A
Anais Fradet
Researcher at Claude Bernard University Lyon 1
Publications - 4
Citations - 147
Anais Fradet is an academic researcher from Claude Bernard University Lyon 1. The author has contributed to research in topics: Metastasis & Prostate cancer. The author has an hindex of 4, co-authored 4 publications receiving 122 citations. Previous affiliations of Anais Fradet include French Institute of Health and Medical Research & University of Lyon.
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Journal ArticleDOI
Dual Function of ERRα in Breast Cancer and Bone Metastasis Formation: Implication of VEGF and Osteoprotegerin
Anais Fradet,Helene Sorel,Lamia Bouazza,Delphine Goehrig,Baptiste Depalle,Akeila Bellahcene,Vincenzo Castronovo,Hélène Follet,Françoise Descotes,Jane E. Aubin,Philippe Clézardin,Edith Bonnelye +11 more
TL;DR: Results show that ERRα plays a dual role in breast cancer progression in promoting the local growth of tumor cells, but decreasing metastatic growth of osteolytic lesions in bone.
Journal ArticleDOI
Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone.
Anais Fradet,Mathilde Bouchet,Carine Delliaux,Carine Delliaux,Manon Gervais,Casina Kan,Claire Benetollo,Claire Benetollo,Francesco Pantano,Geoffrey Vargas,Lamia Bouazza,Martine Croset,Yohann Bala,Xavier Leroy,Thomas J. Rosol,Jennifer Rieusset,Akeila Bellahcene,Vincenzo Castronovo,Jane E. Aubin,Philippe Clézardin,Martine Duterque-Coquillaud,Martine Duterque-Coquillaud,Edith Bonnelye +22 more
TL;DR: The data demonstrate that ERR α is a regulator of CRPC cell progression in bone, and inhibiting ERRα may constitute a new therapeutic strategy for prostate cancer skeletal-related events.
Journal ArticleDOI
A New Murine Model of Osteoblastic/Osteolytic Lesions from Human Androgen-Resistant Prostate Cancer
Anais Fradet,Anais Fradet,Helene Sorel,Helene Sorel,Baptiste Depalle,Baptiste Depalle,Claire Marie Serre,Claire Marie Serre,Delphine Farlay,Delphine Farlay,Andrei Turtoi,Akeila Bellahcene,Hélène Follet,Hélène Follet,Vincenzo Castronovo,Philippe Clézardin,Philippe Clézardin,Edith Bonnelye,Edith Bonnelye +18 more
TL;DR: A new CRPC cell line is established as a useful system for modeling human metastatic prostate cancer which presents the mixed phenotype of bone metastases that is commonly observed in prostate cancer patients with advanced disease.
Journal ArticleDOI
TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases
Carine Delliaux,Tian V. Tian,Mathilde Bouchet,Anais Fradet,Nathalie Vanpouille,Anne Flourens,Rachel Deplus,Arnauld Villers,Xavier Leroy,Philippe Clézardin,Yvan de Launoit,Edith Bonnelye,Martine Duterque-Coquillaud +12 more
TL;DR: It is found that ectopic expression of the TMPRSS2:ERG fusion enhances the ability of prostate cancer cell lines to induce osteoblastic lesions by stimulating bone formation and inhibiting the osteolytic response.