A
Anders Björklund
Researcher at Lund University
Publications - 771
Citations - 87172
Anders Björklund is an academic researcher from Lund University. The author has contributed to research in topics: Transplantation & Dopamine. The author has an hindex of 165, co-authored 769 publications receiving 84268 citations. Previous affiliations of Anders Björklund include University of Washington & Institute for the Study of Labor.
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Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test
TL;DR: The experiments reported here evaluate the usefulness of a new “stepping test” to monitor forelimb akinesia in rats with unilateral 6-hydroxydopamine lesions of the mesencephalic dopamine (DA) system, and assess the ability of DA- receptor agonists and fetal DA neuron transplants to reverse these deficits.
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Site-Specific Migration and Neuronal Differentiation of Human Neural Progenitor Cells after Transplantation in the Adult Rat Brain
Rosemary A. Fricker,Melissa K. Carpenter,Christian Winkler,Corinne Greco,Monte A. Gates,Monte A. Gates,Anders Björklund +6 more
TL;DR: The ability of the human neural progenitors to respond in vivo to guidance cues and signals that can direct their differentiation along multiple phenotypic pathways suggests that they can provide a powerful and virtually unlimited source of cells for experimental and clinical transplantation.
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TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
Mickael Decressac,Bengt Mattsson,Pia Weikop,Martin Lundblad,Johan Jakobsson,Anders Björklund +5 more
TL;DR: It is shown that neurodegenerative changes induced by α-synuclein in midbrain dopamine neurons in vivo can be blocked through activation of the autophagy-lysosome pathway, and TFEB is identified as a promising target for therapies aimed at neuroprotection and disease modification in Parkinson disease.
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Prospects for new restorative and neuroprotective treatments in Parkinson's disease
TL;DR: This new understanding of the pathogenesis of Parkinson's disease now offers novel prospects for therapy based on targeted neuroprotection of vulnerable neurons and effective strategies for their replacement.
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The glyoxylic acid fluorescence histochemical method: a detailed account of the methodology for the visualization of central catecholamine neurons.
Olle Lindvall,Anders Björklund +1 more
TL;DR: It is concluded that the catecholamine fluorophores can be identified and distinguished by microspectrofluorometry from those of other fluorogenic monoamines known to occur in the vertebrate brain.