A
Anderson B. Guimarães-Costa
Researcher at National Institutes of Health
Publications - 22
Citations - 1751
Anderson B. Guimarães-Costa is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Neutrophil extracellular traps & Leishmania. The author has an hindex of 15, co-authored 21 publications receiving 1434 citations. Previous affiliations of Anderson B. Guimarães-Costa include Federal University of Rio de Janeiro.
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Journal ArticleDOI
Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps
Anderson B. Guimarães-Costa,Michelle T. C. Nascimento,Giselle Silva Froment,Rodrigo Pedro Soares,Fernanda Nazaré Morgado,Fátima Conceição-Silva,Elvira M. Saraiva +6 more
TL;DR: This work investigated the release of NETs by human neutrophils upon their interaction with Leishmania parasites and NETs' ability to kill this protozoan and found an innate response that might contribute to diminish parasite burden in the Leishmaniasis inoculation site.
Journal ArticleDOI
Classical ROS-dependent and early/rapid ROS-independent release of Neutrophil Extracellular Traps triggered by Leishmania parasites
Natalia C. Rochael,Anderson B. Guimarães-Costa,Anderson B. Guimarães-Costa,Michelle T. C. Nascimento,Thiago DeSouza-Vieira,Matheus P. Oliveira,Luiz F. Garcia e Souza,Marcus F. Oliveira,Elvira M. Saraiva +8 more
TL;DR: It is demonstrated that promastigotes induce a classical netosis, dependent on the cellular redox imbalance, as well as by a chloroamidine sensitive and elastase activity mechanism, which could support the development of new potential therapeutic strategies for leishmaniasis.
Journal ArticleDOI
ETosis: A Microbicidal Mechanism beyond Cell Death.
Anderson B. Guimarães-Costa,Michelle T. C. Nascimento,Amanda Brito Wardini,Lucia H. Pinto-da-Silva,Elvira M. Saraiva +4 more
TL;DR: The mechanism of NETosis/etosis is reviewed, emphasizing its role in diseases caused by protozoan parasites, fungi, and viruses.
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Gut Microbes Egested during Bites of Infected Sand Flies Augment Severity of Leishmaniasis via Inflammasome-Derived IL-1β
Ranadhir Dey,Amritanshu B. Joshi,Fabiano Oliveira,Lais Pereira,Lais Pereira,Anderson B. Guimarães-Costa,Tiago D. Serafim,Waldionê de Castro,Iliano V. Coutinho-Abreu,Parna Bhattacharya,Shannon Townsend,Hamide Aslan,Alec Perkins,Subir Karmakar,Nevien Ismail,Morgan Karetnick,Claudio Meneses,Robert Duncan,Hira L. Nakhasi,Jesus G. Valenzuela,Shaden Kamhawi +20 more
TL;DR: It is demonstrated that gut microbes from the sand fly are egested into host skin alongside Leishmania parasites, indicating that both gut microbiota and IL-1β are important for the establishment of Leishmaniasis infections.
Journal ArticleDOI
A Metabolic Shift toward Pentose Phosphate Pathway Is Necessary for Amyloid Fibril- and Phorbol 12-Myristate 13-Acetate-induced Neutrophil Extracellular Trap (NET) Formation
Estefania P. Azevedo,Natalia C. Rochael,Anderson B. Guimarães-Costa,Thiago S. de Souza-Vieira,Juliana Ganilho,Elvira M. Saraiva,Fernando L. Palhano,Debora Foguel +7 more
TL;DR: It is demonstrated that a metabolic shift toward the pentose phosphate pathway (PPP) is necessary for NET release because glucose-6-phosphate dehydrogenase (G6PD), an important enzyme from PPP, fuels NADPH oxidase with NADPH to produce superoxide and thus induce NETs.