Amit Gupta

Bio: Amit Gupta is an academic researcher from Indian Institute of Technology Delhi. The author has contributed to research in topics: Lattice Boltzmann methods & Reynolds number. The author has an hindex of 23, co-authored 105 publications receiving 1761 citations. Previous affiliations of Amit Gupta include Indian Institutes of Technology & University of Michigan.

Effect of geometry on droplet formation in the squeezing regime in a microfluidic T-junction

Abstract: In the surface tension-dominated microchannel T-junction, droplets can be formed as a result of the mixing of two dissimilar, immiscible fluids. This article presents results for very low Capillary numbers and different flow rates of the continuous and dispersed phases. Through three-dimensional lattice Boltzmann-based simulations, the mechanism of the formation of “plugs” in the squeezing regime has been examined and the size of the droplets quantified. Results for $$ Re_{\text{c}} \ll 1$$ show the dependence of flow rates of the two fluids on the length of the droplets formed, which is compared with existing experimental data. It is shown that the size of plugs formed decreases as the Capillary number increases in the squeezing regime. This article clearly shows that the geometry effect, i.e., the widths of the two channels and the depth of the assembly, plays an important role in the determination of the length of the plugs, a fact that was ignored in earlier experimental correlations.

Droplet formation and stability of flows in a microfluidic T-junction

Abstract: Flow regimes obtained as a consequence of two immiscible fluids interacting at a T-junction are presented for high Capillary numbers and different flow rates of the continuous and dispersed phases. Through lattice Boltzmann based simulations, a regime map is created that distinguishes parallel flows from droplet flows. Simulations show the dependence of flow rates and viscosity ratio on the volume of droplets formed, which is compared with existing experimental data. At high Capillary numbers, the transition zone which separates parallel and droplet flows shrinks, and is influenced by the viscosity ratio as well.

Flow regime transition at high capillary numbers in a microfluidic T-junction: Viscosity contrast and geometry effect

Abstract: Flow regimes obtained as a consequence of two immiscible fluids interacting at a T-junction are presented for transitional to high capillary numbers and different ratios of the continuous and dispersed phase flow rates and viscosities. Results are presented for the formation of micron-sized droplets using simulations performed based on a three-dimensional lattice Boltzmann method. The influence of viscosity and geometry of the device on the frequency and volume of droplets formed has been examined and the nondimensional drop size correlated with the capillary number and flow rate ratio. This work reveals two important and new physical features: (a) the transition zone separating droplet and jet flows narrows for high capillary numbers and (b) the critical flow rate ratio separating droplet and parallel flows increases as the dispersed to continuous channel width ratio increases, aspects which have been correlated using a simple relation for both transitions from the droplet-at-T-junction to droplet-in-cha...

The C programming language

Abstract: This ebook is the first authorized digital version of Kernighan and Ritchie's 1988 classic, The C Programming Language (2nd Ed.). One of the best-selling programming books published in the last fifty years, "K&R" has been called everything from the "bible" to "a landmark in computer science" and it has influenced generations of programmers. Available now for all leading ebook platforms, this concise and beautifully written text is a "must-have" reference for every serious programmers digital library. As modestly described by the authors in the Preface to the First Edition, this "is not an introductory programming manual; it assumes some familiarity with basic programming concepts like variables, assignment statements, loops, and functions. Nonetheless, a novice programmer should be able to read along and pick up the language, although access to a more knowledgeable colleague will help."

Droplet based microfluidics

Abstract: Droplet based microfluidics is a rapidly growing interdisciplinary field of research combining soft matter physics, biochemistry and microsystems engineering. Its applications range from fast analytical systems or the synthesis of advanced materials to protein crystallization and biological assays for living cells. Precise control of droplet volumes and reliable manipulation of individual droplets such as coalescence, mixing of their contents, and sorting in combination with fast analysis tools allow us to perform chemical reactions inside the droplets under defined conditions. In this paper, we will review available drop generation and manipulation techniques. The main focus of this review is not to be comprehensive and explain all techniques in great detail but to identify and shed light on similarities and underlying physical principles. Since geometry and wetting properties of the microfluidic channels are crucial factors for droplet generation, we also briefly describe typical device fabrication methods in droplet based microfluidics. Examples of applications and reaction schemes which rely on the discussed manipulation techniques are also presented, such as the fabrication of special materials and biophysical experiments.

Passive and active droplet generation with microfluidics: a review

Abstract: Precise and effective control of droplet generation is critical for applications of droplet microfluidics ranging from materials synthesis to lab-on-a-chip systems. Methods for droplet generation can be either passive or active, where the former generates droplets without external actuation, and the latter makes use of additional energy input in promoting interfacial instabilities for droplet generation. A unified physical understanding of both passive and active droplet generation is beneficial for effectively developing new techniques meeting various demands arising from applications. Our review of passive approaches focuses on the characteristics and mechanisms of breakup modes of droplet generation occurring in microfluidic cross-flow, co-flow, flow-focusing, and step emulsification configurations. The review of active approaches covers the state-of-the-art techniques employing either external forces from electrical, magnetic and centrifugal fields or methods of modifying intrinsic properties of flows or fluids such as velocity, viscosity, interfacial tension, channel wettability, and fluid density, with a focus on their implementations and actuation mechanisms. Also included in this review is the contrast among different approaches of either passive or active nature.