J. Appl. Cryst.の発刊に際して

1. Type 1 diabetes (due to b-cell destruction, usually leading to absolute insulin deficiency) 2. Type 2 diabetes (due to a progressive insulin secretory defect on the background of insulin resistance) 3. Gestational diabetes mellitus (GDM) (diabetes diagnosed in the second or third trimester of pregnancy that is not clearly overt diabetes) 4. Specific types of diabetes due to other causes, e.g., monogenic diabetes syndromes (such as neonatal diabetes and maturity-onset diabetes of the young [MODY]), diseases of the exocrine pancreas (such as cystic fibrosis), and drugor chemical-induced diabetes (such as in the treatment of HIV/AIDS or after organ transplantation)

Classification and diagnosis of diabetes

Interpretation of X-ray Powder Diffraction Patterns . By H. Lipson and H. Steeple. Pp. viii + 335 + 3 plates. (Mac-millan: London; St Martins Press: New York, May 1970.) £4.

X-Ray Diffraction

X-ray radiographic absorption imaging is an invaluable tool in medical diagnostics and materials science. For biological tissue samples, polymers or fibre composites, however, the use of conventional X-ray radiography is limited due to their weak absorption. This is resolved at highly brilliant X-ray synchrotron or micro-focus sources by using phase-sensitive imaging methods to improve the contrast1,2. However, the requirements of the illuminating radiation mean that hard-X-ray phase-sensitive imaging has until now been impractical with more readily available X-ray sources, such as X-ray tubes. In this letter, we report how a setup consisting of three transmission gratings can efficiently yield quantitative differential phase-contrast images with conventional X-ray tubes. In contrast with existing techniques, the method requires no spatial or temporal coherence, is mechanically robust, and can be scaled up to large fields of view. Our method provides all the benefits of contrast-enhanced phase-sensitive imaging, but is also fully compatible with conventional absorption radiography. It is applicable to X-ray medical imaging, industrial non-destructive testing, and to other low-brilliance radiation, such as neutrons or atoms.

http://xrm.phys.northwestern.edu/research/pdf_papers/2006/pfeiffer_naturephys_2006.pdf

Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources

50 Years of Image Analysis

Using a high-efficiency grating interferometer for hard X rays (10-30 keV) and a phase-stepping technique, separate radiographs of the phase and absorption profiles of bulk samples can be obtained from a single set of measurements. Tomographic reconstruction yields quantitative three-dimensional maps of the X-ray refractive index, with a spatial resolution down to a few microns. The method is mechanically robust, requires little spatial coherence and monochromaticity, and can be scaled up to large fields of view, with a detector of correspondingly moderate spatial resolution. These are important prerequisites for use with laboratory X-ray sources.

/pdf/x-ray-phase-imaging-with-a-grating-interferometer-4px897qwex.pdf

X-ray phase imaging with a grating interferometer.

Accurate knowledge of translation positions is essential in ptychography to achieve a good image quality and the diffraction limited resolution. We propose a method to retrieve and correct position errors during the image reconstruction iterations. Sub-pixel position accuracy after refinement is shown to be achievable within several tens of iterations. Simulation and experimental results for both optical and X-ray wavelengths are given. The method improves both the quality of the retrieved object image and relaxes the position accuracy requirement while acquiring the diffraction patterns.

Translation position determination in ptychographic coherent diffraction imaging

X-ray ptychography is a scanning variant of coherent diffractive imaging with the ability to image large fields of view at high resolution. It further allows imaging of non-isolated specimens and can produce quantitative mapping of the electron density distribution in 3D when combined with computed tomography. The method does not require imaging lenses, which makes it dose efficient and suitable to multi-keV X-rays, where efficient photon counting, pixelated detectors are available. Here we present the first highly resolved quantitative X-ray ptychographic tomography of an extended object yielding 16 nm isotropic 3D resolution recorded at 2 A wavelength. This first-of-its-kind demonstration paves the way for ptychographic X-ray tomography to become a promising method for X-ray imaging of representative sample volumes at unmatched resolution, opening tremendous potential for characterizing samples in materials science and biology by filling the resolution gap between electron microscopy and other X-ray imaging techniques.

/pdf/x-ray-ptychographic-computed-tomography-at-16-nm-isotropic-2wh5qs9pec.pdf

X-ray ptychographic computed tomography at 16 nm isotropic 3D resolution

Fabrication of diffraction gratings for hard X-ray phase contrast imaging

X-ray ptychography is a scanning variant of coherent diffractive imaging with the ability to image largefields of view at high resolution. It further allows imaging of non-isolated specimens and can producequantitative mapping of the electron density distribution in 3D when combined with computedtomography. The method does not require imaging lenses, which makes it dose efficient and suitable tomulti-keV X-rays, where efficient photon counting, pixelated detectors are available. Here we present thefirst highly resolved quantitative X-ray ptychographic tomography of an extended object yielding 16 nmisotropic 3D resolution recorded at 2 A˚ wavelength. This first-of-its-kind demonstration paves the way forptychographic X-ray tomography to become a promising method for X-ray imaging of representativesample volumes at unmatched resolution, opening tremendous potential for characterizing samples inmaterials science and biology by filling the resolution gap between electron microscopy and other X-rayimaging techniques.

Ana Diaz

Papers

X-ray phase imaging with a grating interferometer.

Translation position determination in ptychographic coherent diffraction imaging

X-ray ptychographic computed tomography at 16 nm isotropic 3D resolution

Fabrication of diffraction gratings for hard X-ray phase contrast imaging

X-ray ptychographic computed tomography at 16 nm isotropic 3D