Amit Singh

Bio: Amit Singh is an academic researcher from National Institute of Technology, Patna. The author has contributed to research in topics: Digital watermarking & Watermark. The author has an hindex of 57, co-authored 640 publications receiving 13795 citations. Previous affiliations of Amit Singh include Ithaca College & Center for Infectious Disease Research and Policy.

Structural variability of Mycobacterium tuberculosis SSB and susceptibility to inhibition

Abstract: Srikalaivani Raja, Anju Paul, Sriram Raghavan, Sibi Narayanan, Somnath Shee, Amit Singh, Umesh Varshney, Balasubramanian Gopal and Mamannamana Vijayan* Molecular Biophysics Unit, Indian Institute of Science, Bengaluru 560 012, India Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560 012, India Centre for Infectious Disease Research, Indian Institute of Science, Bengaluru 560 012, India Present address: RIKEN Center for Computational Science, Japan Present address: Sitaram Ayurveda Private Limited, Thrissur 680 007, India

Targeted Delivery of Antibiotics Using Microparticles to Combat Multidrug-Resistant Tuberculosis

Abstract: Tuberculosis (TB) continues to be a major global challenge, claiming about two million deaths each year. The emergence of drug resistance due to high incidence of poor patient compliance has further worsened the situation. Targeted delivery of drugs to macrophage, the site of Mycobacterium tuberculosis infection and replication, has been shown to have implications as a promising option in TB treatment. A variety of biocompatible and biodegradable polymer-based carrier-based delivery systems have emerged as potential drug delivery systems (DDS). Such targeted delivery systems have been shown to have significant merits over free drug, including improved drug bioavailability, limiting adverse drug effects and requiring less frequent administration regimes and lowering drug doses. The pulmonary administration of inhalable dry powders incorporating multiple drugs has particularly exhibited encouraging results against MDR-TB, and is expected to shorten the treatment duration, thereby improving patient compliance. Recently, the administration of pulmonary drug delivery as an adjunct to existing oral treatment regimens has been shown to achieve sufficient drug concentrations in certain systemic compartments and thus further enhance treatment effectiveness. The present chapter discusses the recent research updates on carriers used in preclinical or clinical studies against TB, the challenges associated, and future perspectives.

A Meandered Inductive Loop based RFID Tag Antenna at 866 MHz

Abstract: In this article, a regular tag antenna supporting UHF band RFID composed of spiral-ending meander-line with meandered inductive loop is depicted. This portrayed novel compact spiral-ending meandered tag with dual sided meandered inductive loop microstrip dipole cuts down the area of tag antenna plus provides an upgraded conjugate impedance-matching amid tag and semiconductor ASIC. Aforementioned tag antenna serves at 866 MHz. A predominating compact UHF tag confining the extents of $60\text{mm}\times 16\text{mm}\times 1.6\text{mm}(0.173\lambda\times 0.046\lambda\times 0.0046\lambda)$, retaining impressive reflection coefficient has been elegantly testified and it is competent to access recognition territory of 12.6 m. Presented tag antenna layout is simulated in favor of 4 W EIRP reader.

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

Pattern Recognition and Machine Learning

Abstract: Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.

Harrison's Principles of Internal Medicine

Abstract: The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors. While the organization of the book is similar to previous editions, major emphasis has been placed on disorders that affect multiple organ systems. Important advances in genetics, immunology, and oncology are emphasized. Many chapters of the book have been rewritten and describe major advances in internal medicine. Subjects that received only a paragraph or two of attention in previous editions are now covered in entire chapters. Among the chapters that have been extensively revised are the chapters on infections in the compromised host, on skin rashes in infections, on many of the viral infections, including cytomegalovirus and Epstein-Barr virus, on sexually transmitted diseases, on diabetes mellitus, on disorders of bone and mineral metabolism, and on lymphadenopathy and splenomegaly. The major revisions in these chapters and many

Shape‐Controlled Synthesis of Metal Nanocrystals: Simple Chemistry Meets Complex Physics?

Abstract: Nanocrystals are fundamental to modern science and technology. Mastery over the shape of a nanocrystal enables control of its properties and enhancement of its usefulness for a given application. Our aim is to present a comprehensive review of current research activities that center on the shape-controlled synthesis of metal nanocrystals. We begin with a brief introduction to nucleation and growth within the context of metal nanocrystal synthesis, followed by a discussion of the possible shapes that a metal nanocrystal might take under different conditions. We then focus on a variety of experimental parameters that have been explored to manipulate the nucleation and growth of metal nanocrystals in solution-phase syntheses in an effort to generate specific shapes. We then elaborate on these approaches by selecting examples in which there is already reasonable understanding for the observed shape control or at least the protocols have proven to be reproducible and controllable. Finally, we highlight a number of applications that have been enabled and/or enhanced by the shape-controlled synthesis of metal nanocrystals. We conclude this article with personal perspectives on the directions toward which future research in this field might take.