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Ana-Maria Florea
Researcher at University of Düsseldorf
Publications - 38
Citations - 3458
Ana-Maria Florea is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Calcium in biology & Cisplatin. The author has an hindex of 25, co-authored 38 publications receiving 2980 citations. Previous affiliations of Ana-Maria Florea include University of Duisburg-Essen & University of California, Davis.
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Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects
TL;DR: Understanding of the biochemical mechanisms triggered by cisplatin in tumor cells may lead to the design of more efficient platinum derivates (or other drugs) and might provide new therapeutic strategies and reduce side effects.
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Occurrence, use and potential toxic effects of metals and metal compounds.
TL;DR: This mini-review gives an overview on the use and the actions of selected metal species of actual scientific concern, with a focus on neuronal cells.
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Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)
TL;DR: The potential of SMAC mimetics as effective single agent or combinatory therapies to treat cancer is highlighted and the likely clinical implications of resistance toSMAC mimetic therapy, occasionally observed in cancer cell lines are discussed.
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Uptake of inorganic and organic derivatives of arsenic associated with induced cytotoxic and genotoxic effects in Chinese hamster ovary (CHO) cells
Elke Dopp,L. M. Hartmann,Ana-Maria Florea,U. von Recklinghausen,R. Pieper,B. Shokouhi,Albert W. Rettenmeier,Alfred V. Hirner,Günter Obe +8 more
TL;DR: The data demonstrate that arsenic compounds in the trivalent oxidation state exhibit the strongest genotoxic effects, and postulate that the induction of genot toxic effects caused by the methylated arsenic species is primarily dependent upon their ability to penetrate cell membranes.
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Environmental Distribution, Analysis, and Toxicity of Organometal(loid) Compounds
TL;DR: An overview about the environmental distribution of organometal(loid) compounds and the potential hazardous effects on animal and human health is given.