A
Andrea Pavirani
Researcher at Transgene SA
Publications - 104
Citations - 8384
Andrea Pavirani is an academic researcher from Transgene SA. The author has contributed to research in topics: Cystic fibrosis transmembrane conductance regulator & Genetic enhancement. The author has an hindex of 39, co-authored 104 publications receiving 8283 citations. Previous affiliations of Andrea Pavirani include Institut Gustave Roussy.
Papers
More filters
Journal ArticleDOI
In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium
Melissa A. Rosenfeld,Kunihiko Yoshimura,Bruce C. Trapnell,Koichi Yoneyama,Eugene Rosenthal,Wilfried Dalemans,Masashi Fukayama,Joachim Bargon,L Stier,Leslie Stratford-Perricaudet,Michel Perricaudet,William B. Guggino,Andrea Pavirani,J P Lecocq,Ronald G. Crystal +14 more
TL;DR: Observations suggest the feasibility of in vivo CFTR gene transfer as therapy for the pulmonary manifestations of CF.
Journal ArticleDOI
Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo
Melissa A. Rosenfeld,Wolfgang Siegfried,Kunihiko Yoshimura,Koichi Yoneyama,Masashi Fukayama,L Stier,Paavo K. Paakko,Pascale Gilardi,L D Stratford-Perricaudet,Michel Perricaudet,Sophie Jallat,Andrea Pavirani,Jean-Pierre Lecocq,Ronald G. Crystal +13 more
TL;DR: The respiratory epithelium is a potential site for somatic gene therapy for the common hereditary disorders alpha 1-antitrypsin (alpha 1AT) deficiency and cystic fibrosis by infecting epithelial cells of the cotton rat respiratory tract in vitro and in vivo.
Journal ArticleDOI
Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli.
TL;DR: A novel system based on the cloning and manipulation of the full-length adenovirus genome as a stable plasmid in E. coli, by using the bacterial homologous recombination machinery is described.
Journal ArticleDOI
Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation.
Wilfried Dalemans,Pascal Barbry,Guy Champigny,Sophie Jallat,Karin Dott,Dominique Dreyer,Ronald G. Crystal,Andrea Pavirani,Jean-Pierre Lecocq,Michel Lazdunski +9 more
TL;DR: The ΔF508 mutation seems to have two major consequences, an abnormal translocation of the CFTR protein which limits membrane insertion, and an abnormal function in mediating Cl- transport.
Journal ArticleDOI
cDNA cloning and expression of a hamster α‐thrombin receptor coupled to Ca2+ mobilization
Ulla B. Rasmussen,Valérie Vouret-Craviari,Sophie Jallat,Yasmin Schlesinger,Gilles Pagès,Andrea Pavirani,Jean-Pierre Lecocq,Jacques Pouysségur,Ellen Van Obberghen-Schilling +8 more
TL;DR: To clone a thrombin receptor cDNA, selective amplification of mRNA sequences displaying homology to the transmembrane domains of G‐protein‐coupled receptor genes was performed by polymerase chain reaction.