scispace - formally typeset
Search or ask a question
Author

Andrea Vasas

Bio: Andrea Vasas is an academic researcher from University of Szeged. The author has contributed to research in topics: Phenanthrenes & Diterpene. The author has an hindex of 24, co-authored 88 publications receiving 1899 citations. Previous affiliations of Andrea Vasas include Albert Szent-Györgyi Medical University.


Papers
More filters
Journal ArticleDOI
TL;DR: The present study furnishes an overview of the hydroxy or/and methoxy-substituted 9,10-dihydro/phenanthrene, methylated, prenylated and other monomeric derivatives, dimeric and trimeric phenanthrenes and their biological activities.

282 citations

Journal ArticleDOI
TL;DR: It is confirmed that some Rumex species have emerged as a good source of the traditional medicine for treatment of inflammation, cancer and different bacterial infections and provides new insights for further promising investigations on isolated compounds.

152 citations

Journal ArticleDOI
TL;DR: An overview of the chemical and pharmacological potential of European Euphorbia species is provided and the main aspects of the development of ingenol 3-angelate as a drug, screening methods, isolation strategies, the chemical characteristics of Euphorbiaceae diterpenes and the results of pharmacological investigations are surveyed.

101 citations

Journal ArticleDOI
TL;DR: Almost all of the newly isolated phenanthrenes that have been isolated between 2008 and 2016 showed multiple activities, and denbinobin, with a novel mechanism of action, has great potential as a lead compound for the development of a new anticancer agent.
Abstract: Although phenanthrenes are considered to constitute a relatively small group of natural products, discovering new phenanthrene derivatives and evaluating their prospective biological activities have become of great interest to many research groups worldwide. Based on 160 references, this review covers the phytochemistry and pharmacology of 213 naturally occurring phenanthrenes that have been isolated between 2008 and 2016. More than 40% of the 450 currently known naturally occurring phenanthrenes were identified during this period. The family Orchidaceae is the most abundant source of these compounds, although several new plant families and genera have been involved in the search for phenanthrenes. The presence of certain substituent patterns may be restricted to specific families; vinyl-substituted phenanthrenes were reported only from Juncaceae plants, and prenylated derivatives occur mainly in Euphorbiaceae species. Therefore, these compounds also can serve as chemotaxonomic markers. Almost all of the ...

86 citations


Cited by
More filters
Journal ArticleDOI
TL;DR: This review aims at highlighting photochemical transformations as a tool for rapidly accessing structurally and stereochemically diverse scaffolds for complex polycyclic carbon skeletons with impressive efficiency, which are of high value in total synthesis.
Abstract: The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the involvement of electronically excited states, generated upon absorption of photons. This produces transient reactive intermediates and significantly alters the reactivity of a chemical compound. The input of energy provided by light thus offers a means to produce strained and unique target compounds that cannot be assembled using thermal protocols. This review aims at highlighting photochemical transformations as a tool for rapidly accessing structurally and stereochemically diverse scaffolds. Synthetic designs based on photochemical transformations have the potential to afford complex polycyclic carbon skeletons with impressive efficiency, which are of high value in total synthesis.

692 citations

Journal ArticleDOI
TL;DR: The applications of gold catalysed reactions in total synthesis during the years since the last article are reviewed and literature analysis is conducted to evaluate the progress in this field.
Abstract: In this critical review the applications of gold catalysed reactions in total synthesis during the years since our last article are reviewed. At the end of this article a literature analysis is conducted to evaluate the progress in this field.

617 citations

Journal ArticleDOI
TL;DR: A brief discussion on P-gp mediated drug transport and how it hinders the success of various therapies and various strategies used to tackle this curb in the field of drug delivery and targeting are discussed.
Abstract: P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the body and is responsible for limiting cellular uptake and the distribution of xenobiotics and toxic substances. Hundreds of structurally diverse therapeutic agents are substrates to it and it impedes the absorption, permeability, and retention of the drugs, extruding them out of the cells. It is overexpressed in cancer cells and accountable for obstructing cell internalization of chemotherapeutic agents and for developing transporter mediated resistance by cancer cells during anti-tumor treatments. As it jeopardizes the success of drug delivery and cancer targeting, strategies are being developed to overcome P-gp mediated drug transport. This concise review represents a brief discussion on P-gp mediated drug transport and how it hinders the success of various therapies. Its main focus is on various strategies used to tackle this curb in the field of drug delivery and targeting.

