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Amit Singh

Bio: Amit Singh is an academic researcher from National Institute of Technology, Patna. The author has contributed to research in topics: Digital watermarking & Watermark. The author has an hindex of 57, co-authored 640 publications receiving 13795 citations. Previous affiliations of Amit Singh include Ithaca College & Center for Infectious Disease Research and Policy.


Papers
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Journal ArticleDOI
TL;DR: It is demonstrated that simple pH titration and absorbance measurements can determine the coordination state of heme iron atom in ferric hemoglobins, thus providing unambiguous information about the classification of new globins.

3 citations

Journal ArticleDOI
TL;DR: In this paper, a case of perforation peritonitis in 25 year postpartum woman due to a bezoar in the jejunum was reported, the patient had history of eating threads from quilt in her pregnancy days.
Abstract: Dear Sir, We are reporting here a rare case of perforation peritonitis in 25 year postpartum woman due to a bezoar in the jejunum. Patient had history of eating threads from quilt in her pregnancy days. Exploratory laparotomy reviled atypical perforation at mesenteric border of jejunum with protrusion of threads. She was managed by removal of whole thread bezoar and standard primary repair of perforation [Table/Fig-1]. There were no concomitant bezoars in the stomach or duodenum and proximal jejunum ascertain intraoperatively by palpation and postoperative upper gastrointestinal endoscopic studies. In this article, we also discussed about possible aetiology of this case “abnormal eating behaviour in pregnancy” due to pica. [Table/Fig-1]: Shows atypical jejunal perforation at mesenteric end with protrusion of cotton threads. Bezoars are compact masses formed of various indigestible foreign or intrinsic substances found in the gastrointestinal tract. Bezoars are classified in subgroups according to composition: 1) Phytobezoar is a particular type of bezoar composed of indigestible cellulose, tannin & lignin derived from ingested vegetables & fruits; 2) Diospyrobezoar is type of phytobezoar formed from unripe persimmons; 3) Pharmacobezoar (composed of undigested medications); 4) Trichobezoar (composed of hair); 5) Lactobezoar (reported only in neonatal period & consisting of ingested milk). Causes of bezoar includes the presence of indigestible material in the lumen usually diagnosed in mentally retarded or psychiatric patients with gastric dysmotility (including previous surgery like vagotomy and partial gastrectomy etc.,) and poor mastication, vegetarian diet, diabetic gastroparesis, hypothyroidism [1]. In our case report, patient was suffering from abnormal eating behaviour in pregnancy due to pica. The aetiology of pica is complex which includes environmental, nutritional, socioeconomic, physiologic, cultural, and psychiatric factors. Theories concerning possible nutritional deficiencies as a cause of pica are abundant, with many researchers including vitamin and mineral deficiency in the list of suggested risk factors [2]. One of the theory behind increased hunger in the pregnancy is; during pregnancy women are resistant to “Leptin”, an endocrine growth factor which is responsible for reduces appetite and stimulates metabolism by interacting with receptors at the “appetite centre” of the hypothalamus [3]. Without Leptin, multiple hunger stimulating orexigenic pathways are left unopposed. This results in decreased immunoreactivity by one of the most potent orexigenic agent “Neuropeptide Y” [4]. During pregnancy 75% of women also have changes in sense perception in the form of “increased sensitivity to odours” and “a metallic taste in the mouth”. Certain items possess a strong sensory attraction for women who practice pica. There was a connection between liking the taste and enjoying its texture in the mouth [2,5]. Same occur in our case in which pregnant woman like taste of quilt threads and practiced pica throughout pregnancy. It was seen that whole bunch of cotton thread bezoar was retrieved [Table/Fig-2]. [Table/Fig-2]: Shows whole bunch of cotton thread bezoar. It has been hypothesized that these altered gustatory and olfactory perception thresholds are caused by a change of neuronal activity within the pregnant women brain due to adjacent uterine and gustatory neurons may be interacting with one another [6]. What made our case unique was the postpartum diagnosis of young female without a psychiatric history, practice pica, have small bowel cotton thread bezoar without parent stomach bezoar and atypical perforation at mesenteric end of jejunum which is very rare. Bezoars are a bizzare medical problem, though the incidence is low. It has been our effort to point out the psychological or other aetiological manifestation of bezoar, like our case one should aware about pica practice in pregnancy, which is often missed and undertreated, that may result in bezoar and perforation which is life threatening to patient and her child.

