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Andreas Seidler

Bio: Andreas Seidler is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 31, co-authored 142 publications receiving 4007 citations. Previous affiliations of Andreas Seidler include Finnish Institute of Occupational Health & Federal Institute for Occupational Safety and Health.


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Journal ArticleDOI
TL;DR: A role for environmental and genetic factors in the etiology of PD is supported by a case-control study investigating possible etiologic relevance to Parkinson's disease of rural factors such as farming activity, pesticide exposures, well-water drinking, and animal contacts.
Abstract: In a case-control study, we investigated the possible etiologic relevance to Parkinson9s disease (PD) of rural factors such as farming activity, pesticide exposures, well-water drinking, and animal contacts; toxicologic exposures such as wood preservatives, heavy metals, and solvents; general anesthesia; head trauma; and differences in the intrauterine environment. We recruited 380 patients in nine German clinics, 379 neighborhood control subjects, and 376 regional control subjects in the largest case-control study investigating such factors and collected data in structured personal interviews using conditional logistic regression to control for educational status and cigarette smoking. The latter was strongly inversely associated with PD. There were significantly elevated odds ratios (OR) for pesticide use, in particular, for organochlorines and alkylated phosphates, but no association was present between PD and other rural factors. A significantly elevated OR was present for exposure to wood preservatives. Subjective assessment by the probands indicated that exposure to some heavy metals, solvents, exhaust fumes, and carbon monoxide was significantly more frequent among patients than control subjects, but this was not confirmed by a parallel assessment of job histories according to a job exposure matrix. Patients had undergone general anesthesia and suffered severe head trauma more often than control subjects, but a dose-response gradient was not present. Patients reported a significantly larger number of amalgam-filled teeth before their illness than control subjects. The frequency of premature births and birth order did not differ between patients and control subjects. Patients reported significantly more relatives affected with PD than control subjects. These results support a role for environmental and genetic factors in the etiology of PD.

448 citations

Journal ArticleDOI
TL;DR: Besides individual measures to manage stress and to cope with demanding work situations, organisational changes at the workplace need to be considered to find options to reduce occupational risk factors for cardiovascular diseases.
Abstract: Purpose A systematic review was carried out to assess evidence for the association between different models of stress at work, and cardiovascular morbidity and mortality.

401 citations

Journal ArticleDOI
TL;DR: This work has shown clear evidence that cumulative work‐related UV exposure is an important risk factor for cutaneous squamous cell carcinoma occurrence and this work aims to clarify this relationship.
Abstract: Summary Background Despite the fact that ultraviolet (UV) light exposure is the most important risk factor for cutaneous squamous cell carcinoma (SCC) there is an ongoing debate concerning the relationship between cumulative work-related UV exposure and SCC occurrence. Objectives To analyse comprehensively the relationship between work-related UV exposure and SCC risk. Methods We conducted a systematic electronic literature search in PubMed (up to 5 May 2010) supplemented by a hand search, which identified 18 relevant studies that were included in the review. Data abstraction and study quality assessment was done independently by two reviewers. Maximally adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) of all included studies were pooled in a random-effects meta-analysis. Sensitivity analysis included meta-regression on study-specific covariates to explore the robustness of the results and to identify sources of heterogeneity between studies. Eighteen studies (six cohort studies, 12 case–control studies) met the eligibility criteria and were included in the systematic review. Results Sixteen studies (89%) found an increased risk of SCC in individuals with occupational UV light exposure compared with individuals without occupational UV light exposure, reaching statistical significance in 12 studies. Two studies found no association between occupational UV light exposure and SCC occurrence. The pooled OR (95% CI) was 1·77 (1·40–2·22) and did not differ significantly between cohort studies [OR (95% CI): 1·68 (1·08–2·63)] and case–control studies [OR (95% CI): 1·77 (1·37–2·30)]. Meta-regression analyses suggested an increasing strength of the association between occupational UV light exposure and SCC risk with decreasing latitude. Conclusions In summary, there is consistent epidemiological evidence for a positive association between occupational UV light exposure and SCC risk.

260 citations

Journal ArticleDOI
TL;DR: There is insufficient evidence for a link between night-shift work and breast cancer, based on the low quality of exposure data and the difference in effect by study design.
Abstract: Objective The aim of this review was to synthesize the evidence on the potential relationship between nightshift work and breast cancer. Methods We searched multiple databases for studies comparing women in shift work to those with no-shift work reporting incidence of breast cancer. We calculated incremental risk ratios (RR) per five years of night-shift work and per 300 night shift increases in exposure and combined these in a random effects dose–response meta-analysis. We assessed study quality in ten domains of bias. Results We identified 16 studies: 12 case–control and 4 cohort studies. There was a 9% risk increase per five years of night-shift work exposure in case–control studies [RR 1.09, 95% confidence interval (95% CI) 1.02–1.20; I 2 =37%, 9 studies], but not in cohort studies (RR 1.01, 95% CI 0.97–1.05; I 2 =53%, 3 studies). Heterogeneity was significant overall (I 2 =55%, 12 studies). Results for 300 night shifts were similar (RR 1.04, 95% CI 1.00–1.10; I 2 =58%, 8 studies). Sensitivity analysis using exposure transformations such as cubic splines, a fixed-effect model, or including only better quality studies did not change the results. None of the 16 studies had a low risk of bias, and 6 studies had a moderate risk. Conclusions Based on the low quality of exposure data and the difference in effect by study design, our findings indicate insufficient evidence for a link between night-shift work and breast cancer. Objective prospective exposure measurement is needed in future studies.

