Author
Andreas Pfeiffer
Other affiliations: Heidelberg University, Paul Scherrer Institute, Université libre de Bruxelles ...read more
Bio: Andreas Pfeiffer is an academic researcher from CERN. The author has contributed to research in topics: Large Hadron Collider & Lepton. The author has an hindex of 149, co-authored 1756 publications receiving 131080 citations. Previous affiliations of Andreas Pfeiffer include Heidelberg University & Paul Scherrer Institute.
Topics: Large Hadron Collider, Lepton, Standard Model, Higgs boson, Boson
Papers published on a yearly basis
Papers
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Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1 +2156 more•Institutions (141)
TL;DR: A search for a standard model Higgs boson produced in association with a top-quark pair and decaying to bottom quarks is presented and the results are presented in terms of the measured signal strength modifier.
Abstract: A search for a standard model Higgs boson produced in association with a top-quark pair and decaying to bottom quarks is presented. Events with hadronic jets and one or two oppositely charged leptons are selected from a data sample corresponding to an integrated luminosity of 19.5 inverse femtobarns collected by the CMS experiment at the LHC in pp collisions at a centre-of-mass energy of 8 TeV. In order to separate the signal from the larger ttbar+jets background, this analysis uses a matrix element method that assigns a probability density value to each reconstructed event under signal or background hypotheses. The ratio between the two values is used in a maximum likelihood fit to extract the signal yield. The results are presented in terms of the measured signal strength modifier, mu, relative to the standard model prediction for a Higgs boson mass of 125 GeV. The observed (expected) exclusion limit at a 95% confidence level is mu < 4.2 (3.3), corresponding to a best fit value mu-hat = 1.2+1.6-1.5.
94 citations
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TL;DR: In this article, a search for the associated production of a Higgs boson with a top quark pair in the all-jet final state was presented, where events containing seven or more jets were selected from a sample of proton-proton collisions at the LHC in 2016, corresponding to an integrated luminosity of 35.9 fb−1.
Abstract: A search is presented for the associated production of a Higgs boson with a top quark pair in the all-jet final state. Events containing seven or more jets are selected from a sample of proton-proton collisions at $$ \sqrt{s}=13 $$
TeV collected with the CMS detector at the LHC in 2016, corresponding to an integrated luminosity of 35.9 fb−1. To separate the $$ \mathrm{t}\overline{\mathrm{t}}\mathrm{H} $$
signal from the irreducible $$ \mathrm{t}\overline{\mathrm{t}}+\mathrm{b}\overline{\mathrm{b}} $$
background, the analysis assigns leading order matrix element signal and background probability densities to each event. A likelihood-ratio statistic based on these probability densities is used to extract the signal. The results are provided in terms of an observed ttH signal strength relative to the standard model production cross section μ = σ/σSM, assuming a Higgs boson mass of 125 GeV. The best fit value is $$ \widehat{\mu}=0.9\pm 0.7\left(\mathrm{stat}\right)\pm 1.3\left(\mathrm{syst}\right)=0.9\pm 1.5\left(\mathrm{tot}\right) $$
, and the observed and expected upper limits are, respectively, μ < 3.8 and < 3.1 at 95% confidence levels.
94 citations
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TL;DR: Single measurements of selected cytokines using MSD platform, including IL-6, IL-8, Il-10,IL-13, TNF-α, and IFN-γ have shown to be representative of an individual’s average level over time and could be suitable for use in prospective epidemiological and clinical studies.
Abstract: There is a growing interest in the role of inflammageing for chronic disease development. Cytokines are potent soluble immune mediators that can be used as target biomarkers of inflammageing; however, their measurement in human samples has been challenging. This study aimed to assess the reliability of a pro- and anti-inflammatory cytokine panel in a sample of healthy people measured with a novel electrochemiluminescent multiplex immunoassay platform (Meso Scale Discovery, MSD), and to characterize their associations with metabolic and inflammatory phenotypes. Overall, the majority of cytokines were above the limit of detection (in at least 85.3% of the samples). Cytokines IL-6, IL-8, TNF-α, IL-10, IL-13, and IFN-γ showed overall good to fair reliability (ICC > 0.40), whereas IL-1β, IL-2, IL-4, and IL-12p70 showed poor reliability (ICC < 0.40). The reliability estimates were not substantially influenced by participants’ age, sex, obesity and C-reactive protein (CRP) levels. As expected, cytokine concentrations were elevated with advanced age most pronouncedly for IL-6, IL-8, Il-2, IFN- γ, and TNF-α. No major associations with metabolic phenotypes were observed for most cytokines, with the exception of a positive association between IL-6 and TNF-α with body mass index and CRP (ρ: 0.36; ρ: 0.20; ρ: 0.53; ρ: 0.22, respectively), and IFN-γ and IL-10 with CRP (ρ: 0.23 and ρ: 0.19, respectively). Single measurements of selected cytokines using MSD platform, including IL-6, IL-8, IL-10, IL-13, TNF-α, and IFN-γ have shown to be representative of an individual’s average level over time and could be suitable for use in prospective epidemiological and clinical studies. Such studies are highly warranted to characterize associations of cytokines with phenotypes and diseases associated with ageing.
