A
Amrita Mandal
Researcher at National Institutes of Health
Publications - 11
Citations - 317
Amrita Mandal is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Zebrafish & Retinoic acid. The author has an hindex of 6, co-authored 9 publications receiving 207 citations. Previous affiliations of Amrita Mandal include Cincinnati Children's Hospital Medical Center & Boston Children's Hospital.
Papers
More filters
Journal ArticleDOI
Axonal Transport and Mitochondrial Function in Neurons.
TL;DR: Current understanding on transport-dependent mechanisms that regulate mitochondrial replenishment are reviewed, focusing on axonal transport and import of mRNAs and proteins destined for mitochondria as well as mitochondrial fusion and fission to maintain mitochondrial homeostasis in distal compartments of the neuron.
Journal ArticleDOI
Depletion of retinoic acid receptors initiates a novel positive feedback mechanism that promotes teratogenic increases in retinoic acid.
TL;DR: It is reported that zebrafish embryos deficient for RA receptor αb1 (RARαb1), a conserved RAR splice variant, have enlarged hearts with increased cardiomyocyte (CM) specification, which are surprisingly the consequence of increased RA signaling.
Journal ArticleDOI
Analyzing Neuronal Mitochondria in vivo Using Fluorescent Reporters in Zebrafish.
TL;DR: Using tools and techniques optimized to directly visualize mitochondria and analyze mitochondrial lifetime, health, and function in neurons in vivo using fluorescent reporters in the zebrafish, the field is poised to answer questions of mitochondrial biology in the context of neuronal health andfunction in normal and disease states.
Journal ArticleDOI
Transgenic retinoic acid sensor lines in zebrafish indicate regions of available embryonic retinoic acid.
Amrita Mandal,Amrita Mandal,Ariel Rydeen,Ariel Rydeen,Jane Anderson,Mollie R.J. Sorrell,Tomas Zygmunt,Jesús Torres-Vázquez,Joshua S. Waxman +8 more
TL;DR: Novel transgenic RA sensors in which a RA receptor (RAR) ligand‐binding domain (RLBD) is fused to the Gal4 DNA‐ binding domain (GDBD) or a VP16‐G DBD (VPBD) construct are generated, demonstrating there may be almost ubiquitous availability of RA within the early embryo.
Journal ArticleDOI
Retrograde Mitochondrial Transport Is Essential for Organelle Distribution and Health in Zebrafish Neurons.
Amrita Mandal,Hiu-Tung C. Wong,Katherine Pinter,Natalie Mosqueda,Alisha Beirl,Richa Madan Lomash,Sehoon Won,Katie S. Kindt,Catherine M. Drerup +8 more
TL;DR: In this paper, the authors show that retrograde transport of mitochondria from axon terminals allows replacement of the axon terminal population within a day, but not all mitochondria that leave the axons are degraded; rather, they persist over several days.