A
Andrea Z. LaCroix
Researcher at University of California, San Diego
Publications - 284
Citations - 14392
Andrea Z. LaCroix is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Women's Health Initiative & Medicine. The author has an hindex of 44, co-authored 239 publications receiving 12081 citations. Previous affiliations of Andrea Z. LaCroix include University of California, Berkeley & Group Health Research Institute.
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Journal ArticleDOI
Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial
Garnet L. Anderson,Marian C. Limacher,Annlouise R. Assaf,Tamsen Bassford,Shirley A.A. Beresford,Henry R. Black,Denise E. Bonds,Robert L. Brunner,Robert G. Brzyski,Bette J. Caan,Rowan T. Chlebowski,J. David Curb,Margery Gass,Jennifer Hays,Gerardo Heiss,Susan L. Hendrix,Barbara V. Howard,Judith Hsia,F. Allan Hubbell,Rebecca D. Jackson,Karen C. Johnson,Howard L. Judd,Jane Morley Kotchen,Lewis H. Kuller,Andrea Z. LaCroix,Dorothy S. Lane,Robert Langer,Norman L. Lasser,Cora E. Lewis,JoAnn E. Manson,Karen L. Margolis,Judith K. Ockene,Mary Jo O'Sullivan,Lawrence S. Phillips,Ross L. Prentice,Cheryl Ritenbaugh,John A Robbins,Jacques E. Rossouw,Gloria E. Sarto,Marcia L. Stefanick,Linda Van Horn,Jean Wactawski-Wende,Robert B. Wallace,Sylvia Wassertheil-Smoller +43 more
TL;DR: The use of conjugated equine estrogen (CEE) increases the risk of stroke, decreases therisk of hip fracture, and does not affect CHD incidence in postmenopausal women with prior hysterectomy over an average of 6.8 years, indicating no overall benefit.
Journal ArticleDOI
DNA methylation-based measures of biological age: meta-analysis predicting time to death
Brian H. Chen,Riccardo E. Marioni,Riccardo E. Marioni,Elena Colicino,Marjolein J. Peters,Cavin K. Ward-Caviness,Pei-Chien Tsai,Nicholas S. Roetker,Allan C. Just,Ellen W. Demerath,Weihua Guan,Jan Bressler,Myriam Fornage,Myriam Fornage,Stephanie A. Studenski,Amy R. Vandiver,Ann Zenobia Moore,Toshiko Tanaka,Douglas P. Kiel,Liming Liang,Pantel S. Vokonas,Joel Schwartz,Kathryn L. Lunetta,Kathryn L. Lunetta,Joanne M. Murabito,Joanne M. Murabito,Stefania Bandinelli,Dena G. Hernandez,David Melzer,Mike A. Nalls,Luke C. Pilling,Timothy Ryan Price,Andrew B. Singleton,Christian Gieger,Rolf Holle,Anja Kretschmer,Florian Kronenberg,Sonja Kunze,Jakob Linseisen,Christine Meisinger,Wolfgang Rathmann,Melanie Waldenberger,Peter M. Visscher,Peter M. Visscher,Sonia Shah,Naomi R. Wray,Allan F. McRae,Oscar H. Franco,Albert Hofman,Albert Hofman,André G. Uitterlinden,Devin Absher,Themistocles L. Assimes,Morgan E. Levine,Ake T. Lu,Philip S. Tsao,Philip S. Tsao,Lifang Hou,JoAnn E. Manson,Cara L. Carty,Andrea Z. LaCroix,Alexander P. Reiner,Alexander P. Reiner,Tim D. Spector,Andrew P. Feinberg,Daniel Levy,Andrea A. Baccarelli,Andrea A. Baccarelli,Joyce B. J. van Meurs,Jordana T. Bell,Annette Peters,Ian J. Deary,James S. Pankow,Luigi Ferrucci,Steve Horvath +74 more
TL;DR: Evidence that epigenetic age predicts all-cause mortality above and beyond chronological age and traditional risk factors is strengthened and estimates that incorporate information on blood cell counts lead to highly significant associations with all- Cause mortality are demonstrated.
Journal ArticleDOI
Older adults' views of "successful aging" how do they compare with researchers' definitions?
TL;DR: Whether older adults have thought about aging and aging successfully and to compare their perceptions of successful aging with attributes of successful Aging identified in the published literature are compared.
