Andrea T. Da Poian

TL;DR: It is proposed that lipid droplets play multiple roles during the viral life cycle; they could sequester the viral capsid protein early during infection and provide a scaffold for genome encapsidation and a link between lipid droplet metabolism and viral replication is suggested.

TL;DR: Investigation of interleukin (IL)-1β synthesis, processing, and secretion in platelets during dengue virus (DV) infection and potential contribution of these events to endothelial permeability during infection finds that platelets contribute to increased vascular permeability in DV infection by inflammasome-dependent release of IL-1β.

TL;DR: This review integrated the structural rearrangements of each viral protein and their functions in all the steps of virus entry into the host cells, and the role of low pH-induced conformational changes in the envelope protein that mediate membrane fusion is discussed.

TL;DR: The results suggest that the combined action of 3-BrPA on succinate dehydrogenase and on glycolysis, inhibiting steps downstream of the phosphorylation of glucose, play an important role in HepG2 cell death.

TL;DR: New findings have recently emerged on the use of hydrostatic pressure to assess intermediate states in the assembly pathways of viruses, multimeric proteins and protein-nucleic acid complexes, addressing many questions of macromolecular recognition.