201 citations

Journal ArticleDOI
TL;DR: The results suggest that if antioxidants play a protective role in this disease, the amounts provided by diet alone are insufficient, and an inverse association between beta-carotene and ascorbic acid intake is found.
Abstract: In a case-control study, we compared the past dietary habits of 342 Parkinson9s disease (PD) patients recruited from nine German clinics with those of 342 controls from the same neighborhood or region. Data were gathered with a structured interview and a self-administered food-frequency questionnaire. Nutrient intakes were calculated from the reported food intakes through linkage with the German Federal Food Code and analyzed using multivariate conditional logistic regression to control for total energy intake, educational status, and cigarette smoking. At the macronutrient level, patients reported higher carbohydrate intake than controls after adjustment for total energy intake, smoking, and educational status (OR = 2.74, 95% confidence interval [CI]: 1.30-6.07, for the highest versus lowest quartile, p trend = 0.02). This was reflected in higher monosaccharide and disaccharide intakes at the nutrient level. There was no difference between patients and controls in protein and fat intake after adjustment for energy intake. We found an inverse association between the intakes of beta-carotene (OR = 0.67, 95% CI: 0.37-1.19, p trend = 0.06) and ascorbic acid (OR = 0.60, 95% CI: 0.33-1.09, p trend = 0.04) by patients, although only the trend for ascorbic acid intake reached statistical significance. There was no difference between groups for alpha-tocopherol intake after adjustment for energy intake. We also found that patients reported a significantly lower intake of niacin than controls (OR = 0.15, 95% CI: 0.07-0.33, p trend NEUROLOGY 1996;47: 644-650

195 citations


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01 Jan 2016
TL;DR: The modern applied statistics with s is universally compatible with any devices to read, and is available in the digital library an online access to it is set as public so you can download it instantly.
Abstract: Thank you very much for downloading modern applied statistics with s. As you may know, people have search hundreds times for their favorite readings like this modern applied statistics with s, but end up in harmful downloads. Rather than reading a good book with a cup of coffee in the afternoon, instead they cope with some harmful virus inside their laptop. modern applied statistics with s is available in our digital library an online access to it is set as public so you can download it instantly. Our digital library saves in multiple countries, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the modern applied statistics with s is universally compatible with any devices to read.

5,249 citations

01 Jan 2020
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Abstract: Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

4,408 citations

01 Jan 2006
TL;DR: For example, Standardi pružaju okvir koje ukazuju na ucinkovitost kvalitetnih instrumenata u onim situacijama u kojima je njihovo koristenje potkrijepljeno validacijskim podacima.
Abstract: Pedagosko i psiholosko testiranje i procjenjivanje spadaju među najvažnije doprinose znanosti o ponasanju nasem drustvu i pružaju temeljna i znacajna poboljsanja u odnosu na ranije postupke. Iako se ne može ustvrditi da su svi testovi dovoljno usavrseni niti da su sva testiranja razborita i korisna, postoji velika kolicina informacija koje ukazuju na ucinkovitost kvalitetnih instrumenata u onim situacijama u kojima je njihovo koristenje potkrijepljeno validacijskim podacima. Pravilna upotreba testova može dovesti do boljih odluka o pojedincima i programima nego sto bi to bio slucaj bez njihovog koristenja, a također i ukazati na put za siri i pravedniji pristup obrazovanju i zaposljavanju. Međutim, losa upotreba testova može dovesti do zamjetne stete nanesene ispitanicima i drugim sudionicima u procesu donosenja odluka na temelju testovnih podataka. Cilj Standarda je promoviranje kvalitetne i eticne upotrebe testova te uspostavljanje osnovice za ocjenu kvalitete postupaka testiranja. Svrha objavljivanja Standarda je uspostavljanje kriterija za evaluaciju testova, provedbe testiranja i posljedica upotrebe testova. Iako bi evaluacija prikladnosti testa ili njegove primjene trebala ovisiti prvenstveno o strucnim misljenjima, Standardi pružaju okvir koji osigurava obuhvacanje svih relevantnih pitanja. Bilo bi poželjno da svi autori, sponzori, nakladnici i korisnici profesionalnih testova usvoje Standarde te da poticu druge da ih također prihvate.

3,905 citations

Journal ArticleDOI
TL;DR: This article reviews what is known about the prevalence, incidence, risk factors, and prognosis of PD from epidemiological studies and suggests that major gene mutations cause only a small proportion of all cases.
Abstract: The causes of Parkinson's disease (PD), the second most common neurodegenerative disorder, are still largely unknown. Current thinking is that major gene mutations cause only a small proportion of all cases and that in most cases, non-genetic factors play a part, probably in interaction with susceptibility genes. Numerous epidemiological studies have been done to identify such non-genetic risk factors, but most were small and methodologically limited. Larger, well-designed prospective cohort studies have only recently reached a stage at which they have enough incident patients and person-years of follow-up to investigate possible risk factors and their interactions. In this article, we review what is known about the prevalence, incidence, risk factors, and prognosis of PD from epidemiological studies.

3,474 citations