Ana Simões

TL;DR: These findings are the first in vivo proof that mutant ataxin 3 proteolysis by calpains mediates its translocation to the nucleus, aggregation and toxicity and that inhibition of cal pains may provide an effective therapy for Machado-Joseph disease.

TL;DR: Caffeine and selective adenosine A2A receptor blockade alleviate neurodegeneration in different brain diseases, namely at early stages of another polyglutamine‐related disorder such as Huntington's disease, and it is tested their ability to control MJD‐associated neurodegenersation.

TL;DR: This innovative and timely review emphasizes that nanosystems constitute a highly promising technology strategy towards the obtainment of superior and ground-breaking cosmetic formulations.

TL;DR: It is demonstrated that amygdala A2ARs control fear memory and the underlying process of synaptic plasticity in this brain region, which provides a neurophysiological basis for the association between A 2AR polymorphisms and phobia or panic attacks in humans and prompts a therapeutic interest in A2 ARs to manage fear-related pathologies.

TL;DR: Oral administration of the calpain inhibitor BDA-410 alleviates Machado-Joseph neuropathology and may therefore be an effective therapeutic option for MJD.