Detectable clonal mosaicism and its relationship to aging and cancer
Kevin B. Jacobs,Meredith Yeager,Weiyin Zhou,Sholom Wacholder,Zhaoming Wang,Benjamín Rodríguez-Santiago,Amy Hutchinson,Xiang Deng,Chenwei Liu,Marie-Josephe Horner,Michael Cullen,Caroline G. Epstein,Laurie Burdett,Michael Dean,Nilanjan Chatterjee,Joshua N. Sampson,Charles C. Chung,Joseph Kovaks,Susan M. Gapstur,Victoria L. Stevens,Lauren T. Teras,Mia M. Gaudet,Demetrius Albanes,Stephanie J. Weinstein,Jarmo Virtamo,Philip R. Taylor,Neal D. Freedman,Christian C. Abnet,Alisa M. Goldstein,Nan Hu,Kai Yu,Jian-Min Yuan,Linda M. Liao,Ti Ding,You-Lin Qiao,Yu Tang Gao,Woon-Puay Koh,Yong-Bing Xiang,Ze-Zhong Tang,Jin-Hu Fan,Melinda C. Aldrich,Christopher I. Amos,William J. Blot,Cathryn H. Bock,Elizabeth M. Gillanders,Curtis C. Harris,Christopher A. Haiman,Brian E. Henderson,Laurence N. Kolonel,Loic Le Marchand,Lorna H. McNeill,Benjamin A. Rybicki,Ann G. Schwartz,Lisa B. Signorello,Margaret R. Spitz,John K. Wiencke,Margaret Wrensch,Xifeng Wu,Krista A. Zanetti,Regina G. Ziegler,Jonine D. Figueroa,Montserrat Garcia-Closas,Núria Malats,Gaëlle Marenne,Ludmila Prokunina-Olsson,Dalsu Baris,Molly Schwenn,Alison Johnson,Maria Teresa Landi,Lynn R. Goldin,Dario Consonni,Pier Alberto Bertazzi,Melissa Rotunno,Preetha Rajaraman,Ulrika Andersson,Laura E. Beane Freeman,Christine D. Berg,Julie E. Buring,Mary Ann Butler,Tania Carreón,Maria Feychting,Anders Ahlbom,J. Michael Gaziano,Graham G. Giles,Göran Hallmans,Susan E. Hankinson,Patricia Hartge,Roger Henriksson,Peter D. Inskip,Christoffer Johansen,Annelie Landgren,Roberta McKean-Cowdin,Dominique S. Michaud,Beatrice Melin,Ulrike Peters,Avima M. Ruder,Howard D. Sesso,Gianluca Severi,Xiao-Ou Shu,Kala Visvanathan,Emily White,Alicja Wolk,Anne Zeleniuch-Jacquotte,Wei Zheng,Debra T. Silverman,Manolis Kogevinas,Juan R. González,Olaya Villa,Donghui Li,Eric J. Duell,Harvey A. Risch,Sara H. Olson,Charles Kooperberg,Brian M. Wolpin,Li Jiao,Manal M. Hassan,William Wheeler,Alan A. Arslan,H. Bas Bueno-de-Mesquita,Charles S. Fuchs,Steven Gallinger,Myron D. Gross,Elizabeth A. Holly,Alison P. Klein,Andrea Z. LaCroix,Margaret T. Mandelson,Gloria M. Petersen,Marie-Christine Boutron-Ruault,Paige M. Bracci,Federico Canzian,Kenneth J. Chang,Michelle Cotterchio,Edward Giovannucci,Michael Goggins,Judith A. Hoffman Bolton,Mazda Jenab,Kay-Tee Khaw,Vittorio Krogh,Robert C. Kurtz,Robert R. McWilliams,Julie B. Mendelsohn,Kari G. Rabe,Elio Riboli,Anne Tjønneland,Geoffrey S. Tobias,Dimitrios Trichopoulos,Joanne W. Elena,Herbert Yu,Laufey T. Amundadottir,Rachael Z. Stolzenberg-Solomon,Peter Kraft,Fredrick R. Schumacher,Daniel O. Stram,Sharon A. Savage,Lisa Mirabello,Irene L. Andrulis,Jay S. Wunder,Ana Patino Garcia,Luis Sierrasesúmaga,Donald A. Barkauskas,Richard Gorlick,Mark P. Purdue,Wong-Ho Chow,Lee E. Moore,Kendra Schwartz,Faith G. Davis,Ann W. Hsing,Sonja I. Berndt,Amanda Black,Nicolas Wentzensen,Louise A. Brinton,Jolanta Lissowska,Beata Peplonska,Katherine A. McGlynn,Michael B. Cook,Barry I. Graubard,Christian P. Kratz,Mark H. Greene,Ralph L. Erickson,David J. Hunter,Gilles Thomas,Robert N. Hoover,Francisco X. Real,Joseph F. Fraumeni,Neil E. Caporaso,Margaret A. Tucker,Nathaniel Rothman,Luis A. Pérez-Jurado,Stephen J. Chanock +188 more
TL;DR: Large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases.
