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Andreas Sturzenegger
Researcher at University of Zurich
Publications - 5
Citations - 395
Andreas Sturzenegger is an academic researcher from University of Zurich. The author has contributed to research in topics: DNA repair & Replication protein A. The author has an hindex of 5, co-authored 5 publications receiving 338 citations. Previous affiliations of Andreas Sturzenegger include Academy of Sciences of the Czech Republic.
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Journal ArticleDOI
DNA2 Cooperates with the WRN and BLM RecQ Helicases to Mediate Long-range DNA End Resection in Human Cells
Andreas Sturzenegger,Kamila Burdova,Radhakrishnan Kanagaraj,Maryna Levikova,Cosimo Pinto,Petr Cejka,Pavel Janscak,Pavel Janscak +7 more
TL;DR: Evidence is presented that WRN and BLM act epistatically with DNA2 to promote the long-range resection of double strand break ends in human cells and new mechanistic insights are provided into the process of DNA end resection in mammalian cells.
Journal ArticleDOI
Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures.
Sujoy Chatterjee,Jennifer Zagelbaum,Pavel Savitsky,Andreas Sturzenegger,Diana Huttner,Pavel Janscak,Ian D. Hickson,Opher Gileadi,Eli Rothenberg +8 more
TL;DR: It is shown that the activity of BLM is substrate dependent, and highly regulated by a short ssDNA segment that separates the G4 motif from dsDNA, and a model is presented that proposes a unique role for G4 structures in modulating theActivity of DNA processing enzymes.
Journal ArticleDOI
The MMS22L–TONSL heterodimer directly promotes RAD51‐dependent recombination upon replication stress
Wojciech Piwko,Lucie J Mlejnkova,Karun Mutreja,Lepakshi Ranjha,Diana Stafa,Alexander Smirnov,Mia M. L. Brodersen,Ralph Zellweger,Andreas Sturzenegger,Pavel Janscak,Massimo Lopes,Matthias Peter,Petr Cejka +12 more
TL;DR: By specifically regulating RAD51 activity at uncoupled replication forks, MMS22L–TONSL stabilizes perturbed replication forks by promoting replication fork reversal and stimulating their HR‐mediated restart in vivo.
Journal ArticleDOI
Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing
TL;DR: It is suggested that RECQ5 acts during the post-synaptic phase of synthesis-dependent strand annealing to prevent formation of aberrant RAD51 filaments on the extended invading strand, thus limiting its channeling into potentially hazardous crossover pathway of HR.
Journal ArticleDOI
The Mismatch-Binding Factor MutSβ Can Mediate ATR Activation in Response to DNA Double-Strand Breaks
Kamila Burdova,Boris Mihaljevic,Andreas Sturzenegger,Nagaraja Chappidi,Pavel Janscak,Pavel Janscak +5 more
TL;DR: It is suggested that hairpin loops might form in ssDNA generated at sites of DNA damage and trigger ATR activation in a process mediated by MutSβ.