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Andreas Lennartsson
Researcher at Karolinska Institutet
Publications - 65
Citations - 6995
Andreas Lennartsson is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 26, co-authored 60 publications receiving 5902 citations. Previous affiliations of Andreas Lennartsson include Lund University.
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Journal ArticleDOI
An atlas of active enhancers across human cell types and tissues
Robin Andersson,Claudia Gebhard,Irene Miguel-Escalada,Ilka Hoof,Jette Bornholdt,Mette Boyd,Yun Chen,Xiaobei Zhao,Xiaobei Zhao,Christian Schmidl,Takahiro Suzuki,Evgenia Ntini,Erik Arner,Eivind Valen,Eivind Valen,Kang Li,Lucia Schwarzfischer,Dagmar Glatz,Johanna Raithel,Berit Lilje,Nicolas Rapin,Frederik Otzen Bagger,Mette Rose Jørgensen,Peter Refsing Andersen,Nicolas Bertin,Owen J. L. Rackham,A. Maxwell Burroughs,J Kenneth Baillie,Yuri Ishizu,Yuri Shimizu,Erina Furuhata,Shiori Maeda,Yutaka Negishi,Christopher J. Mungall,Terrence F. Meehan,Timo Lassmann,Masayoshi Itoh,Hideya Kawaji,Naoto Kondo,Jun Kawai,Andreas Lennartsson,Carsten O. Daub,Peter Heutink,David A. Hume,Torben Heick Jensen,Harukazu Suzuki,Yoshihide Hayashizaki,Ferenc Müller,Alistair R. R. Forrest,Piero Carninci,Michael Rehli,Albin Sandelin +51 more
TL;DR: It is shown that enhancers share properties with CpG-poor messenger RNA promoters but produce bidirectional, exosome-sensitive, relatively short unspliced RNAs, the generation of which is strongly related to enhancer activity.
Journal ArticleDOI
A promoter-level mammalian expression atlas
Alistair R. R. Forrest,Hideya Kawaji,Michael Rehli,J Kenneth Baillie,Michiel J. L. de Hoon,Vanja Haberle,Vanja Haberle,Timo Lassmann,Ivan V. Kulakovskiy,Ivan V. Kulakovskiy,Marina Lizio,Masayoshi Itoh,Robin Andersson,Christopher J. Mungall,Terrence F. Meehan,Sebastian Schmeier,Sebastian Schmeier,Nicolas Bertin,Mette C. Jørgensen,Emmanuel Dimont,Erik Arner,Christian Schmidl,Christian Schmidl,Ulf Schaefer,Yulia A. Medvedeva,Yulia A. Medvedeva,Charles Plessy,Morana Vitezic,Jessica Severin,Colin A. Semple,Yuri Ishizu,Robert Young,Margherita Francescatto,Margherita Francescatto,Intikhab Alam Altschuler,Davide Albanese,Gabriel M. Altschule,Takahiro Arakawa,John A.C. Archer,Peter Arner,Magda Babina,Sarah Rennie,Piotr J. Balwierz,Anthony G Beckhouse,Swati Pradhan-Bhatt,Judith A. Blake,Antje Blumenthal,Beatrice Bodega,Alessandro Bonetti,James Briggs,James Briggs,Frank Brombacher,Frank Brombacher,A. Maxwell Burroughs,Andrea Califano,Carlo Vittorio Cannistraci,Carlo Vittorio Cannistraci,Daniel Carbajo,Yun Chen,Marco Chierici,Yari Ciani,Hans Clevers,Hans Clevers,Emiliano Dalla,Carrie A. Davis,Michael Detmar,Alexander D. Diehl,Taeko Dohi,Finn Drabløs,Albert S.B. Edge,Matthias Edinger,Karl Ekwall,Mitsuhiro Endoh,Hideki Enomoto,Michela Fagiolini,Lynsey Fairbairn,Hai Fang,Mary C. Farach-Carson,Geoffrey J. Faulkner,Alexander V. Favorov,Alexander V. Favorov,Alexander V. Favorov,Malcolm E. Fisher,Martin C. Frith,Rie Fujita,Shiro Fukuda,Cesare Furlanello,Masaaki Furuno,Jun Ichi Furusawa,Teunis B. H. Geijtenbeek,Andrew