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Andreas G. Nerlich
Researcher at Ludwig Maximilian University of Munich
Publications - 411
Citations - 14738
Andreas G. Nerlich is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Basement membrane & Laminin. The author has an hindex of 58, co-authored 390 publications receiving 13831 citations. Previous affiliations of Andreas G. Nerlich include München Klinik Bogenhausen & University of Washington.
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Journal ArticleDOI
Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science.
Norbert Boos,Sabine Weissbach,Helmut Rohrbach,Christoph Weiler,Kevin F. Spratt,Andreas G. Nerlich +5 more
TL;DR: Histologic disc alterations can reliably be graded based on the proposed classification system providing a morphologic framework for more sophisticated molecular biologic analyses of factors leading to age-related disc changes.
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Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.
TL;DR: The strong dependence of C ML formation on oxidative conditions together with the increased occurrence of CML in diabetic serum and tissue proteins suggest a role for CML as endogenous biomarker for oxidative damage.
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Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy.
TL;DR: Findings indicate focal premature chondrocyte differentiation to hypertrophic cells in OA cartilage, which is consistent with the appearance of hypertrophic chondROcytes in osteoarthritic cartilage.
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High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells.
TL;DR: The study indicates that the flux of glucose metabolism through the GFAT catalyzed hexosamine biosynthetic pathway is involved in the glucose-induced mesangial production of TGF-beta leading to increased matrix production.
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Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls.
TL;DR: Its occurrence in adults of more advanced age suggests that tumor necrosis factor; is not involved in the initiation of disc degeneration, but may be associated with further promotion of degenerative disarrangement and pain induction.