3 citations

Journal ArticleDOI
22 Oct 2021-iScience
TL;DR: In this paper, the authors used the Drosophila eye model to demonstrate the potential of 5 unique newt (Notophthalmus viridescens) gene(s), viropana1-viropana5 (vna1-vna5), which were ectopically expressed in L2 mutant and GMR-hid, GMR GAL4 eye.

3 citations

Journal ArticleDOI
25 Jan 2017
TL;DR: In this paper, the authors made an attempt to investigate financial integration between National Stock Exchange and ASX stock market taking daily closing index of ASX and NSE and found that NSE market provides slightly higher returns than ASX market.
Abstract: Growth of a country is dependent upon growth of industries which, in turn, depends upon capital market conditions because this market is going to give an element which is most important for the success and failure of every industry i.e., funds. The Australian Securities Exchange market is the largest exchange in the world with market capitalisation of more than A$ 1.5 trillion. It is the finest and most advanced and automated exchange of the world. India is also having sophisticated stock exchange which is National Stock Exchange. The present paper made an attempt to investigate financial integration between NSE and ASX stock market taking daily closing index of ASX and NSE. The descriptive statistics showed NSE market provides slightly higher returns than ASX market. The results of Granger causality show that ASX does not Granger cause return at NSE and NSE also does not Granger cause return at ASX. The Johansen Co-integration test also speaks about no co-integration between them. Therefore, during the study we did not find a strong financial integration between both the nations' stock market.

2 citations

Patent
01 Apr 2016
TL;DR: In this article, the preparation of a crystalline form of a idelalisib methyl-tert-butyl ether solvate (form M1) is described.
Abstract: The preparation of a crystalline form of a idelalisib methyl-tert-butyl ether solvate (form M1) is disclosed herein. Drying of this solvate form M1 at elelvated temparature leads to the idelalisib form M2.

2 citations


Cited by
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28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

18,940 citations

Christopher M. Bishop1
01 Jan 2006
TL;DR: Probability distributions of linear models for regression and classification are given in this article, along with a discussion of combining models and combining models in the context of machine learning and classification.
Abstract: Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.

10,141 citations

Journal ArticleDOI
TL;DR: The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors.
Abstract: The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors. While the organization of the book is similar to previous editions, major emphasis has been placed on disorders that affect multiple organ systems. Important advances in genetics, immunology, and oncology are emphasized. Many chapters of the book have been rewritten and describe major advances in internal medicine. Subjects that received only a paragraph or two of attention in previous editions are now covered in entire chapters. Among the chapters that have been extensively revised are the chapters on infections in the compromised host, on skin rashes in infections, on many of the viral infections, including cytomegalovirus and Epstein-Barr virus, on sexually transmitted diseases, on diabetes mellitus, on disorders of bone and mineral metabolism, and on lymphadenopathy and splenomegaly. The major revisions in these chapters and many

6,968 citations

Journal ArticleDOI
TL;DR: A comprehensive review of current research activities that center on the shape-controlled synthesis of metal nanocrystals, including a brief introduction to nucleation and growth within the context of metal Nanocrystal synthesis, followed by a discussion of the possible shapes that aMetal nanocrystal might take under different conditions.
Abstract: Nanocrystals are fundamental to modern science and technology. Mastery over the shape of a nanocrystal enables control of its properties and enhancement of its usefulness for a given application. Our aim is to present a comprehensive review of current research activities that center on the shape-controlled synthesis of metal nanocrystals. We begin with a brief introduction to nucleation and growth within the context of metal nanocrystal synthesis, followed by a discussion of the possible shapes that a metal nanocrystal might take under different conditions. We then focus on a variety of experimental parameters that have been explored to manipulate the nucleation and growth of metal nanocrystals in solution-phase syntheses in an effort to generate specific shapes. We then elaborate on these approaches by selecting examples in which there is already reasonable understanding for the observed shape control or at least the protocols have proven to be reproducible and controllable. Finally, we highlight a number of applications that have been enabled and/or enhanced by the shape-controlled synthesis of metal nanocrystals. We conclude this article with personal perspectives on the directions toward which future research in this field might take.

4,927 citations