94 citations
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Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1 +2112 more•Institutions (144)
TL;DR: In this paper, an inclusive search for supersymmetry in events with at least one b-tagged jet is performed using proton-proton collision data collected by the CMS experiment in 2012 at a center-of-mass energy of 8 TeV.
Abstract: An inclusive search for supersymmetry in events with at least one b-tagged jet is performed using proton-proton collision data collected by the CMS experiment in 2012 at a center-of-mass energy of 8 TeV. The data set size corresponds to an integrated luminosity of 19.3 fb^(−1). The two-dimensional distribution of the razor variables R^2 and M _R is studied in events with and without leptons. The data are found to be consistent with the expected background, which is modeled with an empirical function. Exclusion limits on supersymmetric particle masses at a 95% confidence level are derived in several simplified supersymmetric scenarios for several choices of the branching fractions. By combining the likelihoods of a search in events without leptons and a search that requires a single lepton (electron or muon), an improved bound on the top-squark mass is obtained. Assuming the lightest supersymmetric particle to be stable and weakly interacting, and to have a mass of 100 GeV, the branching-fraction-dependent (-independent) production of gluinos is excluded for gluino masses up to 1310 (1175) GeV. The corresponding limit for top-squark pair production is 730 (645) GeV.
93 citations
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Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam2 +2254 more•Institutions (13)
TL;DR: In this article, the authors acknowledge the support for the construction and operation of the LHC and the CMS detector provided by the following agencies: the Austrian Federal Ministry of Science, the Austrian Research and Economy and the Austrian Science Fund; the Belgian Fonds de la Recherche Scientifique, and Fonds De Wetenschappelijk Onderzoek; the Brazilian Funding
Abstract: we acknowledge the
enduring support for the construction and operation of the
LHC and the CMS detector provided by the following
funding agencies: the Austrian Federal Ministry of Science,
Research and Economy and the Austrian Science Fund; the
Belgian Fonds de la Recherche Scientifique, and Fonds
voor Wetenschappelijk Onderzoek; the Brazilian Funding
Agencies (CNPq, CAPES, FAPERJ, and FAPESP); the
Bulgarian Ministry of Education and Science; CERN; the
Chinese Academy of Sciences, Ministry of Science and
Technology, and National Natural Science Foundation of
China; the Colombian Funding Agency (COLCIENCIAS);
the Croatian Ministry of Science, Education and Sport, and
the Croatian Science Foundation; the Research Promotion
Foundation, Cyprus; the Secretariat for Higher Education,
Science, Technology, and Innovation, Ecuador; the
Ministry of Education and Research, Estonian Research
Council via Grants No. IUT23-4 and No. IUT23-6 and
European Regional Development Fund, Estonia; the
Academy of Finland, Finnish Ministry of Education and
Culture, and Helsinki Institute of Physics; the Institut
National de Physique Nucleaire et de Physique des
Particules/CNRS, and Commissariat a l’Energie
Atomique et aux Energies Alternatives/CEA, France; the
Bundesministerium fur Bildung und Forschung, Deutsche
Forschungsgemeinschaft, and Helmholtz-Gemeinschaft
Deutscher Forschungszentren, Germany; the General
Secretariat for Research and Technology, Greece; the
National Scientific Research Foundation, and National
Innovation Office, Hungary; the Department of Atomic
Energy and the Department of Science and Technology,
India; the Institute for Studies in Theoretical Physics and
Mathematics, Iran; the Science Foundation, Ireland; the
Istituto Nazionale di Fisica Nucleare, Italy; the Ministry of
Science, ICT, and Future Planning, and National Research
Foundation (NRF), Republic of Korea; the Lithuanian
Academy of Sciences; the Ministry of Education, and
University of Malaya (Malaysia); the Mexican Funding
Agencies (BUAP, CINVESTAV, CONACYT, LNS, SEP,
and UASLP-FAI); the Ministry of Business, Innovation
and Employment, New Zealand; the Pakistan Atomic
Energy Commission; the Ministry of Science and Higher
Education and the National Science Centre, Poland; the
Fundacao para a Ciencia e a Tecnologia, Portugal; JINR,
Dubna; the Ministry of Education and Science of the
Russian Federation, the Federal Agency of Atomic
Energy of the Russian Federation, Russian Academy of
Sciences, and the Russian Foundation for Basic Research;
the Ministry of Education, Science and Technological
Development of Serbia; the Secretaria de Estado de
Investigacion, Desarrollo e Innovacion and Programa
