Anders Björklund

TL;DR: It is demonstrated that the mature neostriatal tissue can support axonal growth and innervation from grafted fetal DA neurons even in the presence of a normal complement of endogenous DA fibers.

TL;DR: The results suggest that NGF, given as a single injection at the time of transplantation and axonal lesioning, did not alter the time sequence of events in the growth process but rather that it accelerated or potentiated the outgrowth of the new axonal sprouts during the time when it normally occurred.

TL;DR: How far the clinical translation of the DA neuron replacement strategy has advanced is described and the attempts to generateDA neurons from stem cells of various sources and patient-specific DA neurons from fully differentiated somatic cells are summarized, with particular emphasis on the requirements of these cells to be useful in the clinical setting.

TL;DR: It is suggested that the addition of embryonic striatal target cells can exert stimulatory effects on morphological development, and possibly functional parameters, of fetal dopamine cells also in vivo after intrastriatal grafting.

TL;DR: Results show that long-term supply of NGF from ex vivo transduced, clonal NGF-secreting immortalized neural progenitor cells locally within the nucleus basalis and septum can prevent the subsequent development of age-dependent neuronal atrophy and behavioral impairments when the animals reach advanced age.