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Andrea C. Haynes
Researcher at GlaxoSmithKline
Publications - 22
Citations - 7585
Andrea C. Haynes is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 16, co-authored 21 publications receiving 7010 citations.
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Journal ArticleDOI
Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
Takeshi Sakurai,Akira Amemiya,Makoto Ishii,Ichiyo Matsuzaki,Richard M. Chemelli,Hirokazu Tanaka,S. Clay Williams,James A. Richardson,Gerald P. Kozlowski,Shelagh Wilson,Jonathan R.S. Arch,Robin E. Buckingham,Andrea C. Haynes,Steven A. Carr,Roland S. Annan,Dean E. McNulty,Wu Schyong Liu,Jonathan A. Terrett,Nabil Elshourbagy,Derk J. Bergsma,Masashi Yanagisawa +20 more
TL;DR: Two novel neuropeptides are identified, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors in the hypothalamus of rats.
Journal ArticleDOI
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
John C. Clapham,Jonathan R.S. Arch,Helen Chapman,Andrea C. Haynes,Carolyn A. Lister,Gary B.T. Moore,Valerie Piercy,Sabrina A. Carter,Ines Lehner,Stephen A. Smith,Lee James Beeley,Robert James Godden,Nicole Herrity,Mark Skehel,Kumar Changani,Paul D. Hockings,David G. Reid,Sarah M. Squires,Jonathan P. Hatcher,Brenda K. Trail,Judy Latcham,Sohaila Rastan,Alexander J. Harper,Susana Cadenas,Julie A. Buckingham,Martin D. Brand,Alejandro Abuin +26 more
TL;DR: Evidence is provided that skeletal muscle UCP-3 has the potential to influence metabolic rate and glucose homeostasis in the whole animal by the creation of transgenic mice that overexpress human U CP-3 in skeletal muscle.
Journal ArticleDOI
Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat
Andrea C. Haynes,Brian A. Jackson,Phil Overend,Robin E. Buckingham,Shelagh Wilson,Mohammad Tadayyon,Jonathan R.S. Arch +6 more
TL;DR: Results demonstrate a circadian variation in feeding responses to orexin-A and an 8-day intracerebroventricular infusion with orexIn-A increased daytime feeding on days 2 and 8, but nocturnal feeding was reduced and there was no change in 24 h intake.
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A selective orexin-1 receptor antagonist reduces food consumption in male and female rats.
Andrea C. Haynes,Brian A. Jackson,Helen Chapman,Mohammed Tadayyon,Amanda Johns,Roderick A. Porter,Jonathan R.S. Arch +6 more
TL;DR: The suppression of nocturnal feeding and food intake stimulated by an overnight fast supports other evidence that orexin-A is involved in the regulation of natural feeding and suggests that oxin-1 receptor antagonists could be useful in the treatment of obesity.
Journal ArticleDOI
Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains
Olivier Mirguet,Romain Luc Marie Gosmini,Jérôme Toum,Catherine A. Clément,Mélanie Barnathan,Jean-Marie Brusq,Jacqueline Elizabeth Mordaunt,Grimes Richard Martin,Miriam Crowe,Olivier Pineau,Myriam Ajakane,Alain Claude-Marie Daugan,Phillip Jeffrey,Leanne Cutler,Andrea C. Haynes,Nicholas Smithers,Chun-wa Chung,Paul Bamborough,Iain Uings,Antonia J. Lewis,Jason Witherington,Nigel J. Parr,Rab K. Prinjha,Edwige Nicodeme +23 more
TL;DR: This work has yielded a potent, selective compound I-BET762 that is now under evaluation in a phase I/II clinical trial for nuclear protein in testis (NUT) midline carcinoma and other cancers.