P. Gibson,Thomas R. Gingeras,Dan Goldowitz,Julian Gough,Sven Guhl,Reto Guler,Reto Guler,Stefano Gustincich,Thomas J. Ha,Masahide Hamaguchi,Mitsuko Hara,Matthias Harbers,Jayson Harshbarger,Akira Hasegawa,Yuki Hasegawa,Takehiro Hashimoto,Meenhard Herlyn,Kelly J Hitchens,Shannan J. Ho Sui,Oliver Hofmann,Ilka Hoof,Fumi Hori,Lukasz Huminiecki,Kei Iida,Tomokatsu Ikawa,Boris R. Jankovic,Hui Jia,Anagha Joshi,Giuseppe Jurman,Bogumil Kaczkowski,Chieko Kai,Kaoru Kaida,Ai Kaiho,Kazuhiro Kajiyama,Mutsumi Kanamori-Katayama,Artem S. Kasianov,Takeya Kasukawa,Shintaro Katayama,Sachi Kato,Shuji Kawaguchi,Hiroshi Kawamoto,Yuki I. Kawamura,Tsugumi Kawashima,Judith S. Kempfle,Tony J. Kenna,Juha Kere,Juha Kere,Levon M. Khachigian,Toshio Kitamura,S. Peter Klinken,Alan J. Knox,Miki Kojima,Soichi Kojima,Naoto Kondo,Haruhiko Koseki,Shigeo Koyasu,Sarah Krampitz,Atsutaka Kubosaki,Andrew T. Kwon,Jeroen F. J. Laros,Weon Ju Lee,Andreas Lennartsson,Kang Li,Berit Lilje,Leonard Lipovich,Alan Mackay-Sim,Ri Ichiroh Manabe,Jessica C. Mar,Benoit Marchand,Anthony Mathelier,Niklas Mejhert,Alison M. Meynert,Yosuke Mizuno,David A. de Lima Morais,Hiromasa Morikawa,Mitsuru Morimoto,Kazuyo Moro,Efthymios Motakis,Hozumi Motohashi,Christine L. Mummery,Mitsuyoshi Murata,Sayaka Nagao-Sato,Yutaka Nakachi,Fumio Nakahara,Toshiyuki Nakamura,Yukio Nakamura,Kenichi Nakazato,Erik van Nimwegen,Noriko Ninomiya,Hiromi Nishiyori,Shohei Noma,Tadasuke Nozaki,Soichi Ogishima,Soichi Ogishima,Naganari Ohkura,Hiroko Ohmiya,Hiroshi Ohno,Mitsuhiro Ohshima,Mariko Okada-Hatakeyama,Yasushi Okazaki,Valerio Orlando,Dmitry A. Ovchinnikov,Arnab Pain,Robert Passier,Margaret Patrikakis,Helena Persson,Silvano Piazza,James Prendergast,Owen J. L. Rackham,Jordan A. Ramilowski,Mamoon Rashid,Timothy Ravasi,Patrizia Rizzu,Marco Roncador,Sugata Roy,Morten Beck Rye,Eri Saijyo,Antti Sajantila,Akiko Saka,Shimon Sakaguchi,Mizuho Sakai,Hiroki Sato,Hironori Satoh,Suzana Savvi,Suzana Savvi,Alka Saxena,Claudio Schneider,Erik Anthony Schultes,Gundula G. Schulze-Tanzil,Anita Schwegmann,Anita Schwegmann,Thierry Sengstag,Guojun Sheng,Hisashi Shimoji,Yishai Shimoni,Jay W. Shin,Christophe Simon,Daisuke Sugiyama,Takaaki Sugiyama,Masanori Suzuki,Naoko Suzuki,Rolf Swoboda,Peter A C 't Hoen,Michihira Tagami,Naoko Takahashi Tagami,Jun Takai,Hiroshi Tanaka,Hideki Tatsukawa,Zuotian Tatum,Mark Thompson,Hiroo Toyoda,Tetsuro Toyoda,Eivind Valen,Marc van de Wetering,Linda M. van den Berg,Roberto Verardo,Dipti Vijayan,Ilya E. Vorontsov,Wyeth W. Wasserman,Shoko Watanabe,Christine A. Wells,Louise N. Winteringham,Ernst J. Wolvetang,Emily J. Wood,Yoko Yamaguchi,Masayuki Yamamoto,Misako Yoneda,Yohei Yonekura,Shigehiro Yoshida,Susan E. Zabierowski,Peter G. Zhang,Xiaobei Zhao,Silvia Zucchelli,Kim M. Summers,Harukazu Suzuki,Carsten O. Daub,Jun Kawai,Peter Heutink,Winston Hide,Tom C. Freeman,Boris Lenhard,Boris Lenhard,Lenhard Vladimir B. Bajic,Martin S. Taylor,Vsevolod J. Makeev,Vsevolod J. Makeev,Vsevolod J. Makeev,Albin Sandelin,David A. Hume,Piero Carninci,Yoshihide Hayashizaki +280 more
TL;DR: For example, the authors mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body.
