A
Amy K. Reeve
Researcher at Newcastle University
Publications - 53
Citations - 4364
Amy K. Reeve is an academic researcher from Newcastle University. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 26, co-authored 52 publications receiving 3739 citations. Previous affiliations of Amy K. Reeve include Wellcome Trust.
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Journal ArticleDOI
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease.
Andreas Bender,Kim J. Krishnan,Christopher Morris,Geoffrey A. Taylor,Amy K. Reeve,Robert H. Perry,Evelyn Jaros,Joshua S Hersheson,Joanne Betts,Thomas Klopstock,Robert W. Taylor,Douglass M. Turnbull +11 more
TL;DR: It is shown that in substantia nigra neurons from both aged controls and individuals with Parkinson disease, there is a high level of deleted mitochondrial DNA, suggesting that somatic mtDNA deletions are important in the selective neuronal loss observed in brain aging and in Parkinson disease.
Journal ArticleDOI
What causes mitochondrial DNA deletions in human cells
Kim J. Krishnan,Amy K. Reeve,David C. Samuels,Patrick F. Chinnery,John K. Blackwood,Robert W. Taylor,Sjoerd Wanrooij,Johannes N. Spelbrink,Robert N. Lightowlers,Douglass M. Turnbull +9 more
TL;DR: It is concluded that mtDNA deletions are most likely to occur during repair of damaged mtDNA rather than during replication, having important implications for prevention of mtDNA disease and, potentially, for the understanding of the aging process.
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Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis
Graham R. Campbell,Iryna Ziabreva,Amy K. Reeve,Kim J. Krishnan,Richard Reynolds,Owen Howell,Hans Lassmann,Douglass M. Turnbull,Don J. Mahad +8 more
TL;DR: This work explored mitochondrial respiratory chain activity and mtDNA deletions in single neurons from secondary progressive MS (SPMS) cases and concluded that mitochondria are established to play a part in the pathogenesis of MS.
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Mitochondrial DNA and disease
TL;DR: The unique characteristics of mitochondrial genetics are outlined before detailing important pathological features of mt DNA diseases, focusing on adult neurological disease as well as the role of mtDNA mutations in neurodegenerative diseases, ageing and cancer.
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Mitochondrial Dysfunction in Parkinson's Disease-Cause or Consequence?
TL;DR: Whether the mitochondrial dysfunction the authors have detected in Parkinson’s disease is a pathogenic cause of neuronal loss or whether it is itself a consequence of dysfunction in other pathways is discussed.