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Amit Singh

Bio: Amit Singh is an academic researcher from National Institute of Technology, Patna. The author has contributed to research in topics: Digital watermarking & Watermark. The author has an hindex of 57, co-authored 640 publications receiving 13795 citations. Previous affiliations of Amit Singh include Ithaca College & Center for Infectious Disease Research and Policy.


Papers
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Journal Article
TL;DR: It can be concluded that caged broilers supplemented with Shatavari (Asparagus racemosus) and Ashwagandha root powder may perform well in caged conditions in terms of improved body weight and feed intake.
Abstract: Use of antibiotics has been found to have negative effects on broiler health and its production therefore; there is a need for supplementation of herbal ingredients in broiler feed. An experiment was conducted on herbal dietary supplementation of Shatavari (Asparagus racemosus) and Ashwagandha (Withania somnifera) root powder to study its effect on growth performance in caged broilers. A total of 48 Day old broiler chicks of same hatch were procured and randomly divided into four groups with three sub groups comprising of 3 chicks in each to serve as replicates T0 (control) had standard ration as per NRC; T1 ration was supplemented with 5g Shatavari root powder /kg feed; T2 ration was supplemented with 5g Ashwagandha powder /kg feed and T3 ration was supplemented with 2.5g Shatavari + 2.5g Ashwagandha powder/ kg feed. The birds were reared in battery type cages under standard management practices from day-old to five weeks of age. Statistically analyzed data shown that the average body weight was significantly (p< 0.05) highest in T3 group followed by T2, T0 and T1 group. Similar trend was seen in the case of feed intake where significantly higher (p< 0.05) feed intake was found in T3 group followed by T2, T0 and T1 group. From this study it can be concluded that caged broilers supplemented with 2.5g Shatavari + 2.5g Ashwagandha powder/ kg feed may perform well in caged conditions in terms of improved body weight and feed intake.

5 citations

Journal ArticleDOI
TL;DR: In this article, the authors presented an analysis of the volume expansion data for periclase (MgO), lime (CaO), corundum (Al2O3), spinel and spinel from 300K up to 3000K.
Abstract: We have presented an analysis of the volume expansion data for periclase (MgO), lime (CaO), corundum (Al2O3) and spinel (MgAl2O4) determined experimentally by Fiquet et al (1999) from 300K up to 3000K. The thermal equation of state due to Suzuki et al (1979) and Shanker et al (1997) are used to study the relationships between thermal pressure and volume expansion for the entire range of temperatures starting from room temperature up to the melting temperatures of the solids under study. Comparison of the results obtained in the present study with the corresponding experimental data reveal that the thermal pressure changes with temperature almost linearly up to quite high temperatures. At extremely high temperatures close to the melting temperatures thermal pressure deviates significantly from linearity. This prediction is consistent with other recent investigations. A quantitative analysis based on the theory of anharmonic effects has been presented to account for the nonlinear variation of the thermal pressure at high temperatures.

5 citations

01 Jan 2012
TL;DR: Results suggest that absence of hydroxyl group substitution at C3 increases the potency of flavonoid inhibitors for cytochrome b5 reductase.
Abstract: NADH-cytochrome b5 reductase, a flavoprotein, plays a central role in many diverse metabolic reactions. NADH-cytochrome b5 reductase has been shown to be responsible for the generation of free radicals from heterocyclic amines. Flavonoids compounds share remarkable similarity in structure but showed differences in their cytochrome b5 reductase inhibition pattern. Our molecular dynamics simulation studies revealed that the difference in substitution at C3 position of ring C may lead to difference in interaction with enzyme. Absence of hydroxyl group substitution at C3 in luteolin facilitates the strong cation-π interaction between Lys185 and ring A, and C and π-π between Phe92 and ring A, and C along with h-bonding between Lys185 and oxo group. Ring B of luteolin showed strong π-π interaction with FAD. These interactions were found absent in quercetin and taxifolin. These results suggest that absence of hydroxyl group substitution at C3 increases the potency of flavonoid inhibitors for cytochrome b5 reductase.

