implementation costs to facilitate a deeper understanding of the tradeoffs in the design of a practical network. ·A set of examples and exercises in every chapter help the reader to fully understand all the implications of every design decision. Table of Contents Chapter 1 Introduction to Interconnection Networks 1.1 Three Questions About Interconnection Networks 1.2 Uses of Interconnection Networks 1.3 Network Basics 1.4 History 1.5 Organization of this Book Chapter 2 A Simple Interconnection Network 2.1 Network Specifications and Constraints 2.2 Topology 2.3 Routing 2.4 Flow Control 2.5 Router Design 2.6 Performance Analysis 2.7 Exercises Chapter 3 Topology Basics 3.1 Nomenclature 3.2 Traffic Patterns 3.3 Performance 3.4 Packaging Cost 3.5 Case Study: The SGI Origin 2000 3.6 Bibliographic Notes 3.7 Exercises Chapter 4 Butterfly Networks 4.1 The Structure of Butterfly Networks 4.2 Isomorphic Butterflies 4.3 Performance and Packaging Cost 4.4 Path Diversity and Extra Stages 4.5 Case Study: The BBN Butterfly 4.6 Bibliographic Notes 4.7 Exercises Chapter 5 Torus Networks 5.1 The Structure of Torus Networks 5.2 Performance 5.3 Building Mesh and Torus Networks 5.4 Express Cubes 5.5 Case Study: The MIT J-Machine 5.6 Bibliographic Notes 5.7 Exercises Chapter 6 Non-Blocking Networks 6.1 Non-Blocking vs. Non-Interfering Networks 6.2 Crossbar Networks 6.3 Clos Networks 6.4 Benes Networks 6.5 Sorting Networks 6.6 Case Study: The Velio VC2002 (Zeus) Grooming Switch 6.7 Bibliographic Notes 6.8 Exercises Chapter 7 Slicing and Dicing 7.1 Concentrators and Distributors 7.2 Slicing and Dicing 7.3 Slicing Multistage Networks 7.4 Case Study: Bit Slicing in the Tiny Tera 7.5 Bibliographic Notes 7.6 Exercises Chapter 8 Routing Basics 8.1 A Routing Example 8.2 Taxonomy of Routing Algorithms 8.3 The Routing Relation 8.4 Deterministic Routing 8.5 Case Study: Dimension-Order Routing in the Cray T3D 8.6 Bibliographic Notes 8.7 Exercises Chapter 9 Oblivious Routing 9.1 Valiant's Randomized Routing Algorithm 9.2 Minimal Oblivious Routing 9.3 Load-Balanced Oblivious Routing 9.4 Analysis of Oblivious Routing 9.5 Case Study: Oblivious Routing in the Avici Terabit Switch Router(TSR) 9.6 Bibliographic Notes 9.7 Exercises Chapter 10 Adaptive Routing 10.1 Adaptive Routing Basics 10.2 Minimal Adaptive Routing 10.3 Fully Adaptive Routing 10.4 Load-Balanced Adaptive Routing 10.5 Search-Based Routing 10.6 Case Study: Adaptive Routing in the Thinking Machines CM-5 10.7 Bibliographic Notes 10.8 Exercises Chapter 11 Routing Mechanics 11.1 Table-Based Routing 11.2 Algorithmic Routing 11.3 Case Study: Oblivious Source Routing in the IBM Vulcan Network 11.4 Bibliographic Notes 11.5 Exercises Chapter 12 Flow Control Basics 12.1 Resources and Allocation Units 12.2 Bufferless Flow Control 12.3 Circuit Switching 12.4 Bibliographic Notes 12.5 Exercises Chapter 13 Buffered Flow Control 13.1 Packet-Buffer Flow Control 13.2 Flit-Buffer Flow Control 13.3 Buffer Management and Backpressure 13.4 Flit-Reservation Flow Control 13.5 Bibliographic Notes 13.6 Exercises Chapter 14 Deadlock and Livelock 14.1 Deadlock 14.2 Deadlock Avoidance 14.3 Adaptive Routing 14.4 Deadlock Recovery 14.5 Livelock 14.6 Case Study: Deadlock Avoidance in the Cray T3E 14.7 Bibliographic Notes 14.8 Exercises Chapter 15 Quality of Service 15.1 Service Classes and Service Contracts 15.2 Burstiness and Network Delays 15.3 Implementation of Guaranteed Services 15.4 Implementation of Best-Effort Services 15.5 Separation of Resources 15.6 Case Study: ATM Service Classes 15.7 Case Study: Virtual Networks in the Avici TSR 15.8 Bibliographic Notes 15.9 Exercises Chapter 16 Router Architecture 16.1 Basic Router Architecture 16.2 Stalls 16.3 Closing the Loop with Credits 16.4 Reallocating a Channel 16.5 Speculation and Lookahead 16.6 Flit and Credit Encoding 16.7 Case Study: The Alpha 21364 Router 16.8 Bibliographic Notes 16.9 Exercises Chapter 17 Router Datapath Components 17.1 Input Buffer Organization 17.2 Switches 17.3 Output Organization 17.4 Case Study: The Datapath of the IBM Colony Router 17.5 Bibliographic Notes 17.6 Exercises Chapter 18 Arbitration 18.1 Arbitration Timing 18.2 Fairness 18.3 Fixed Priority Arbiter 18.4 Variable Priority Iterative Arbiters 18.5 Matrix Arbiter 18.6 Queuing Arbiter 18.7 Exercises Chapter 19 Allocation 19.1 Representations 19.2 Exact Algorithms 19.3 Separable Allocators 19.4 Wavefront Allocator 19.5 Incremental vs. Batch Allocation 19.6 Multistage Allocation 19.7 Performance of Allocators 19.8 Case Study: The Tiny Tera Allocator 19.9 Bibliographic Notes 19.10 Exercises Chapter 20 Network Interfaces 20.1 Processor-Network Interface 20.2 Shared-Memory Interface 20.3 Line-Fabric Interface 20.4 Case Study: The MIT M-Machine Network Interface 20.5 Bibliographic Notes 20.6 Exercises Chapter 21 Error Control 411 21.1 Know Thy Enemy: Failure Modes and Fault Models 21.2 The Error Control Process: Detection, Containment, and Recovery 21.3 Link Level Error Control 21.4 Router Error Control 21.5 Network-Level Error Control 21.6 End-to-end Error Control 21.7 Bibliographic Notes 21.8 Exercises Chapter 22 Buses 22.1 Bus Basics 22.2 Bus Arbitration 22.3 High Performance Bus Protocol 22.4 From Buses to Networks 22.5 Case Study: The PCI Bus 22.6 Bibliographic Notes 22.7 Exercises Chapter 23 Performance Analysis 23.1 Measures of Interconnection Network Performance 23.2 Analysis 23.3 Validation 23.4 Case Study: Efficiency and Loss in the BBN Monarch Network 23.5 Bibliographic Notes 23.6 Exercises Chapter 24 Simulation 24.1 Levels of Detail 24.2 Network Workloads 24.3 Simulation Measurements 24.4 Simulator Design 24.5 Bibliographic Notes 24.6 Exercises Chapter 25 Simulation Examples 495 25.1 Routing 25.2 Flow Control Performance 25.3 Fault Tolerance Appendix A Nomenclature Appendix B Glossary Appendix C Network Simulator