Journal ArticleDOI
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.
Hou-Feng Zheng,Vincenzo Forgetta,Yi-Hsiang Hsu,Yi-Hsiang Hsu,Karol Estrada,Alberto Roselló-Díez,Paul Leo,Chitra Lekha Dahia,Chitra Lekha Dahia,Kyung-Hyun Park-Min,Jonathan H Tobias,Charles Kooperberg,Aaron Kleinman,Unnur Styrkarsdottir,Ching-Ti Liu,Charlotta Uggla,Daniel S. Evans,Carrie M. Nielson,Klaudia Walter,Ulrika Pettersson-Kymmer,Shane A. McCarthy,Joel Eriksson,Tony Kwan,Mila Jhamai,Katerina Trajanoska,Yasin Memari,J L Min,Jie Huang,Petr Danecek,Beth Wilmot,Rui Li,Wen-Chi Chou,Lauren E. Mokry,Alireza Moayyeri,Alireza Moayyeri,Melina Claussnitzer,Chia-Ho Cheng,Warren A. Cheung,Carolina Medina-Gomez,Bing Ge,Shu Huang Chen,Kwangbom Choi,Ling Oei,James Fraser,Robert Kraaij,Matthew A. Hibbs,Matthew A. Hibbs,Celia L Gregson,Denis Paquette,Albert Hofman,Carl Wibom,Gregory J. Tranah,Mhairi Marshall,Brooke Gardiner,Katie Cremin,Paul L. Auer,Li Hsu,Susan M. Ring,Joyce Y. Tung,Gudmar Thorleifsson,A.W. Enneman,Natasja M. van Schoor,Lisette C. P. G. M. de Groot,Nathalie van der Velde,Beatrice Melin,John P. Kemp,John P. Kemp,Claus Christiansen,Adrian Sayers,Yanhua Zhou,Sophie Calderari,Jeroen van Rooij,Christopher S. Carlson,Ulrike Peters,Soizik Berlivet,Josée Dostie,André G. Uitterlinden,Stephen R. Williams,Charles R. Farber,Daniel Grinberg,Andrea Z. LaCroix,Jeffrey Haessler,Daniel I. Chasman,Franco Giulianini,Lynda M. Rose,Paul M. Ridker,John A. Eisman,John A. Eisman,John A. Eisman,Tuan V. Nguyen,Tuan V. Nguyen,Xavier Nogués,Xavier Nogués,Natalia Garcia-Giralt,Lenore Launer,V. Gudnason,Dan Mellström,Liesbeth Vandenput,Najaf Amin,Cornelia M. van Duijn,Magnus Karlsson,Östen Ljunggren,Olle Svensson,Göran Hallmans,François Rousseau,Sylvie Giroux,Johanne Bussiere,Pascal P. Arp,Fjorda Koromani,Richard L. Prince,Richard L. Prince,Joshua R. Lewis,Joshua R. Lewis,Bente L. Langdahl,A. Pernille Hermann,Jens Erik Beck Jensen,Stephen Kaptoge,Kay-Tee Khaw,Jonathan Reeve,Jonathan Reeve,Melissa M. Formosa,Angela Xuereb-Anastasi,Kristina Åkesson,Fiona E. McGuigan,Gaurav Garg,José M. Olmos,María T. Zarrabeitia,José A. Riancho,Stuart H. Ralston,Nerea Alonso,Xi Jiang,David Goltzman,Tomi Pastinen,Elin Grundberg,Dominique Gauguier,Eric S. Orwoll,David Karasik,George Davey-Smith,Albert V. Smith,Kristin Siggeirsdottir,Tamara B. Harris,M. Carola Zillikens,Joyce B. J. van Meurs,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Matthew T. Maurano,Nicholas J. Timpson,Nicole Soranzo,Richard Durbin,Scott Wilson,Scott Wilson,Scott Wilson,Evangelia E. Ntzani,Evangelia E. Ntzani,Matthew A. Brown,Kari Stefansson,Kari Stefansson,David A. Hinds,Tim D. Spector,L. Adrienne Cupples,Claes Ohlsson,Celia M. T. Greenwood,Rebecca D. Jackson,David W. Rowe,Cynthia A. Loomis,David M. Evans,David M. Evans,Cheryl L. Ackert-Bicknell,Alexandra L. Joyner,Emma L. Duncan,Emma L. Duncan,Douglas P. Kiel,Fernando Rivadeneira,J. Brent Richards,J. Brent Richards +174 more
TL;DR: Evidence is provided that low‐frequency non‐coding variants have large effects on BMD and fracture, thereby providing rationale for whole‐genome sequencing and improved imputation reference panels to study the genetic architecture of complex traits and disease in the general population.