Anastasia Hrabovsky

TL;DR: The increase observed in differentiating neurons suggests a role in neurogenesis as well, and several lncRNAs that map near SNPs associated with SZ in genome wide association studies also increase during neuronal differentiation, suggesting that these novel transcripts may be abnormally regulated in a subgroup of patients.

TL;DR: Transcriptome profiling revealed that CHD8 hemizygosity (CHD8+/−) affected the expression of several thousands of genes in neural progenitors and early differentiating neurons, and seven of the twelve genes associated with human brain volume or head size by genome-wide association studies were dysregulated in CHD 8+/+ neural progensitors or neurons.

TL;DR: It is shown that the differentially expressed genes converge on a sub-network mediated by CDC45 and the cell cycle, which would be disrupted by the 22q11.2 deletion during embryonic brain development, and another sub- network modulated by PRODH, which could contribute to disruption of brain function during adolescence.

TL;DR: Differentially expressed miRNAs previously identified using autopsy samples and peripheral cells, both of which have significant methodological problems, are indeed disrupted in neuropsychiatric disorders and likely have an underlying genetic basis.

TL;DR: This work identified 801 genes in differentiating neurons that were expressed in an allele-biased manner and identified a number of putative SZ and ASD candidates, such as A2BP1, ERBB4, NLGN4X, NRG1,NRG3, NRXN1, and NLGN1.