Journal ArticleDOI
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells
Erik Arner,Carsten O. Daub,Kristoffer Vitting-Seerup,Robin Andersson,Berit Lilje,Finn Drabløs,Andreas Lennartsson,Michelle Rönnerblad,Olga Hrydziuszko,Morana Vitezic,Tom C. Freeman,Ahmad M. N. Alhendi,Peter Arner,Richard A Axton,J Kenneth Baillie,Anthony G Beckhouse,Beatrice Bodega,James Briggs,Frank Brombacher,Margaret B. Davis,Michael Detmar,Anna Ehrlund,Mitsuhiro Endoh,Afsaneh Eslami,Michela Fagiolini,Lynsey Fairbairn,Geoffrey J. Faulkner,Carmelo Ferrai,Malcolm E. Fisher,Lesley M. Forrester,Dan Goldowitz,Reto Guler,Thomas J. Ha,Mitsuko Hara,Meenhard Herlyn,Tomokatsu Ikawa,Chieko Kai,Hiroshi Kawamoto,Levon M. Khachigian,S. Peter Klinken,Soichi Kojima,Haruhiko Koseki,Sarah Klein,Niklas Mejhert,Ken Miyaguchi,Yosuke Mizuno,Mitsuru Morimoto,Kelly J. Morris,Christine L. Mummery,Yutaka Nakachi,Soichi Ogishima,Mariko Okada-Hatakeyama,Yasushi Okazaki,Valerio Orlando,Dmitry A. Ovchinnikov,Robert Passier,Margaret Patrikakis,Ana Pombo,Xian-Yang Qin,Sugata Roy,Hiroki Sato,Suzana Savvi,Alka Saxena,Anita Schwegmann,Daisuke Sugiyama,Rolf Swoboda,Hiroshi Tanaka,Andru Tomoiu,Louise N. Winteringham,Ernst J. Wolvetang,Chiyo Yanagi-Mizuochi,Misako Yoneda,Susan E. Zabierowski,Peter G. Zhang,Imad Abugessaisa,Nicolas Bertin,Alexander D. Diehl,Shiro Fukuda,Masaaki Furuno,Jayson Harshbarger,Akira Hasegawa,Fumi Hori,Sachi Ishikawa-Kato,Yuri Ishizu,Masayoshi Itoh,Tsugumi Kawashima,Miki Kojima,Naoto Kondo,Marina Lizio,Terrence F. Meehan,Christopher J. Mungall,Mitsuyoshi Murata,Hiromi Nishiyori-Sueki,Serkan Sahin,Sayaka Nagao-Sato,Jessica Severin,Michiel J. L. de Hoon,Jun Kawai,Takeya Kasukawa,Timo Lassmann,Harukazu Suzuki,Hideya Kawaji,Kim M. Summers,Christine A. Wells,David A. Hume,Alistair R. R. Forrest,Albin Sandelin,Piero Carninci,Yoshihide Hayashizaki +108 more
TL;DR: The data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during cellular differentiation or activation.
