Andreas Schubel

TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.

TL;DR: Interestingly, receptor cross-linking caused by incubation of cells with anti-CXCR4 mAb triggers receptor trafficking, in that the receptor is rapidly internalized and recycled to the cell surface, therefore, receptor internalization and recycling may regulate the functional interaction of the receptor with envelope proteins during an initial step of HIV-1 infection.

TL;DR: It is concluded that the CCL21-induced Cl− current is a prerequisite for the chemotaxis response mediated by the activation of CXCR3 but not CCR7 receptors, indicating that in brain CCL 21 acts via a different receptor system than in lymphoid organs.

TL;DR: Analysis of gene-targeted mice identified the chemokine receptor CCR7 as an important organizer of the primary immune response, and found that lymphocytes and dendritic cells fail to migrate into the draining lymph nodes upon activation, resulting in impaired migration of lymphocytes.

TL;DR: The data show that expression of CXCR4 is tightly controlled on murine T cells and indicate that this highly conserved chemokine receptor might serve different functions in humans and mice.