Andi Dian Permana

TL;DR: This delivery approach could maximize the drugs concentrations in the lymph system without essentially increasing their plasma concentrations, and potentially deliver the drugs efficiently to the bloodstream, where the microfilariae reside, while also targeting drug to the lymph nodes, where filarial nematodes reside in infected patients, leading to an effective therapy for lymphatic filariasis.

TL;DR: The concept that the incorporation of ITZ-NCs into dissolving MNs can offer an effective approach for cutaneous candidiasis treatment is verified, and the antifungal activity in anex vivocandidiasis infection model exhibited that the CA viability declined by up to 100% after 48 h of administration.

TL;DR: The methotrexate nanocrystals were developed for its localising and sustaining its release in at the application site in the skin compared to conventional oral route and incorporated into dissolving microneedles for intradermal delivery.

TL;DR: In vitro dissolution studies in 10% w/v Tween 80 showed that the CU-NS dissolved significantly faster than unmodified curcumin powder, with 34% released from theCU-NS, compared to 16% from the cur cumin powder after 48 h.

TL;DR: The results presented here serve as proof of concept for the significant enhancement of drug retention times in the dermis, following their formulation into NS and delivery via MN.