Author
Ana M. Rodríguez
Other affiliations: Max Planck Society
Bio: Ana M. Rodríguez is an academic researcher from University of Castilla–La Mancha. The author has contributed to research in topics: Ligand & Catalysis. The author has an hindex of 35, co-authored 216 publications receiving 4335 citations. Previous affiliations of Ana M. Rodríguez include Max Planck Society.
Topics: Ligand, Catalysis, Ruthenium, Enantiopure drug, Reaction rate constant
Papers published on a yearly basis
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TL;DR: Ruthenium derivatives of the type [RuCl(arene)(NN)][BPh4] (arene = benzene, p-cymene) have been synthesized with NN = 2-hydroxyphenylbis(pyrazol-1-yl)methane (bpzmArOH) or 2hydroxymynylbis (3,5-di... as mentioned in this paper.
93 citations
TL;DR: The reaction of the sterically hindered heteroscorpionate lithium acetamidinate [Li(κ3-pbptamd)(THF)] was shown in this paper.
92 citations
TL;DR: An enantiopure neodymium complex acts as an efficient single-site initiator for the controlled ring-opening polymerization of rac-lactide, forming isotactic polyester.
Abstract: With a sting in its tail: An enantiopure neodymium complex (see scheme) acts as an efficient single-site initiator for the controlled ring-opening polymerization of rac-lactide, forming isotactic polyester. The heteroscorpionate complex was characterized spectroscopically and by X-ray diffraction.
85 citations
TL;DR: In this paper, a mechanism involving the formation of amido intermediates was proposed for the catalytic addition of amines to carbodiimides in an insertion process, and the resulting amido compounds subsequently react with the carbodicimide.
79 citations
TL;DR: The cytototoxic activity of the new ruthenium(II) arene compounds has been evaluated in several cell lines and their CDK1 inhibitory effect suggest a multitarget mechanism for their biological activity.
Abstract: The ligands 2-pyridin-2-yl-1H-benzimidazole (HL1), 1-methyl-2-pyridin-2-ylbenzimidazole (HL2), and 2-(1H-imidazol-2-yl)pyridine (HL3) and the proligand 2-phenyl-1H-benzimidazole (HL4) have been used to prepare five different types of new ruthenium(II) arene compounds: (i) monocationic complexes with the general formula [(η6-arene)RuCl(κ2-N,N-HL)]Y [HL = HL1, HL2, or HL3; Y = Cl or BF4; arene = 2-phenoxyethanol (phoxet), benzene (bz), or p-cymene (p-cym)]; (ii) dicationic aqua complexes of the formula [(η6-arene)Ru(OH2)(κ2-N,N-HL1)](Y)2 (Y = Cl or TfO; arene = phoxet, bz, or p-cym); (iii) the nucleobase derivative [(η6-arene)Ru(9-MeG)(κ2-N,N-HL1)](PF6)2 (9-MeG = 9-methylguanine); (iv) neutral complexes consistent with the formulation [(η6-arene)RuCl(κ2-N,N-L1)] (arene = bz or p-cym); (v) the neutral cyclometalated complex [(η6-p-cym)RuCl(κ2-N,C-L4)]. The cytototoxic activity of the new ruthenium(II) arene compounds has been evaluated in several cell lines (MCR-5, MCF-7, A2780, and A2780cis) in order to est...
77 citations
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TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.
Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …
33,785 citations
TL;DR: The development of novel materials is a fundamental focal point of chemical research; and this interest is mandated by advancements in all areas of industry and technology.
Abstract: The development of novel materials is a fundamental focal point of chemical research; and this interest is mandated by advancements in all areas of industry and technology. A good example of the synergism between scientific discovery and technological development is the electronics industry, where discoveries of new semiconducting materials resulted in the evolution from vacuum tubes to diodes and transistors, and eventually to miniature chips. The progression of this technology led to the development * To whom correspondence should be addressed. B.L.C.: (504) 2801385 (phone); (504) 280-3185 (fax); bcushing@uno.edu (e-mail). C.J.O.: (504)280-6846(phone);(504)280-3185(fax);coconnor@uno.edu (e-mail). 3893 Chem. Rev. 2004, 104, 3893−3946
2,621 citations
1,307 citations
1,256 citations
TL;DR: This review describes a multidimensional treatment of molecular recognition phenomena involving aromatic rings in chemical and biological systems that facilitates the development of new advanced materials and supramolecular systems, and should inspire further utilization of interactions with aromatic rings to control the stereochemical outcome of synthetic transformations.
Abstract: This review describes a multidimensional treatment of molecular recognition phenomena involving aromatic rings in chemical and biological systems. It summarizes new results reported since the appearance of an earlier review in 2003 in host-guest chemistry, biological affinity assays and biostructural analysis, data base mining in the Cambridge Structural Database (CSD) and the Protein Data Bank (PDB), and advanced computational studies. Topics addressed are arene-arene, perfluoroarene-arene, S⋅⋅⋅aromatic, cation-π, and anion-π interactions, as well as hydrogen bonding to π systems. The generated knowledge benefits, in particular, structure-based hit-to-lead development and lead optimization both in the pharmaceutical and in the crop protection industry. It equally facilitates the development of new advanced materials and supramolecular systems, and should inspire further utilization of interactions with aromatic rings to control the stereochemical outcome of synthetic transformations.
1,221 citations