A
Amos Toren
Researcher at Sheba Medical Center
Publications - 201
Citations - 5381
Amos Toren is an academic researcher from Sheba Medical Center. The author has contributed to research in topics: Hematopoietic stem cell transplantation & Transplantation. The author has an hindex of 35, co-authored 186 publications receiving 4723 citations. Previous affiliations of Amos Toren include Tel Aviv University.
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Journal ArticleDOI
Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient
Ninette Amariglio,Abraham Hirshberg,Bernd W. Scheithauer,Yoram Cohen,Ron Loewenthal,Luba Trakhtenbrot,Nurit Paz,Maya Koren-Michowitz,Dalia Waldman,Leonor Leider-Trejo,Amos Toren,Shlomi Constantini,Gideon Rechavi +12 more
TL;DR: The findings here suggest that neuronal stem/progenitor cells may be involved in gliomagenesis and provide the first example of a donor-derived brain tumor complicating neural stem cell therapy.
Journal ArticleDOI
Nonmuscle Myosin Heavy Chain IIA Mutations Define a Spectrum of Autosomal Dominant Macrothrombocytopenias: May-Hegglin Anomaly and Fechtner, Sebastian, Epstein, and Alport-Like Syndromes
Karen E. Heath,Angel Campos-Barros,Amos Toren,Galit Rozenfeld-Granot,Lena E. Carlsson,Judy Savige,Joyce C. Denison,Martin C. Gregory,James G. White,D. Barker,Andreas Greinacher,Charles J. Epstein,Marc J. Glucksman,Marc J. Glucksman,John A. Martignetti +14 more
TL;DR: The data suggest that MHA, SBS, FTNS, EPS, and APSM comprise a phenotypic spectrum of disorders, all caused by MYH9 mutations, and the name "MYHIIA syndrome" is proposed to encompass all of these disorders.
Journal ArticleDOI
Early and late hematologic toxicity following CD19 CAR-T cells
Shalev Fried,Shalev Fried,Abraham Avigdor,Abraham Avigdor,Bella Bielorai,Bella Bielorai,Amilia Meir,Michal J. Besser,Michal J. Besser,Jacob Schachter,Jacob Schachter,Avichai Shimoni,Avichai Shimoni,Arnon Nagler,Arnon Nagler,Amos Toren,Elad Jacoby +16 more
TL;DR: Interestingly, since these events occur late after the lymphodepleting chemotherapy and after resolution of CRS, perturbations in SDF-1 levels to correlate with events of late neutropenia, likely associated with B-cell recovery.
Journal ArticleDOI
MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1
Ariel Bier,Niss Giladi,Noam Kronfeld,Hae Kyung Lee,Simona Cazacu,Susan Finniss,Cunli Xiang,Laila M. Poisson,Ana C. deCarvalho,Shimon Slavin,Elad Jacoby,Michal Yalon,Amos Toren,Tom Mikkelsen,Chaya Brodie +14 more
TL;DR: It is demonstrated that miR-137 is downregulated in GBM probably due to promoter hypermethylation and RTVP-1 is attractive therapeutic targets for the eradication of GSCs and for the treatment of GBM.
Journal ArticleDOI
A Congenital Neutrophil Defect Syndrome Associated with Mutations in VPS45
Thierry Vilboux,Atar Lev,May Christine V. Malicdan,Amos J. Simon,Päivi M Järvinen,Tomas Racek,Jacek Puchałka,Raman Sood,Blake Carrington,Kevin Bishop,James C. Mullikin,Marjan Huizing,Ben Zion Garty,Eran Eyal,Baruch Wolach,Ronit Gavrieli,Amos Toren,Amos Toren,Michalle Soudack,Michalle Soudack,Osama M. Atawneh,Tatiana Babushkin,Tatiana Babushkin,Ginette Schiby,Ginette Schiby,Andrew R. Cullinane,Camila Avivi,Camila Avivi,Sylvie Polak-Charcon,Sylvie Polak-Charcon,Iris Barshack,Iris Barshack,Ninette Amariglio,Gideon Rechavi,Jutte van der Werff ten Bosch,Yair Anikster,Yair Anikster,Christoph Klein,William A. Gahl,Raz Somech,Raz Somech +40 more
TL;DR: Defective endosomal intracellular protein trafficking due to biallelic mutations in VPS45 underlies a new immunodeficiency syndrome involving impaired neutrophil function.