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Amit Singh

Bio: Amit Singh is an academic researcher from National Institute of Technology, Patna. The author has contributed to research in topics: Digital watermarking & Watermark. The author has an hindex of 57, co-authored 640 publications receiving 13795 citations. Previous affiliations of Amit Singh include Ithaca College & Center for Infectious Disease Research and Policy.


Papers
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Journal ArticleDOI
15 Nov 2016
TL;DR: By publishing peer review reports with published papers, the most transparent and toughest ‘Advanced OPEN peer review’ system will be helpful to many authors for drafting their article according to the specifications and will help to eradicate any possible malicious/purposeful interference by any person during peer review.
Abstract: In African countries Ebola virus has been responsible for several deaths. In addition to being a global health concern, the virus is also considered a potential biological threat. Ebola viruses are incompletely understood pathogens that cause severe, often fatal, illnesses in humans and non-human primates. Ebola virus disease affects most of the human being and finally mortality rate increases in that county. Most of the countries are on alert for the ebola virus because peoples have worked within the boundaries of the affected area of Africa. Such people are not permitted to enter in the resident country without proper test at airport or other places. In this review we have discussed ebola virus disease and it affects the peoples worldwide. Peer Review History: Article received on- 3 August; Revised on- 10 September; Accepted on- 15 October , Available online 15 November 2016 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Dr. Viney Chawla, University Institute of Pharmaceutical Sciences, Baba Farid University of Health Sciences, Sadiq Road, Faridkot-Punjab 151203, drvineychawla@gmail.com Dr. Tamer Elhabibi, Suez Canal University, Egypt, tamer_hassan@pharm.suez.edu.eg

2 citations

Posted ContentDOI
07 May 2019-bioRxiv
TL;DR: It is shown that exosomes secreted by macrophages infected with Mtb, including drug-resistant clinical strains, reactivate HIV-1 by inducing oxidative stress, and new paradigms for understanding the redox and bioenergetics basis of HIV-TB co-infection are uncovered.
Abstract: The synergy between Mycobacterium tuberculosis (Mtb) and HIV-1 interferes with therapy and facilitates pathogenesis of both human pathogens. Fundamental mechanisms by which Mtb exacerbates HIV-1 are not clear. Here, we show that exosomes secreted by macrophages infected with Mtb, including drug-resistant clinical strains, reactivate HIV-1 by inducing oxidative stress. Mechanistically, Mtb-specific exosomes realign mitochondrial and non-mitochondrial oxygen consumption rate (OCR) and modulates the expression of genes mediating oxidative stress response, inflammation, and HIV-1 transactivation. Proteomics revealed the enrichment of several host factors (e.g., HIF-1α, galectins, Hsp90) known to promote HIV-1 reactivation in the Mtb-specific exosomes. Treatment with a known antioxidant, N-acetyl cysteine, or with the inhibitors of host factors galectins and Hsp90 attenuated HIV-1 reactivation by Mtb-specific exosomes. Our findings uncovered new paradigms for understanding the redox and bioenergetics basis of HIV-TB co-infection, which will enable the design of effective therapeutic strategies.

2 citations

10 Aug 2017
TL;DR: This study demonstrates the importance of elucidating the social and cultural contexts in which dietary behaviors exist, especially when considering contradictory mainstream approaches to health promotion, and provides valuable information to develop qualitative measures for empirical assessment, develop and evaluate targeted interventions.
Abstract: India is a country where different type of languages, culture & food habits are in use. There is tremendous regional diversity in their daily diets. Indian cuisine reflects a more than 5,000 year history of various groups and cultures interacting with the subcontinent, leading to diversity of flavors and regional cuisines found in modern-day India. Dietary pattern analysis is an emerging area of research. This study demonstrates the importance of elucidating the social and cultural contexts in which dietary behaviors exist, especially when considering contradictory mainstream approaches to health promotion. Most of the food items were developed by keeping the health aspect in mind and some of the foods were directly used as homemade medicine for some specific diseases as they had therapeutic value. The previous generations knew very well the medicinal value of some of the spices or other ingredients and as such made it a point to use that ingredient in some food recipe to add medicinal value in it. This made Indian cuisine rich in a wide variety and taste and also helpful for health. It also provides valuable information to develop qualitative measures for empirical assessment, develop and evaluate targeted interventions.