5 citations

Journal ArticleDOI
TL;DR: Preoperative comorbidities, operative techniques, and postoperative complications in this setting are associated with morbidity and mortality and proper screening on admission should be done to identify premorbid illness, and with the use of some recommendations in surgical technique the authors can achieve safe outcome of gastrointestinal perforations.
Abstract: Background: Perforation peritonitis is one of the most commonly encountered surgical emergencies across the world. In developing countries, gastrointestinal perforations have very high morbidity and mortality rates, irrespective of the type of operative procedure performed. The aim of the present study was to evaluate and find out various determinants for safe outcome in gastrointestinal perforation in terms of decreased morbidity and mortality and applying Clavien–Dindo classification for postoperative complications for evaluating the outcome. Patients and Methods: A nonrandomized retrospective study with collected data from 350 patients with gastrointestinal perforations was conducted over a period of 3 years. Data from various preoperative and operative factors, surgical technique, and complications were recorded. The output was measured as better and worse, as per the classification proposed by Clavien–Dindo. Results: The study enrolled 350 patients with a male:female ratio of 3.3:1; 58% of the patients were Conclusion: Preoperative comorbidities, operative techniques, and postoperative complications in this setting are associated with morbidity and mortality. Proper screening on admission should be done to identify premorbid illness, and with the use of some recommendations in surgical technique we can achieve safe outcome of gastrointestinal perforations. The Clavien–Dindo classification can be adapted to assess the severity of postoperative complications following gastrointestinal perforations.

5 citations

Journal ArticleDOI
TL;DR: It is demonstrated that a bio‐layer interferometry (BLI) chaperonin detection system can identify superior refolding conditions for denatured proteins and demonstrates conditions where accelerated folding can be observed for the aggregation‐prone protein maltodextrin glucosidase (MalZ).
Abstract: Protein folding has been extensively studied for the past six decades by employing solution-based methods such as solubility, enzymatic activity, secondary structure analysis, and analytical methods like FRET, NMR, and HD exchange. However, for rapid analysis of the folding process, solution-based approaches are often plagued with aggregation side reactions resulting in poor yields. In this work, we demonstrate that a bio-layer interferometry (BLI) chaperonin detection system can identify superior refolding conditions for denatured proteins. The degree of immobilized protein folding as a function of time can be detected by monitoring the binding of the high-affinity nucleotide-free form of the chaperonin GroEL. GroEL preferentially interacts with proteins that have hydrophobic surfaces exposed in their unfolded or partially folded form, so a decrease in GroEL binding can be correlated with burial of hydrophobic surfaces as folding progresses. The magnitude of GroEL binding to the protein immobilized on bio-layer interferometry biosensor inversely reflects the extent of protein folding and hydrophobic residue burial. We demonstrate conditions where accelerated folding can be observed for the aggregation-prone protein maltodextrin glucosidase (MalZ). Superior immobilized folding conditions identified on the bio-layer interferometry biosensor surface were reproduced on Ni-NTA sepharose bead surfaces and resulted in significant improvement in folding yields of released MalZ (measured by enzymatic activity) compared to bulk refolding conditions in solution.

5 citations


Cited by
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28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

18,940 citations

Christopher M. Bishop1
01 Jan 2006
TL;DR: Probability distributions of linear models for regression and classification are given in this article, along with a discussion of combining models and combining models in the context of machine learning and classification.
Abstract: Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.

10,141 citations

Journal ArticleDOI
TL;DR: The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors.
Abstract: The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors. While the organization of the book is similar to previous editions, major emphasis has been placed on disorders that affect multiple organ systems. Important advances in genetics, immunology, and oncology are emphasized. Many chapters of the book have been rewritten and describe major advances in internal medicine. Subjects that received only a paragraph or two of attention in previous editions are now covered in entire chapters. Among the chapters that have been extensively revised are the chapters on infections in the compromised host, on skin rashes in infections, on many of the viral infections, including cytomegalovirus and Epstein-Barr virus, on sexually transmitted diseases, on diabetes mellitus, on disorders of bone and mineral metabolism, and on lymphadenopathy and splenomegaly. The major revisions in these chapters and many

6,968 citations

Journal ArticleDOI
TL;DR: A comprehensive review of current research activities that center on the shape-controlled synthesis of metal nanocrystals, including a brief introduction to nucleation and growth within the context of metal Nanocrystal synthesis, followed by a discussion of the possible shapes that aMetal nanocrystal might take under different conditions.
Abstract: Nanocrystals are fundamental to modern science and technology. Mastery over the shape of a nanocrystal enables control of its properties and enhancement of its usefulness for a given application. Our aim is to present a comprehensive review of current research activities that center on the shape-controlled synthesis of metal nanocrystals. We begin with a brief introduction to nucleation and growth within the context of metal nanocrystal synthesis, followed by a discussion of the possible shapes that a metal nanocrystal might take under different conditions. We then focus on a variety of experimental parameters that have been explored to manipulate the nucleation and growth of metal nanocrystals in solution-phase syntheses in an effort to generate specific shapes. We then elaborate on these approaches by selecting examples in which there is already reasonable understanding for the observed shape control or at least the protocols have proven to be reproducible and controllable. Finally, we highlight a number of applications that have been enabled and/or enhanced by the shape-controlled synthesis of metal nanocrystals. We conclude this article with personal perspectives on the directions toward which future research in this field might take.

4,927 citations