抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.

Pattern Recognition and Machine Learning

The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors. While the organization of the book is similar to previous editions, major emphasis has been placed on disorders that affect multiple organ systems. Important advances in genetics, immunology, and oncology are emphasized. Many chapters of the book have been rewritten and describe major advances in internal medicine. Subjects that received only a paragraph or two of attention in previous editions are now covered in entire chapters. Among the chapters that have been extensively revised are the chapters on infections in the compromised host, on skin rashes in infections, on many of the viral infections, including cytomegalovirus and Epstein-Barr virus, on sexually transmitted diseases, on diabetes mellitus, on disorders of bone and mineral metabolism, and on lymphadenopathy and splenomegaly. The major revisions in these chapters and many

Harrison's Principles of Internal Medicine

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

Nanocrystals are fundamental to modern science and technology. Mastery over the shape of a nanocrystal enables control of its properties and enhancement of its usefulness for a given application. Our aim is to present a comprehensive review of current research activities that center on the shape-controlled synthesis of metal nanocrystals. We begin with a brief introduction to nucleation and growth within the context of metal nanocrystal synthesis, followed by a discussion of the possible shapes that a metal nanocrystal might take under different conditions. We then focus on a variety of experimental parameters that have been explored to manipulate the nucleation and growth of metal nanocrystals in solution-phase syntheses in an effort to generate specific shapes. We then elaborate on these approaches by selecting examples in which there is already reasonable understanding for the observed shape control or at least the protocols have proven to be reproducible and controllable. Finally, we highlight a number of applications that have been enabled and/or enhanced by the shape-controlled synthesis of metal nanocrystals. We conclude this article with personal perspectives on the directions toward which future research in this field might take.

Shape‐Controlled Synthesis of Metal Nanocrystals: Simple Chemistry Meets Complex Physics?

Leptin protein is synthesized by adipose tissue and is involved in regulation of milk yield. We investigated the association of genetic polymorphism in the bovine leptin gene with 305 days milk yield for the first 3 lactations. The study was conducted on 209 lactating Karan Fries cattle with known pedigree belonging to 3 genetic groups at an organized herd. All the cattle were genotyped by PCR-RFLP assay, and 3 genotypes, viz. TT, TC and CC were identified in the exon-2 region of leptin gene. Representative PCR products of the genotyped animals were sequenced across the polymorphism. Karan Fries cattle with TT genotype showed significantly higher 305 days milk yield as compared to cattle with CC genotype.

Association of leptin gene polymorphism with 305 days milk

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SAR Analysis of Hexagonal-shaped Slot Loaded Patch Antenna for Hyperthermia Application at 434 MHz

The phosphorus removal potential of the bloom‐forming, alkali‐tolerant cyanobacterium Oscillatoria amphibia was studied by entrapping and immobilizing it in calcium alginate. The uptake kinetics for orthophosphate‐phosphorus (PO4‐P) were determined by growing O. amphibia in Jaworski medium (pH 9) in 14.6 Wm‐2 light intensity at 24±1°C. The pH of the culture medium increased to 11.0 during growth. This facilitated the maintenance of unialgal cultures in the absence of any contaminants. Immobilized filaments showed potential capability of phosphorus accumulation. A stocking biomass of 0.4 μg chl a bead‐1 at external pH 9 was found to be suitable for rapid phosphorus removal. Phosphorus uptake kinetics of immobilized filaments were also dependent on the initial phosphorus concentration. These findings may be useful for designing a bioreactor to optimize phosphorus removal using an immobilized cyanobacterial system.

Amit Singh

Papers

Association of leptin gene polymorphism with 305 days milk

SAR Analysis of Hexagonal-shaped Slot Loaded Patch Antenna for Hyperthermia Application at 434 MHz

Phosphorus uptake by immobilized cells of the alkali‐tolerant cyanobacterium oscillatoria amphibia ag. ex gomont

Effect of purified seminal plasma heparin binding proteins on in vitro acrosome reaction of frozen-thawed buffalo bull semen.

Phylogenetic characterization and analysis of Sarcocystis buffalonis.