Andrea Mazzanti

Bio: Andrea Mazzanti is an academic researcher from University of Pavia. The author has contributed to research in topics: CMOS & Enantioselective synthesis. The author has an hindex of 52, co-authored 439 publications receiving 11646 citations. Previous affiliations of Andrea Mazzanti include University of Barcelona & Sigma-Tau.

2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC)Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC).

Abstract: ACC : American College of Cardiology ACE : angiotensin-converting enzyme ACS : acute coronary syndrome AF : atrial fibrillation AGNES : Arrhythmia Genetics in the Netherlands AHA : American Heart Association AMIOVIRT : AMIOdarone Versus Implantable cardioverter-defibrillator:

Class-C Harmonic CMOS VCOs, With a General Result on Phase Noise

Abstract: A harmonic oscillator topology displaying an improved phase noise performance is introduced in this paper. Exploiting the advantages yielded by operating the core transistors in class-C, a theoretical 3.9 dB phase noise improvement compared to the standard differential-pair LC-tank oscillator is achieved for the same current consumption. Further benefits derive from the natural rejection of the tail bias current noise, and from the absence of parasitic nodes sensitive to stray capacitances. Closed-form phase-noise equations obtained from a rigorous time-variant circuit analysis are presented, as well as a time-variant study of the stability of the oscillation amplitude, resulting in simple guidelines for a reliable design. Furthermore, the analysis of phase noise is extended to encompass a general harmonic oscillator, showing that all phase noise relations previously obtained for specific LC oscillator topologies are special cases of a very general and remarkably simple result.

Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

Abstract: The structural complexity and well-defined three-dimensional architecture of natural molecules are generally correlated with specificity of action and potentially useful biological properties. This complexity has inspired generations of synthetic chemists to design novel enantioselective strategies for assembling challenging target structures and reproducing the rich structural diversity inherent in natural molecules. This symbiotic correlation between natural compounds synthesis and the discovery of effective asymmetric—generally catalytic—technologies lies at the heart of the synthetic chemistry innovation. Despite the substantial advances made thus far, the construction of highly strained polycyclic structures (particularly those that contain spiro-stereocenters) and the generation of all-carbon quaternary stereocenters still remain daunting targets for synthesis. The spirocyclic oxindole core is featured in a number of natural products as well as medicinally relevant compounds (Figure 1), but its stereocontrolled synthesis, particularly installing the challenging spiro-quaternary stereocenter, poses a great synthetic problem. Only a few venerable asymmetric transformations, such as cycloaddition processes or the intramolecular Heck reaction, have proven suitable for achieving this challenging goal. Herein we show that asymmetric organocascade catalysis, which exploits the ability of chiral amines to efficiently combine two modes of catalyst activation of carbonyl compounds (iminium and enamine catalysis) into one mechanism, allows the direct, one-step synthesis of complex spirooxindolic cyclohexane derivatives; these products have three or four stereogenic carbon atoms and are obtained with extraordinary levels of stereocontrol starting from simple precursors. Specifically, we developed complementary organocatalytic multicomponent domino reactions based on two distinct organocatalysts, A and B, which efficiently activate carbonyl compounds such as ketones and aldehydes, respectively, toward multiple asymmetric transformations in a welldefined cascade sequence. Both strategies provide straightforward access to natural product inspired compound collections, which would be difficult to synthesize by other enantioselective methods.

Analysis and design of injection-locked LC dividers for quadrature generation

Abstract: Injection-locked LC dividers for low-power quadrature generation are discussed in this paper Modeling the circuits as regenerative frequency dividers leads to very simple analytical expressions for the locking band, phase deviation from quadrature and phase noise Maximizing the ratio between the injected and the biasing current is beneficial to all the above parameters whereas reducing the tank quality factor improves locking band and quadrature accuracy, though at the expense of current consumption, for given output amplitude To validate the theory, experiments have been carried on a 018-/spl mu/m CMOS direct conversion IC, embedding an injection-locked quadrature generator, realized for the Universal Mobile Telecommunication System Frequency locking range as large as 24% and phase deviation from quadrature around 08/spl deg/ are measured while each divider consumes 2 mA The phase noise of the quadrature generator is determined by the driving oscillator phase noise because the dividers contribution is easily made negligible up to hundreds of megahertz offset

2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC).

Abstract: 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC)

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Abstract: The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC Endorsed by the European Stroke Organisation (ESO)

2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD

Abstract: This is the second iteration of the European Society of Cardiology (ESC) and European Association for the Study of Diabetes (EASD) joining forces to write guidelines on the management of diabetes mellitus (DM), pre-diabetes, and cardiovascular disease (CVD), designed to assist clinicians and other healthcare workers to make evidence-based management decisions. The growing awareness of the strong biological relationship between DM and CVD rightly prompted these two large organizations to collaborate to generate guidelines relevant to their joint interests, the first of which were published in 2007. Some assert that too many guidelines are being produced but, in this burgeoning field, five years in the development of both basic and clinical science is a long time and major trials have reported in this period, making it necessary to update the previous Guidelines.

The somatic genomic landscape of glioblastoma

Abstract: We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated genes as well as complex rearrangements of signature receptors, including EGFR and PDGFRA. TERT promoter mutations are shown to correlate with elevated mRNA expression, supporting a role in telomerase reactivation. Correlative analyses confirm that the survival advantage of the proneural subtype is conferred by the G-CIMP phenotype, and MGMT DNA methylation may be a predictive biomarker for treatment response only in classical subtype GBM. Integrative analysis of genomic and proteomic profiles challenges the notion of therapeutic inhibition of a pathway as an alternative to inhibition of the target itself. These data will facilitate the discovery of therapeutic and diagnostic target candidates, the validation of research and clinical observations and the generation of unanticipated hypotheses that can advance our molecular understanding of this lethal cancer.