Journal ArticleDOI
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
Harukazu Suzuki,Alistair R. R. Forrest,Erik van Nimwegen,Carsten O. Daub,Piotr J. Balwierz,Katharine M. Irvine,Timo Lassmann,Timothy Ravasi,Yuki Hasegawa,Michiel J. L. de Hoon,Shintaro Katayama,Kate Schroder,Piero Carninci,Yasuhiro Tomaru,Mutsumi Kanamori-Katayama,Atsutaka Kubosaki,Altuna Akalin,Yoshinari Ando,Erik Arner,Maki Asada,Hiroshi Asahara,Timothy L. Bailey,Vladimir B. Bajic,Denis C. Bauer,Anthony G Beckhouse,Nicolas Bertin,Johan Björkegren,Frank Brombacher,Erika Bulger,Alistair M. Chalk,Joe Chiba,Nicole Cloonan,Adam Dawe,Josée Dostie,Pär G. Engström,Magbubah Essack,Geoffrey J. Faulkner,J. Lynn Fink,David Fredman,Ko Fujimori,Masaaki Furuno,Takashi Gojobori,Julian Gough,Sean M. Grimmond,Mika Gustafsson,Megumi Hashimoto,Takehiro Hashimoto,Mariko Hatakeyama,Susanne Heinzel,Winston Hide,Winston Hide,Oliver Hofmann,Oliver Hofmann,Michael Hörnquist,Lukasz Huminiecki,Kazuho Ikeo,Naoko Imamoto,Satoshi Inoue,Yusuke Inoue,Ryoko Ishihara,Takao Iwayanagi,Anders Jacobsen,Mandeep Kaur,Hideya Kawaji,Markus C. Kerr,Ryuichiro Kimura,Syuhei Kimura,Yasumasa Kimura,Hiroaki Kitano,Hisashi Koga,Toshio Kojima,Shinji Kondo,Takeshi Konno,Anders Krogh,Adele Kruger,Ajit Kumar,Boris Lenhard,Andreas Lennartsson,Morten Lindow,Marina Lizio,Cameron Ross MacPherson,Norihiro Maeda,Christopher G. Maher,Monique Maqungo,Jessica C. Mar,Nicholas Matigian,Hideo Matsuda,John S. Mattick,Stuart Meier,Sei Miyamoto,Etsuko Miyamoto-Sato,Kazuhiko Nakabayashi,Yutaka Nakachi,Mika Nakano,Sanne Nygaard,Toshitsugu Okayama,Yasushi Okazaki,Haruka Okuda-Yabukami,Valerio Orlando,Jun Otomo,Mikhail Pachkov,Nikolai Petrovsky,Charles Plessy,John Quackenbush,Aleksandar Radovanovic,Michael Rehli,Rintaro Saito,Albin Sandelin,Sebastian Schmeier,Christian Schönbach,Ariel S. Schwartz,Colin A. Semple,Miho Sera,Jessica Severin,Katsuhiko Shirahige,Cas Simons,Georges St. Laurent,Masanori Suzuki,Takahiro Suzuki,Matthew J. Sweet,Ryan J. Taft,Shizu Takeda,Yoichi Takenaka,Kai Tan,Martin S. Taylor,Rohan D. Teasdale,Jesper Tegnér,Jesper Tegnér,Sarah A. Teichmann,Eivind Valen,Claes Wahlestedt,Kazunori Waki,Andrew Waterhouse,Christine A. Wells,Ole Winther,Linda Wu,Kazumi Yamaguchi,Hiroshi Yanagawa,Jun Yasuda,Mihaela Zavolan,David A. Hume,Takahiro Arakawa,Shiro Fukuda,Kengo Imamura,Chikatoshi Kai,Ai Kaiho,Tsugumi Kawashima,Chika Kawazu,Yayoi Kitazume,Miki Kojima,Hisashi Miura,Kayoko Murakami,Mitsuyoshi Murata,Noriko Ninomiya,Hiromi Nishiyori,Shohei Noma,Chihiro Ogawa,Takuma Sano,Christophe Simon,Michihira Tagami,Yukari Takahashi,Jun Kawai,Yoshihide Hayashizaki +162 more
TL;DR: The results indicate that cellular states are constrained by complex networks involving both positive and negative regulatory interactions among substantial numbers of transcription factors and that no single transcription factor is both necessary and sufficient to drive the differentiation process.
Journal ArticleDOI
Histone modification patterns and epigenetic codes.
Andreas Lennartsson,Karl Ekwall +1 more
TL;DR: This review discusses the histone modification patterns found in genome-wide studies in different biological models and how they influence cell differentiation and carcinogenesis.