2 citations

Journal ArticleDOI
TL;DR: The present study was done to evaluate and compare the antibacterial efficacy of Doxycycline, Camellia Sinensis, Aloe barbadensis Miller, Azadirachta indica and saline with Sodium hypochlorite as an intracanal irrigant against E.faecalis.
Abstract: Aims and objectives: Successful root canal treatment involves the complete elimination of pathogenic microorganisms from the root canal system. Enterococcus faecalis is one of them which is most commonly detected in asymptomatic persistent endodontic infections. Chemical irrigation of the root canals along with biomechanical preparation helps in the elimination of such microorganisms. Thus, the present study was done to evaluate and compare the antibacterial efficacy of Doxycycline, Camellia Sinensis, Aloe barbadensis Miller, Azadirachta indica and saline with Sodium hypochlorite as an intracanal irrigant against E.faecalis. ComparativeEvaluationofAntibacterialEfficacyofAloeBarbadensisMillerCamelliaSinensisAzadirachtaIndicaandDoxycyclinewithSodiumHypochloriteasRootCanalIrr igantAgainstEFaecalisAnInVitroStudy Strictly as per the compliance and regulations of:

2 citations


Cited by
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28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

18,940 citations

Christopher M. Bishop1
01 Jan 2006
TL;DR: Probability distributions of linear models for regression and classification are given in this article, along with a discussion of combining models and combining models in the context of machine learning and classification.
Abstract: Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.

10,141 citations

Journal ArticleDOI
TL;DR: The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors.
Abstract: The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors. While the organization of the book is similar to previous editions, major emphasis has been placed on disorders that affect multiple organ systems. Important advances in genetics, immunology, and oncology are emphasized. Many chapters of the book have been rewritten and describe major advances in internal medicine. Subjects that received only a paragraph or two of attention in previous editions are now covered in entire chapters. Among the chapters that have been extensively revised are the chapters on infections in the compromised host, on skin rashes in infections, on many of the viral infections, including cytomegalovirus and Epstein-Barr virus, on sexually transmitted diseases, on diabetes mellitus, on disorders of bone and mineral metabolism, and on lymphadenopathy and splenomegaly. The major revisions in these chapters and many

6,968 citations

Journal ArticleDOI
TL;DR: A comprehensive review of current research activities that center on the shape-controlled synthesis of metal nanocrystals, including a brief introduction to nucleation and growth within the context of metal Nanocrystal synthesis, followed by a discussion of the possible shapes that aMetal nanocrystal might take under different conditions.
Abstract: Nanocrystals are fundamental to modern science and technology. Mastery over the shape of a nanocrystal enables control of its properties and enhancement of its usefulness for a given application. Our aim is to present a comprehensive review of current research activities that center on the shape-controlled synthesis of metal nanocrystals. We begin with a brief introduction to nucleation and growth within the context of metal nanocrystal synthesis, followed by a discussion of the possible shapes that a metal nanocrystal might take under different conditions. We then focus on a variety of experimental parameters that have been explored to manipulate the nucleation and growth of metal nanocrystals in solution-phase syntheses in an effort to generate specific shapes. We then elaborate on these approaches by selecting examples in which there is already reasonable understanding for the observed shape control or at least the protocols have proven to be reproducible and controllable. Finally, we highlight a number of applications that have been enabled and/or enhanced by the shape-controlled synthesis of metal nanocrystals. We conclude this article with personal perspectives on the directions toward which future research in this field might take.

4,927 citations