A
Amit Sharma
Researcher at University Hospital Bonn
Publications - 50
Citations - 560
Amit Sharma is an academic researcher from University Hospital Bonn. The author has contributed to research in topics: DNA methylation & Gene. The author has an hindex of 11, co-authored 44 publications receiving 335 citations. Previous affiliations of Amit Sharma include University of Bonn.
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Journal ArticleDOI
DNA methylation signature in peripheral blood reveals distinct characteristics of human X chromosome numerical aberrations
Amit Sharma,Muhammad Jamil,Nicole Nuesgen,Felix Schreiner,Lutz Priebe,Per Hoffmann,Stefan Herns,Markus M. Nöthen,Holger Fröhlich,Johannes Oldenburg,Joachim Woelfle,Osman El-Maarri +11 more
TL;DR: DNA methylation changes were widespread on all autosomal chromosomes in 45,X and in 47,XXY individuals, with Turner individuals presenting five times more affected loci, which suggests a certain stochastic/random contribution to the methylationChanges at each locus.
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Advanced glycation end products and protein carbonyl levels in plasma reveal sex-specific differences in Parkinson's and Alzheimer's disease.
Amit Sharma,Daniela Weber,Jana Raupbach,Tikam Chand Dakal,Klaus Fließbach,Alfredo Ramirez,Tilman Grune,Ullrich Wüllner +7 more
TL;DR: Sex-specific differences were observed for AGEs, markers of oxidative stress and micronutrients in the plasma of PD and AD patients and controls, suggesting to make a clear distinction between sexes when analyzing oxidative (AGEs)-related stress and carbonyl- related stress and vitamins.
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Inter-locus as well as intra-locus heterogeneity in LINE-1 promoter methylation in common human cancers suggests selective demethylation pressure at specific CpGs
Nicole Nüsgen,Wolfgang Goering,Albertas Daukša,Arijit Biswas,Muhammad Jamil,Ioanna M. Dimitriou,Amit Sharma,Heike Singer,Rolf Fimmers,Holger Fröhlich,Johannes Oldenburg,Antanas Gulbinas,Wolfgang A. Schulz,Osman El-Maarri +13 more
TL;DR: Methylation changes at individual LINE-1 loci are heterogeneous, whereas specific CpGs within the consensus sequence appear to be more prone to hypomethylation, which could lead to a broader selection of loci for tumor detection.
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Genetic and epigenetic insights into uveal melanoma.
Amit Sharma,Marta M. Stei,Holger Fröhlich,Frank G. Holz,Karin U. Loeffler,Martina C. Herwig-Carl +5 more
TL;DR: A review of the literature with emphasis on genetic alterations, epigenetic modifications and signaling pathways as well as possible biomarkers in UM and different research models for UM is discussed.
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Mechanistic basis of co-stimulatory CD40-CD40L ligation mediated regulation of immune responses in cancer and autoimmune disorders
Tikam Chand Dakal,Bhanupriya Dhabhai,Disha Agarwal,Ritisha Gupta,Girima Nagda,Asha Ram Meena,Ramgopal Dhakar,Athira M. Menon,Riya Mathur,Mona,Vinod Yadav,Amit Sharma +11 more
TL;DR: The current paradigm is to target CD40 using agonist anti-CD40 mAbs alone or in synergistic combination with chemotherapy in order to harness or confer anti-tumor and anti-inflammatory immunity.