A
An Xu
Researcher at Second Military Medical University
Publications - 4
Citations - 161
An Xu is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Downregulation and upregulation & Transactivation. The author has an hindex of 4, co-authored 4 publications receiving 121 citations.
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Journal ArticleDOI
PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression.
Tao Luo,Jing Fu,An Xu,Bo Su,Yibing Ren,Ning Li,Junjie Zhu,Xiaofang Zhao,Rongyang Dai,Jie Cao,Bibo Wang,Wenhao Qin,Jinhua Jiang,Juan Li,Meng-Chao Wu,Gen-Sheng Feng,Yao Chen,Hongyang Wang +17 more
TL;DR: It is reported that PSMD10/gankyrin promotes autophagy in hepatocellular carcinoma (HCC) in response to starvation or stress through 2 complementary routes, and this results present a novel mechanism involving modulation of ATG7 by PS MD10 in sustainingAutophagy, promoting HCC cell survival against starvation or chemotherapy.
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Contradictory effects of mitochondria- and non-mitochondria-targeted antioxidants on hepatocarcinogenesis by altering DNA repair in mice.
TL;DR: The results demonstrate that the type of antioxidants plays a previously unappreciated role in hepatocarcinogenesis, and provide a mechanistic rationale for exploring the therapeutic use of antioxidants for liver cancer.
Journal ArticleDOI
Targeting interleukin-1 receptor-associated kinase 1 for human hepatocellular carcinoma
Ning Li,Jinhua Jiang,Fu Jing,Ting Yu,Bibo Wang,Wenhao Qin,An Xu,Mengchao Wu,Chen Yao,Hongyang Wang +9 more
TL;DR: Interleukin-1 receptor associated kinase 1 promotes cell proliferation and protects against apoptosis in HCC, and can be a novel target for HCC treatment.
Journal ArticleDOI
Diet-induced hepatic steatosis activates Ras to promote hepatocarcinogenesis via CPT1α.
An Xu,Bibo Wang,Jing Fu,Wenhao Qin,Ting Yu,Zhishi Yang,Qingjun Lu,Jingyi Chen,Yao Chen,Hongyang Wang +9 more
TL;DR: Interestingly, hepatic steatosis could be alleviated by persistent activation of Ras, whereas Ras accelerated DNA damage and HCC progression through Carnitine palmitoyltransferase 1A (CPT1α), which can provide a novel link between Steatosis and Ras activity in liver cancer.