Consolider-Ingenio 2010, Spain; the Swiss Funding
Agencies (ETH Board, ETH Zurich, PSI, SNF, UniZH,
Canton Zurich, and SER); the Ministry of Science and Technology, Taipei; the Thailand Center of Excellence in
Physics, the Institute for the Promotion of Teaching
Science and Technology of Thailand, Special Task Force
for Activating Research and the National Science and
Technology Development Agency of Thailand; the
Scientific and Technical Research Council of Turkey,
and Turkish Atomic Energy Authority; the National
Academy of Sciences of Ukraine, and State Fund for
Fundamental Researches, Ukraine; the Science and
Technology Facilities Council, United Kingdom; the
U.S. Department of Energy, and the U.S. National
Science Foundation. Individuals have received support
from the Marie-Curie program and the European
Research Council and EPLANET (European Union); the
Leventis Foundation; the A. P. Sloan Foundation; the
Alexander von Humboldt Foundation; the Belgian
Federal Science Policy Office; the Fonds pour la
Formation a la Recherche dans l’Industrie et dans
l’Agriculture (FRIA-Belgium); the Agentschap voor
Innovatie door Wetenschap en Technologie (IWTBelgium);
the Ministry of Education, Youth and Sports
(MEYS) of the Czech Republic; the Council of Science
and Industrial Research, India; the HOMING PLUS program
of the Foundation for Polish Science, cofinanced by
the European Union, Regional Development Fund, the
Mobility Plus program of the Ministry of Science and
Higher Education, the National Science Center (Poland),
Contracts No. Harmonia 2014/14/M/ST2/00428, No. Opus
2013/11/B/ST2/04202, No. 2014/13/B/ST2/02543, and
No. 2014/15/B/ST2/03998, and Sonata-bis Contract
No. 2012/07/E/ST2/01406; the Thalis and Aristeia programs
cofinanced by EU-ESF and the Greek NSRF; the
National Priorities Research Program by Qatar National
Research Fund; the Programa Clarin-COFUND del
Principado de Asturias; the Rachadapisek Sompot Fund
for Postdoctoral Fellowship, Chulalongkorn University
and the Chulalongkorn Academic into its 2nd Century
Project Advancement Project (Thailand); and the Welch Foundation, Contract No. C-1845.
93 citations
Cited by
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[...]
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.
Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …
33,785 citations
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[...]
TL;DR: In this paper, a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) is presented.
Abstract: Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These
9,929 citations
01 Jan 2014
TL;DR: These standards of care are intended to provide clinicians, patients, researchers, payors, and other interested individuals with the components of diabetes care, treatment goals, and tools to evaluate the quality of care.
Abstract: XI. STRATEGIES FOR IMPROVING DIABETES CARE D iabetes is a chronic illness that requires continuing medical care and patient self-management education to prevent acute complications and to reduce the risk of long-term complications. Diabetes care is complex and requires that many issues, beyond glycemic control, be addressed. A large body of evidence exists that supports a range of interventions to improve diabetes outcomes. These standards of care are intended to provide clinicians, patients, researchers, payors, and other interested individuals with the components of diabetes care, treatment goals, and tools to evaluate the quality of care. While individual preferences, comorbidities, and other patient factors may require modification of goals, targets that are desirable for most patients with diabetes are provided. These standards are not intended to preclude more extensive evaluation and management of the patient by other specialists as needed. For more detailed information, refer to Bode (Ed.): Medical Management of Type 1 Diabetes (1), Burant (Ed): Medical Management of Type 2 Diabetes (2), and Klingensmith (Ed): Intensive Diabetes Management (3). The recommendations included are diagnostic and therapeutic actions that are known or believed to favorably affect health outcomes of patients with diabetes. A grading system (Table 1), developed by the American Diabetes Association (ADA) and modeled after existing methods, was utilized to clarify and codify the evidence that forms the basis for the recommendations. The level of evidence that supports each recommendation is listed after each recommendation using the letters A, B, C, or E.
9,618 citations
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TL;DR: In this article, a search for the Standard Model Higgs boson in proton-proton collisions with the ATLAS detector at the LHC is presented, which has a significance of 5.9 standard deviations, corresponding to a background fluctuation probability of 1.7×10−9.
9,282 citations