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Amr M. Abdelmoniem

Other affiliations: Leibniz University of Hanover
Bio: Amr M. Abdelmoniem is an academic researcher from Cairo University. The author has contributed to research in topics: Dimedone & Quinoline. The author has an hindex of 10, co-authored 42 publications receiving 288 citations. Previous affiliations of Amr M. Abdelmoniem include Leibniz University of Hanover.

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TL;DR: 3-Cyanomethylidene oxindole derivatives were prepared in excellent yields utilizing DBU-promoted Knoevenagel condensation of isatin derivatives with active methylene reagents to yield spirocyclic 2-oxindoles derivatives with incorporated 6-amino-4H-pyridazines and their fused derivatives.

38 citations

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TL;DR: Evidence of the potent effect of the new compound 6a is provided and assists in the progress of new healing agents for cancer, as it inhibits proliferation, cell cycle progression and induces apoptosis of tumor cells.
Abstract: An efficient one pot synthesis of bis spiro-cyclic 2-oxindole derivatives of pyrimido[4,5-b]quinoline-4,6-dione using 6-aminouracil, bis-isatin and dimedone has been developed. The cytotoxic effect against different human cell lines MCF7, HCT116 and A549 cell lines was evaluated. The derivative 6a, was found the most encouraging compound in this series and it was selected for molecular studies against MCF7. Our data indicated that compound 6a is an attractive target for breast cancer, as it inhibits proliferation, cell cycle progression and induces apoptosis of tumor cells. This inhibition is mediated by fragmentation of genomic DNA, up-regulation of [caspase-3, tumor suppressor gene p53, and pro-apoptotic gene BAX], and down-regulation of anti-apoptotic BCL2 gene. In additions it caused cell cycle arrest in S phase. This work provides an evidence of the potent effect of the new compound 6a and assists in the progress of new healing agents for cancer.

37 citations

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TL;DR: In this article, a clean and efficient methodologies involving one-pot three-component synthesis of bis-aldehydes, malonitrile dimer, and dimedone in the presence of piperidine as a catalyst in EtOH was presented.

32 citations


Cited by
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[...]

08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

Journal ArticleDOI
TL;DR: In this article, a review of the catalytic activity of sulfonic acid-functionalized SBA-15 has been performed and it has been shown that the SBA can be easily removed from the reaction mixture by simple filtration, recovered and reused without significant loss of activity.
Abstract: Mesoporous silica SBA-15 has been functionalized with sulfonic acid to create highly powerful heterogeneous solid acid catalysts (SBA-Pr-SO 3 H). The catalyst can be easily removed from the reaction mixture by simple filtration, recovered and reused without significant loss of activity. In this review, the catalytic activity of sulfonic acid-functionalized SBA-15 has been widely studied.

134 citations

Journal ArticleDOI
TL;DR: An overview of different applications and developments of spirooxindoles (including the related natural products and their derivatives) in the process of drug innovation, including such as in anticancer, antimicrobial, anti–inflammatory, analgesic, antioxidant, antimalarial, and antiviral activities is offered.
Abstract: Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the application of medicine, quite a few compounds featuring spirooxindole motif have displayed excellent and broad pharmacological activities. Many identified candidate molecules have been used in clinical trials, showing promising prospects.Areas covered: This article offers an overview of different applications and developments of spirooxindoles (including the related natural products and their derivatives) in the process of drug innovation, including such as in anticancer, antimicrobial, anti-inflammatory, analgesic, antioxidant, antimalarial, and antiviral activities. Furthermore, the crucial structure-activity relationships, molecular mechanisms, pharmacokinetic properties, and main synthetic methods of spirooxindoles-based derivatives are also reviewed.Expert opinion: Recent progress in the biological activity profiles of spirooxindole derivatives have demonstrated their significant position in present-day drug discovery. Furthermore, we believe that the multidirectional development of novel drugs containing this core scaffold will continue to be the research hotspot in medicinal chemistry in the future.

126 citations

Journal ArticleDOI
TL;DR: In this paper, a one-pot three-component reaction of substituted aromatic aldehydes, dicarbonyl- and 2-aminobenzothiazole/3-amino-1,2,4-triazole/urea/thiourea using commercially available chitosan in 2% acetic acid in aqueous media at 60-65 °C was described.
Abstract: A convenient and rapid method is described for the synthesis of nitrogen heterocyclic derivatives by one-pot three-component reaction of substituted aromatic aldehydes, dicarbonyl- and 2-aminobenzothiazole/3-amino-1,2,4-triazole/urea/thiourea using commercially available chitosan in 2% acetic acid in aqueous media at 60–65 °C. Chitosan was used as an efficient biodegradable and reusable green catalyst for this multicomponent reaction. The chitosan catalyst can be reused 10 times in fresh reaction. Catalytic activity has been sustained in the first five runs but slightly decreased in subsequent cycles.

94 citations