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Andrea G. Nackley
Researcher at Duke University
Publications - 74
Citations - 6183
Andrea G. Nackley is an academic researcher from Duke University. The author has contributed to research in topics: Chronic pain & Catechol-O-methyl transferase. The author has an hindex of 30, co-authored 62 publications receiving 5223 citations. Previous affiliations of Andrea G. Nackley include University of Georgia & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Genetic basis for individual variations in pain perception and the development of a chronic pain condition
Luda Diatchenko,Gary D. Slade,Andrea G. Nackley,Konakporn Bhalang,Asgeir Sigurdsson,Inna Belfer,David Goldman,Ke Xu,Svetlana A. Shabalina,Dmitry A. Shagin,Mitchell B. Max,Sergei S. Makarov,William Maixner +12 more
TL;DR: Three genetic variants of the gene encoding catecholamine-O-methyltransferase determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD.
Journal ArticleDOI
Human Catechol-O-Methyltransferase Haplotypes Modulate Protein Expression by Altering mRNA Secondary Structure
Andrea G. Nackley,Svetlana A. Shabalina,Inna E. Tchivileva,K. Satterfield,O. Korchynskyi,Sergei S. Makarov,William Maixner,Luda Diatchenko +7 more
TL;DR: The major COMT haplotypes varied with respect to messenger RNA local stem-loop structures, such that the most stable structure was associated with the lowest protein levels and enzymatic activity.
Journal ArticleDOI
Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
TL;DR: Neuroinflammation drives widespread chronic pain via central sensitization and sex-dependent glial/immune signaling in chronic pain and new therapeutic approaches that control neuroinflammation for the resolution of chronic pain are discussed.
Journal ArticleDOI
Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
Luda Diatchenko,Andrea G. Nackley,Gary D. Slade,Kanokporn Bhalang,Inna Belfer,Mitchell B. Max,David Goldman,William Maixner +7 more
TL;DR: A mechanism whereby these two genetic polymorphisms differentially affect pain perception is proposed, which suggests that other SNPs of the COMT haplotype exert a greater influence on resting nociceptive sensitivity.
Journal ArticleDOI
Idiopathic pain disorders--pathways of vulnerability.
TL;DR: Idiopathic pain disorders consist of such conditions as temporomandibular joint disorders (TMJD), fibromyalgia syndrome (FMS), irritable bowel syndrome (IBS), chronic headaches, interstitial cystitis, chronic pelvic pain, chronic tinnitus, whiplash-associated disorders, and vulvar vestibulitis.