Author
Ana Maria Soares Pereira
Other affiliations: Universidade Federal do Rio Grande do Sul, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto
Bio: Ana Maria Soares Pereira is an academic researcher from Universidade de Ribeirão Preto. The author has contributed to research in topics: Celastraceae & Micropropagation. The author has an hindex of 26, co-authored 155 publications receiving 2454 citations. Previous affiliations of Ana Maria Soares Pereira include Universidade Federal do Rio Grande do Sul & Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto.
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TL;DR: The EO of O. gratissimum is an effective and safe anesthetic for silver catfish, and its mechanism seems to be related to an interaction with the GABA A -benzodiazepine receptor.
100 citations
TL;DR: The possible advantages of using herbal medicines instead of purified compounds, the truth and myths about herbal medicines, drug discovery, and the implications for medical education and health care are discussed.
Abstract: Men have been using herbal medicines for thousands of years. The advantages of this type of therapeutics include good availability, local cultural aspects, individual preferences, the increasing demand for natural and organic products, and the already validated synergistic effects of herbal medicines. However, ethically, the scope and limits of these drugs need to be established not only by ethnopharmacological evidences but also by scientific investigations, which confirm the therapeutic effects. With this study, we propose to discuss the possible advantages of using herbal medicines instead of purified compounds, the truth and myths about herbal medicines, drug discovery, and the implications for medical education and health care.
96 citations
TL;DR: The present study evaluated the potential of essential oils of three Brazilian native plants as anesthetics for the silver catfish - Rhamdia quelen, and found that only the EO of H. ringens and O. acutifolia were effective as ansthetics, without behavioral side effects.
Abstract: There is an increasing demand for inexpensive and safe anesthetics that can reduce fish stress caused by some procedures such as capture and handling. In this context, the present study evaluated the potential of essential oils (EO) of three Brazilian native plants (Hesperozygis ringens, Lippia sidoides and Ocotea acutifolia) as anesthetics for the silver catfish - Rhamdia quelen. Moreover, an analysis was made of the chemical composition of these oils and their influence on stress parameter. EO of H. ringens and O. acutifolia were effective as anesthetics, without behavioral side effects. EO of O. acutifolia (150 µL L-1) promoted an increase in blood glucose level. Regarding to the composition, pulegone accounts for 96.63% of the EO of H. ringens, and caryophyllene oxide amounts to 56.90% of the EO of O. acutifolia. Two chemotypes, thymol and carvacrol (68.40% and 67.89%, respectively) were verified for EO of L. sidoides. Both samples of EO of L. sidoides showed anesthetic activity in silver catfish, but exposure also caused loss of mucus and mortality. Thus, only the EO of H. ringens and O. acutifolia are advised for anesthetic use
75 citations
TL;DR: The crude aqueous extract from subterranean system of Mandevilla velutina, a plant found in Brazilian savanna, was assayed for its ability to inhibit biological activities of several snake venoms and isolated PLA(2)s, and Extracts of 18 month old micropropagated plants were able to partially neutralize the effect of the crude venom and toxins.
70 citations
TL;DR: These experiments indicated that the triterpenes once biosynthesized in the leaves are translocated to the root bark and further transformed to the antitumoral quinonemethide triter penoids.
68 citations
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992 citations
TL;DR: Neuroinflammation drives widespread chronic pain via central sensitization and sex-dependent glial/immune signaling in chronic pain and new therapeutic approaches that control neuroinflammation for the resolution of chronic pain are discussed.
Abstract: Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic plasticity, and increased neuronal responsiveness in central pain pathways after painful insults Accumulating evidence suggests that central sensitization is also driven by neuroinflammation in the peripheral and central nervous system A characteristic feature of neuroinflammation is the activation of glial cells, such as microglia and astrocytes, in the spinal cord and brain, leading to the release of proinflammatory cytokines and chemokines Recent studies suggest that central cytokines and chemokines are powerful neuromodulators and play a sufficient role in inducing hyperalgesia and allodynia after central nervous system administration Sustained increase of cytokines and chemokines in the central nervous system also promotes chronic widespread pain that affects multiple body sites Thus, neuroinflammation drives widespread chronic pain via central sensitization We also discuss sex-dependent glial/immune signaling in chronic pain and new therapeutic approaches that control neuroinflammation for the resolution of chronic pain
641 citations
TL;DR: The oleanane skeleton was the most common skeleton and is present in most orders of the plant kingdom, and the relationship between the type of skeleton and the plant origin was investigated.
592 citations
TL;DR: This review describes secondary metabolites that have been shown to be synthesized by symbiotic bacteria, or for which this possibility has been discussed, and includes 365 references.
561 citations
TL;DR: This review evaluated the current research on using EOs as potential larvicides based on their chemical composition and biological efficacy, and found that more than 2/3 of the plants were from only 5 families: Lamiaceae, Cupressaceae, Rutaceae, Apiaceae, and Myrtaceae.
517 citations