467 citations

Journal ArticleDOI
TL;DR: The results confirmed the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds.
Abstract: 3.1. Biosynthesis from Jatrophanes 4313 3.2. Biosynthesis from Lathyranes 4314 4. Biological Activity 4314 4.1. Antiproliferative Activity 4314 4.2. Cytotoxicity 4316 4.3. Effects on the Cell Division 4316 4.4. DNA-Damaging Activity 4316 4.5. Modulatority of Multidrug Resistance 4316 4.6. Tumor Promoting Activity 4318 4.7. Pro-Inflammatory Activity 4318 4.8. Inhibition of Allergic Reactions 4318 4.9. Antimicrobial Activity 4319 4.10. Antidiarrheal Activity 4322 4.11. Antipyretic-Analgesic Activity 4322 4.12. Molluscicidal and Antifeedant Activities 4323 4.13. Inhibitory Activity on the Mammalian Mitochondrial Respiratory Chain 4323

402 citations

Journal ArticleDOI
TL;DR: This consensus statement presents a comprehensive and evidence-based set of guidelines for the care of postoperative nausea and vomiting (PONV) in both adult and pediatric populations based on a comprehensive search and review of literature up to September 2019.
Abstract: This consensus statement presents a comprehensive and evidence-based set of guidelines for the care of postoperative nausea and vomiting (PONV) in both adult and pediatric populations. The guidelines are established by an international panel of experts under the auspices of the American Society of Enhanced Recovery and Society for Ambulatory Anesthesia based on a comprehensive search and review of literature up to September 2019. The guidelines provide recommendation on identifying high-risk patients, managing baseline PONV risks, choices for prophylaxis, and rescue treatment of PONV as well as recommendations for the institutional implementation of a PONV protocol. In addition, the current guidelines focus on the evidence for newer drugs (eg, second-generation 5-hydroxytryptamine 3 [5-HT3] receptor antagonists, neurokinin 1 (NK1) receptor antagonists, and dopamine antagonists), discussion regarding the use of general multimodal PONV prophylaxis, and PONV management as part of enhanced recovery pathways. This set of guidelines have been endorsed by 23 professional societies and organizations from different disciplines (Appendix 1).Guidelines currently available include the 3 iterations of the consensus guideline we previously published, which was last updated 6 years ago; a guideline published by American Society of Health System Pharmacists in 1999; a brief discussion on PONV management as part of a comprehensive postoperative care guidelines; focused guidelines published by the Society of Obstetricians and Gynecologists of Canada, the Association of Paediatric Anaesthetists of Great Britain & Ireland and the Association of Perianesthesia Nursing; and several guidelines published in other languages.The current guideline was developed to provide perioperative practitioners with a comprehensive and up-to-date, evidence-based guidance on the risk stratification, prevention, and treatment of PONV in both adults and children. The guideline also provides guidance on the management of PONV within enhanced recovery pathways.The previous consensus guideline was published 6 years ago with a literature search updated to October 2011. Several guidelines, which have been published since, are either limited to a specific populations or do not address all aspects of PONV management. The current guideline was developed based on a systematic review of the literature published up through September 2019. This includes recent studies of newer pharmacological agents such as the second-generation 5-hydroxytryptamine 3 (5-HT3) receptor antagonists, a dopamine antagonist, neurokinin 1 (NK1) receptor antagonists as well as several novel combination therapies. In addition, it also contains an evidence-based discussion on the management of PONV in enhanced recovery pathways. We have also discussed the implementation of a general multimodal PONV prophylaxis in all at-risk surgical patients based on the consensus of the expert panel.

399 citations