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Anders Björklund
Researcher at Lund University
Publications - 771
Citations - 87172
Anders Björklund is an academic researcher from Lund University. The author has contributed to research in topics: Transplantation & Dopamine. The author has an hindex of 165, co-authored 769 publications receiving 84268 citations. Previous affiliations of Anders Björklund include University of Washington & Institute for the Study of Labor.
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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.
Jia-Yi Li,Elisabet Englund,Janice L. Holton,Denis Soulet,Peter Hagell,Andrew J. Lees,Tammaryn Lashley,Niall Quinn,Stig Rehncrona,Anders Björklund,Håkan Widner,Tamas Revesz,Olle Lindvall,Patrik Brundin +13 more
TL;DR: Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11–16 years) developed α-synuclein–positive Lewy bodies in grafted neurons, providing the first evidence, to the authors' knowledge, that the disease can propagate from host to graft cells.
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Dopamine neuron systems in the brain: an update.
TL;DR: The purpose of the present review is to summarize the current knowledge of the diversity and neurochemical features of the nine dopamine-containing neuronal cell groups in the mammalian brain, their distinctive cellular properties, and their ability to regulate their dopaminergic transmitter machinery in response to altered functional demands and aging.
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Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection
Lawrence R. Williams,Silvio Varon,Gary M. Peterson,Klas Wictorin,Walter Fischer,Anders Björklund,Fred H. Gage +6 more
TL;DR: It is reported here that NGF treatment significantly reduces both the total neuronal and cholinergic neuronal death found 2 weeks after fimbria fornix transection; there was a sparing of 50% of the neurons in the MS and essentially 100% of those in the VDB that otherwise would have died.
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Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor.
Walter Fischer,Klas Wictorin,Anders Björklund,Lawrence R. Williams,Silvio Varon,Fred H. Gage +5 more
TL;DR: Continuous intracerebral infusion of NGF over a period of four weeks can partly reverse the cholinergic cell body atrophy and improve retention of a spatial memory task in behaviourally impaired aged rats.
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Cell replacement therapies for central nervous system disorders.
Anders Björklund,Olle Lindvall +1 more
TL;DR: In animal models, immature neural precursors can replace lost neurons, restore function and promote brain self-repair and clinical trials in Parkinson's disease suggest that similar approaches may also work in the diseased human brain.